Patents by Inventor Andrew J. Flint

Andrew J. Flint has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay for protein tyrosine phosphatases
    Publication number: 20020009762
    Abstract: The invention relates in part to screening assays for identifying agents that alter the interaction between a protein tyrosine phosphatase (PTP) and its tyrosine phosphorylated polypeptide substrate, using fluorescence energy signals generated by detectably labeled substrates. Assays are provided in certain embodiments, including high throughput screening assays, wherein candidate agents are screened by fluorescence polarization for their ability to influence (i) binding of substrate trapping mutant PTPs to substrates, or (ii) dephosphorylation of tyrosine phosphorylated substrates by PTPs.
    Type: Application
    Filed: February 13, 2001
    Publication date: January 24, 2002
    Inventors: Andrew J. Flint, Deborah E. Cool
  • Substrate trapping protein tyrosine phosphatases
    Patent number: 5951979
    Abstract: Novel protein tyrosine phosphatases in which the invariant aspartate residue is replaced with an alanine residue and which bind to a tyrosine phosphorylated substrate and are catalytically attenuated are described. Also described are methods of identifying tyrosine phosphorylated proteins which complex with the described protein tyrosine phosphatases.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: September 14, 1999
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Nicholas Tonks, Andrew J. Flint
  • Substrate trapping protein tyrosine phosphatases
    Patent number: 5912138
    Abstract: Novel protein tyrosine phosphatases in which the invariant aspartate residue is replaced with an alanine residue and which bind to a tyrosine phosphorylated substrate and are catalytically attenuated are described. Also described are methods of identifying tyrosine phosphorylated proteins which complex with the described protein tyrosine phosphatases.
    Type: Grant
    Filed: July 25, 1996
    Date of Patent: June 15, 1999
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Nicholas Tonks, Andrew J. Flint