Patents by Inventor Andrew J. Hirsh

Andrew J. Hirsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazinoylguanidine compounds for use as taste modulators
    Patent number: 8288391
    Abstract: The present invention relates to blocking salt taste using compounds of Formula I as defined herein.
    Type: Grant
    Filed: April 3, 2008
    Date of Patent: October 16, 2012
    Assignee: Parion Sciences, Inc.
    Inventors: Michael R. Johnson, Richard C. Boucher, Andrew J. Hirsh
  • Phenyl substituted pyrazinoylguanidine sodium channel blockers possessing beta agonist activity
    Patent number: 8163758
    Abstract: Provided is class of sodium channel blockers. One example of such a compound is shown by the following formula: The compounds are useful for promoting hydration of mucosal surfaces and treating a variety of disease conditions.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: April 24, 2012
    Assignee: Parion Sciences, Inc.
    Inventors: Michael Ross Johnson, Andrew J. Hirsh, Richard C. Boucher, Jianzhong Zhang
  • Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
    Patent number: 8058278
    Abstract: The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: November 15, 2011
    Assignee: Parion Sciences, Inc.
    Inventors: Michael Ross Johnson, Richard C. Boucher, Andrew J. Hirsh
  • Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
    Patent number: 7981898
    Abstract: The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: July 19, 2011
    Assignee: Parion Sciences, Inc.
    Inventors: Michael Ross Johnson, Richard C. Boucher, Andrew J. Hirsh
  • PHENYL SUBSTITUTED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS POSSESSING BETA AGONIST ACTIVITY
    Publication number: 20110008268
    Abstract: The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
    Type: Application
    Filed: June 11, 2007
    Publication date: January 13, 2011
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael Ross Johnson, Andrew J. Hirsh, Richard C. Boucher, Jianzhong Zhang
  • METHODS OF ENHANCING MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES
    Publication number: 20090082287
    Abstract: The present invention relates to methods and compositions for treating diseases ameliorated by increased mucociliary clearance and mucosal hydration by administering an effective amount of a sodium channel blocker as defined herein and an osmolyte to a subject to a subject in need of increased mucociliary clearance and mucosal hydration.
    Type: Application
    Filed: September 7, 2007
    Publication date: March 26, 2009
    Applicant: PARION SCIENCES, INC.
    Inventors: Michael Ross Johnson, Richard C. Boucher, Andrew J. Hirsh
  • METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS
    Publication number: 20080293740
    Abstract: The present invention provides a variety of methods of treatment of acid-sensing ion channel (ASIC) mediated pain, cough, and central nervous system disorders by ASICs inhibition with a series of pyrazinoylguanidine compounds represented by formula (I) as defined herein.
    Type: Application
    Filed: April 3, 2008
    Publication date: November 27, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Richard C. BOUCHER, Andrew J. HIRSH
  • PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS
    Publication number: 20080249109
    Abstract: The present invention relates to blocking salt taste using compounds of Formula I as defined herein.
    Type: Application
    Filed: April 3, 2008
    Publication date: October 9, 2008
    Applicant: PARION SCIENCES, Inc.
    Inventors: Michael R. JOHNSON, Richard C. Boucher, Andrew J. Hirsh