Abstract: Disclosed are methods and systems for the isolation and detection of microbes from a sample. The use of binding agents for isolation of a microbe of interest from a sample are described. In certain embodiments, the methods use ribosome-based and/or bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. For example, embodiments of the present invention can achieve total amplification of at least 10,000 from a single infected cell.

Abstract: Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.

Abstract: Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.

Abstract: Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.

Abstract: Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.

Abstract: Disclosed herein are methods and systems for the detection of an analyte of interest by an amplified assay. The method and systems of the invention utilize the high specificity of biomolecules that have been coupled to a solid support to further amplify a signal produced by the interaction of a binding agent with the analyte of interest as a means to detect low levels of the analyte of interest present in a sample. In certain embodiments, for immunochemical (for example, ELISA or RIA) or immunofluorescence assays in which a protein to be identified is bound directly or through capture antibodies to a passivated surface, amplification of ˜10,000-fold can be achieved.

Abstract: Disclosed are methods and systems for the isolation and detection of microbes from a sample. The use of binding agents for isolation of a microbe of interest from a sample are described. In certain embodiments, the methods use ribosome-based and/or bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. For example, embodiments of the present invention can achieve total amplification of at least 10,000 from a single infected cell.

Abstract: Disclosed are methods and systems for the isolation and detection of microbes from a sample. The use of binding agents for isolation of a microbe of interest from a sample are described. In certain embodiments, the methods use ribosome-based and/or bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. For example, embodiments of the present invention can achieve total amplification of at least 10,000 from a single infected cell.

Abstract: Disclosed are methods, devices and systems for the isolation and detection of biomolecules from a sample. The embodiments, detection of such biomolecules provides for detection of microorganisms. For example, disclosed are methods, devices and systems that use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms. The devices, systems and methods of the invention may allow for the detection of certain biomolecules peptides and ions in real time using minute amounts of sample.

Abstract: There is alteration of a late-bound expression produced by a compiler into an early-bound structure. Alteration of the late-bound expression can occur at runtime and a visitor pattern can be used to create the alteration. In one instance, a conversion from late-bound to early-bound takes place through replacing a late-bound property with a statically typed call. The early-bound structure can translate into an expression tree to enable an implementation of a store specific query operated upon storage.

Abstract: A method is provided for identifying viral positive biological fluid donations in the fewest number of test cycles. The method comprises providing biological fluid donations and defining an n-dimensional matrix comprising a multiplicity of elements, each element being identified by a matrix notation comprising an index for each dimension of the array. Samples are taken from each fluid donation and mapped to a matrix element with each sample identified by its corresponding element's notation; n aliquots being taken from each sample and subpools formed from the aliquots with each subpool containing an aliquot from all samples mapped to elements in which one of the dimensional indices is fixed. Subpools are tested for viral indication and the dimensional index of each subpool that returns a positive viral indication is determined. The dimensional indices are combined to identify a subset of matrix elements that contain a viral positive sample.

Abstract: Programmers typically like operating with databases through use of classes. Classes allow a user to function with a database through use of a non-database programming language. To ease use of the classes, a class context is generated at runtime that does not force a programmer to handle various source files that are a product of class generation. Therefore, the user can have the ease of using classes without having to perform extra actions.

Abstract: A data mapping architecture for mapping between two or more data sources without modifying the metadata or structure of the data sources themselves. Data mapping also supports updates. The architecture also supports at least the case where data sources that are being mapped, are given, their schemas predefined, and cannot be changed. The architecture includes a mapping component that receives respective metadata from at least two arbitrary data models, and maps expressions between the data models.

Abstract: The present invention relates to a system and methodology to facilitated data object persistence. An object schema is utilized to provide metadata for types in addition to what is provided by the type system for an underlying programming language. This metadata is then utilized by the system to translate data to and from user objects during a materialization or persistence process. The object schema provides information external to programming logic and type definitions. Consequently, the object schema can be deployed independent of an application thereby allowing the persistence storage of user objects to change without force the user to recompile and deploy application code.

Abstract: The claimed subject matter relates to an architecture that can facilitate an incremental approach to an Object-Relational mapping solution. The architecture can provide a rich data model that is defined at the value layer. The rich data model can expose an interface that conforms with the interfaces exposed by common storage-specific data providers. The architecture can extend common storage-specific data provider to support common command representations, and provide entity services that work in terms of the rich data model as well as object services such as identity management, updating and change tracking.

Abstract: Systems, processes, and devices are provided which are useful for testing blood or plasma donations to detect those specific donations which are contaminated by a virus above a predetermined level. Samples are formed into pools which are subsequently tested for virus contamination by a high-sensitivity test such as PCR. The pools are tested in accordance with an algorithm by which a sample from each donation is mapped to each element of an N-dimensional matrix or grid. Each element of the matrix is identified by a matrix identifier, Xrcs, where rcs defines the dimensional index. An aliquot is taken from each sample, and subpools are formed, each subpool comprising aliquots of samples in which one dimensional index is fixed. All of the subpools are tested in one PCR test cycle.

Abstract: There is alteration of a late-bound expression produced by a compiler into an early-bound structure. Alteration of the late-bound expression can occur at runtime and a visitor pattern can be used to create the alteration. In one instance, a conversion from late-bound to early-bound takes place through replacing a late-bound property with a statically typed call. The early-bound structure can translate into an expression tree to enable an implementation of a store specific query operated upon storage.

Abstract: Programmers typically like operating with databases through use of classes. Classes allow a user to function with a database through use of a non-database programming language. To ease use of the classes, a class context is generated at runtime that does not force a programmer to handle various source files that are a product of class generation. Therefore, the user can have the ease of using classes without having to perform extra actions.

Abstract: Binding can automatically take place between controls and information sources at runtime. This minimizes an amount of code that is to be generated by a user and thus can lower errors from the code. In addition, some wizards that allow binding without code writing can become problematic since some information is not available at runtime (e.g., when the wizard operates prior to runtime.) Relevant information is received and at least one binding is created based off received information.

Abstract: Lightweight query processing for in-memory or cache memory data structures, such as DataSet, is provided. Prior to executing a query over an in-memory data structure, a query processor determines whether any benefits can be obtained by first optimizing the query execution strategy. Additionally, one or more bail out points can be applied to the optimization analysis to further enhance query execution speed for circumstances where optimization is unlikely to provide significant performance benefits. The lightweight query processing techniques can be supported in any framework for processing or formulating queries of in-memory data structures, such as language integrated query (LINQ) queries.