Abstract: This disclosure provides prosthetic arteriovenous grafts having a blood-contacting layer; an intermediate layer; and a tissue-interface layer formed of a microporous biomaterial with a textured microporous surface, the prosthetic arteriovenous grafts providing vascular access for hemodialysis and being capable of reducing perigraft fibrotic capsular formation, and a method of maintaining the patency of the prosthetic arteriovenous grafts.

Abstract: This disclosure provides a method for reducing or preventing the formation and/or accumulation of drusen in an eye of a mammalian subject in need thereof, the method comprising implanting one or more microporous devices into the eye, each device having a device body and an outer surface, wherein the microporous device is formed of a biocompatible elastomeric material and comprises a plurality of interconnected pores throughout the device body.

Abstract: Provided herein are implantable devices, such as vascular grafts and access port for hemodialysis, that include a microporous sheath layer having a corrugated outer surface, and use therefore for reducing the risk of infection or stenosis.

Abstract: Provided herein are implantable devices, such as vascular grafts and access port for hemodialysis, that include a microporous sheath layer having a corrugated outer surface, and use therefore for reducing the risk of infection or stenosis.

Abstract: This disclosure provides vascular grafts having a textured microporous surface capable of reducing perigraft fibrotic capsular formation, and a method of maintaining the patency of the vascular grafts.

Abstract: Provided herein are implantable devices, such as vascular grafts and access port for hemodialysis, that include a microporous sheath layer having a corrugated outer surface, and use therefore for reducing the risk of infection or stenosis.

Abstract: One embodiment provides an apparatus. The apparatus includes a substrate body that includes a top end, an opposing bottom end and a curved outer surface positioned there between, and a clear sight bore aperture centered at a longitudinal axis of the substrate body. The apparatus further includes a trunk line aperture defined in the outer surface of the substrate body. The trunk line aperture has a first end positioned at a top end of the substrate body, off-center from the longitudinal axis. The first end of the trunk line aperture is configured to couple to a detonator. The apparatus further includes a plurality of helical track apertures defined in the outer surface of the substrate body. A respective first end of each helical track aperture is coupled to the trunk line aperture. The apparatus further includes a plurality of termination apertures defined in the outer surface of the substrate body adjacent the bottom end of the substrate body.

Abstract: One embodiment provides an apparatus. The apparatus includes a substrate body that includes a top end, an opposing bottom end and a curved outer surface positioned there between, and a clear sight bore aperture centered at a longitudinal axis of the substrate body. The apparatus further includes a trunk line aperture defined in the outer surface of the substrate body. The trunk line aperture has a first end positioned at a top end of the substrate body, off-center from the longitudinal axis. The first end of the trunk line aperture is configured to couple to a detonator. The apparatus further includes a plurality of helical track apertures defined in the outer surface of the substrate body. A respective first end of each helical track aperture is coupled to the trunk line aperture. The apparatus further includes a plurality of termination apertures defined in the outer surface of the substrate body adjacent the bottom end of the substrate body.

Abstract: Provided herein are implantable devices, such as vascular grafts and access port for hemodialysis, that include a microporous sheath layer having a corrugated outer surface, and use therefore for reducing the risk of infection or stenosis.

Abstract: This disclosure provides a method for reducing or preventing the formation and/or accumulation of drusen in an eye of a mammalian subject in need thereof, the method comprising implanting one or more microporous devices into the eye, each device having a device body and an outer surface, wherein the microporous device is formed of a biocompatible elastomeric material and comprises a plurality of interconnected pores throughout the device body.

Abstract: This disclosure provides vascular grafts having a textured microporous surface capable of reducing perigraft fibrotic capsular formation, and a method of maintaining the patency of the vascular grafts.

Abstract: Described herein is a device for glaucoma treatment and monitoring that comprises a combination of an intraocular pressure (IOP) sensor and a glaucoma drainage device. The device comprises an IOP sensor and an inductive antenna mounted within a porous biocompatible material that forms the drainage path. The IOP sensor is mounted in a footplate portion of the device and is mountable in the anterior chamber of an eye. The footplate portion is connected to a body portion that houses the spiral antenna by a neck portion which retains the footplate portion in a suitable position within the anterior chamber. Due to its size, the footplate portion housing the IOP sensor can readily be inserted into the anterior chamber with the body portion housing the spiral antenna located outside of the anterior chamber in a sub-scleral space to disperse the aqueous humour.

Abstract: This disclosure provides implantable devices coated with microporous surface layers with macrotopographic features that improve bio-integration at the interface of the implantable devices and the surrounding tissue.

Abstract: This disclosure provides implantable devices coated with microporous surface layers with macrotopographic features that improve bio-integration at the interface of the implantable devices and the surrounding tissue.

Abstract: This disclosure provides implantable devices coated with microporous surface layers with macrotopographic features that improve bio-integration at the interface of the implantable devices and the surrounding tissue.

Abstract: Described herein is a device for glaucoma treatment and monitoring that comprises a combination of an intraocular pressure (IOP) sensor and a glaucoma drainage device. The device comprises an IOP sensor and an inductive antenna mounted within a porous biocompatible material that forms the drainage path. The IOP sensor is mounted in a footplate portion of the device and is mountable in the anterior chamber of an eye. The footplate portion is connected to a body portion that houses the spiral antenna by a neck portion which retains the footplate portion in a suitable position within the anterior chamber. Due to its size, the footplate portion housing the IOP sensor can readily be inserted into the anterior chamber with the body portion housing the spiral antenna located outside of the anterior chamber in a sub-scleral space to disperse the aqueous humour.

Abstract: This disclosure provides implantable devices coated with microporous surface layers with macrotopographic features that improve bio-integration at the interface of the implantable devices and the surrounding tissue.