Abstract: The present disclosure relates to compositions and methods for reducing the concentration of extendable free and buried primers relative to amplification product in a sample. The disclosed methods and compositions can be used to reduce or eliminate index hopping in a next generation sequencing (NGS) platform.

Abstract: An integrated mobile phone protective case and carrier drawer system for securely containing small personal items, comprising: a regular mobile phone protective case portion; a drawer space integrally contained inside a rear part of the integrated mobile phone protective case; a drawer cover separate from the integrated mobile phone protective case, configured to mate onto the rear part of the integrated mobile phone protective case; a latching extension integrally affixed with the drawer cover; a latch integrally affixed with the integrated mobile phone protective case and configured to latch together with the latching extension; and a release actuator for releasing the latching extension from the latch; wherein: after the drawer cover has been slid onto the integrated mobile phone protective case, the latching extension simultaneously becomes latched together with the latch thereby preventing any personal items contained within the personal item carriage drawer from being removed from the drawer.

Abstract: An integrated mobile phone protective case and carrier drawer system for securely containing small personal items, comprising: a regular mobile phone protective case portion; a drawer space integrally contained inside a rear part of the integrated mobile phone protective case; a drawer cover separate from the integrated mobile phone protective case, configured to mate onto the rear part of the integrated mobile phone protective case; a latching extension integrally affixed with the drawer cover; a latch integrally affixed with the integrated mobile phone protective case and configured to latch together with the latching extension; and a release actuator for releasing the latching extension from the latch; wherein: after the drawer cover has been slid onto the integrated mobile phone protective case, the latching extension simultaneously becomes latched together with the latch thereby preventing any personal items contained within the personal item carriage drawer from being removed from the drawer.

Abstract: An “active learning” method trains a compact classifier for view-based object recognition. The method actively generates its own training data. Specifically, the generation of synthetic training images is controlled within an iterative training process. Valuable and/or informative object views are found in a low-dimensional rendering space and then added iteratively to the training set. In each iteration, new views are generated. A sparse training set is iteratively generated by searching for local minima of a classifier's output in a low-dimensional space of rendering parameters. An initial training set is generated. The classifier is trained using the training set. Local minima are found of the classifier's output in the low-dimensional rendering space. Images are rendered at the local minima. The newly-rendered images are added to the training set. The procedure is repeated so that the classifier is retrained using the modified training set.

Abstract: A teaching and learning system includes a data store and a server computing device. The server computing device is programmed to retrieve digital data from the data store and to generate and transfer digital data across a network to user computing devices associated with users. The digital data is configured to be interpreted by the user computing devices to display to the users an interactive web site, the web site including a plurality of learning packets. Each learning packet includes a title and multiple content sections. The title includes a text description of a topic associated with an academic topic. The multiple content sections include at least one content window, where each content window includes content having a content type selected by the author of the learning packet from a plurality of different available content types. The content of each content section includes information to teach the user about the topic identified in the title.

Abstract: An “active learning” method trains a compact classifier for view-based object recognition. The method actively generates its own training data. Specifically, the generation of synthetic training images is controlled within an iterative training process. Valuable and/or informative object views are found in a low-dimensional rendering space and then added iteratively to the training set. In each iteration, new views are generated. A sparse training set is iteratively generated by searching for local minima of a classifier's output in a low-dimensional space of rendering parameters. An initial training set is generated. The classifier is trained using the training set. Local minima are found of the classifier's output in the low-dimensional rendering space. Images are rendered at the local minima. The newly-rendered images are added to the training set. The procedure is repeated so that the classifier is retrained using the modified training set.

Abstract: The present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.

Abstract: Briefly, the present invention provides a system and method for high throughput processing using sample holders. The system has a plurality of work perimeters, with a rotational robot preferably associated with each work perimeter. At least one transfer station area is provided between adjacent work perimeters to facilitate robotic transfer of sample holders from one work perimeter to another area. Each work perimeter typically includes a plurality of defined station locations, with each station location positioned to be accessible by the robot associated with that area. In addition, each station location is typically configured to receive a device, such as an automated instrument or a holding nest. Device components are arranged at selected station locations according to specific application requirements to provide a flexible, robust, reliable, and accurate high throughput processing system.

Abstract: An operating system independent computer language to enable non-technical users to manipulate data from within large pre-existing files or databases with limited involvement of programmers. This language can also be used to distribute the processing for such file manipulations across any group of networked computers.

Abstract: A fermentation apparatus is constructed to produce a known and repeatable amount of untainted fermentation product using multiple fermentation vessels. To facilitate further processing compatible with other product processing steps, the fermentation apparatus has an array of sample vessels arranged in a container frame. The container frame is configured to hold the sample vessels during fermentation and to transport the vessel array to or from another processing station. Corresponding to the number of sample vessels in the sample vessel array, a cannula array is configured such that each cannula may be placed inside a sample vessel. The cannula array is attached to a gas distributor that delivers oxygen and/or one or more other gases from a gas source through the cannula into the sample vessel. Because the fermentation volume for each individual sample vessel is smaller than a bulk fermentation apparatus, the fermentation product yields are predictable and cell growth rates can be effectively optimized.

Abstract: A fermentation apparatus is constructed to produce a known and repeatable amount of untainted fermentation product using multiple fermentation vessels. To facilitate further processing compatible with other product processing steps, the fermentation apparatus has an array of sample vessels arranged in a container frame. The container frame is configured to hold the sample vessels during fermentation and to transport the vessel array to or from another processing station. Corresponding to the number of sample vessels in the sample vessel array, a cannula array is configured such that each cannula may be placed inside a sample vessel. The cannula array is attached to a gas distributor that delivers oxygen and/or one or more other gases from a gas source through the cannula into the sample vessel. Because the fermentation volume for each individual sample vessel is smaller than a bulk fermentation apparatus, the fermentation product yields are predictable and cell growth rates can be effectively optimized.

Abstract: A radiation sensor which includes a thermopile for detecting radiant energy. The thermopile and a support rim for the thermopile are fabricated as an integrated unit to form a support chip. The support chip is mated to a mating chip so that the thermopile is positioned in an inner cavity region of the radiation sensor. The sensor has a window which permits the transmission of radiant energy into the enclosure such that the radiant energy impinges upon a central absorber region of the thermopile.

Abstract: A fermentation apparatus is constructed to produce a known and repeatable amount of unpoisoned fermentation product using multiple fermentation vessels. To facilitate further processing compatible with other product processing steps, the fermentation apparatus has an array of sample vessels arranged in a container frame. The container frame is configured to hold the sample vessels during fermentation and to transport the vessel array to or from another processing station. Corresponding to the number of sample vessels in the sample vessel array, a cannula array is configured such that each cannula may be placed inside a sample vessel. The cannula array is attached to a gas distributor that delivers oxygen and/or one or more other gases from a gas source through the cannula into the sample vessel.

Abstract: A fermentation apparatus is constructed to produce a known and repeatable amount of unpoisoned fermentation product using multiple fermentation vessels. To facilitate further processing compatible with other product processing steps, the fermentation apparatus has an array of sample vessels arranged in a container frame. The container frame is configured to hold the sample vessels during fermentation and to transport the vessel array to or from another processing station. Corresponding to the number of sample vessels in the sample vessel array, a cannula array is configured such that each cannula may be placed inside a sample vessel. The cannula array is attached to a gas distributor that delivers oxygen and/or one or more other gases from a gas source through the cannula into the sample vessel.

Abstract: The specimen plate lid is generally a block, with a cover portion and a side portion. An alignment protrusion extends from the side portion and cooperates with an alignment member of the specimen plate to assist in manually or roboticly guiding the lid onto the specimen plate. An underside surface of the cover has a sealing perimeter for receiving a seal constructed from a compliant material, and shaped to cooperate with a complimentary sealing surface on the specimen plate. The lid is weighted so that when the lid is aligned and positioned on the specimen plate, the weight of the lid provides a gravitational force to sufficiently compress the seal against the sealing surface on the specimen plate. Accordingly, the lid is sufficiently sealed to the specimen plate to avoid contamination and impermissible drying.

Abstract: An automated centrifuge comprising a rotor having a plurality of cavities located in the rotor. A tube is structured to be insertable into any one of the cavities and a controller is configured to insert the tube into the cavity. The cavities located in the rotor are grouped in clusters, and the cavities of each cluster are substantially parallel.

Abstract: The specimen plate lid is generally a block, with a cover portion and a side portion. An alignment protrusion extends from the side portion and cooperates with an alignment member of the specimen plate to assist in manually or roboticly guiding the lid onto the specimen plate. An underside surface of the cover has a sealing perimeter for receiving a seal constructed from a compliant material, and shaped to cooperate with a complimentary sealing surface on the specimen plate. The lid is weighted so that when the lid is aligned and positioned on the specimen plate, the weight of the lid provides a gravitational force to sufficiently compress the seal against the sealing surface on the specimen plate. Accordingly, the lid is sufficiently sealed to the specimen plate to avoid contamination and impermissible drying.

Abstract: A fermentation apparatus is constructed to produce a known and repeatable amount of untainted fermentation product using multiple fermentation vessels. To facilitate further processing compatible with other product processing steps, the fermentation apparatus has an array of sample vessels arranged in a container frame. The container frame is configured to hold the sample vessels during fermentation and to transport the vessel array to or from another processing station. Corresponding to the number of sample vessels in the sample vessel array, a cannula array is configured such that each cannula may be placed inside a sample vessel. The cannula array is attached to a gas distributor that delivers oxygen and/or one or more other gases from a gas source through the cannula into the sample vessel. Because the fermentation volume for each individual sample vessel is smaller than a bulk fermentation apparatus, the fermentation product yields are predictable and cell growth rates can be effectively optimized.

Abstract: A radiation sensor which includes a thermopile for detecting radiant energy. The thermopile and a support rim for the thermopile are fabricated as an integrated unit to form a support chip. The support chip is mated to a mating chip so that the thermopile is positioned in an inner cavity region of the radiation sensor. The sensor has a window which permits the transmission of radiant energy into the enclosure such that the radiant energy impinges upon a central absorber region of the thermopile.

Abstract: An automated centrifuge comprising a rotor having a plurality of sample receiving elements located in the rotor is provided. Sample processing components are structured to be insertable into any one of the receiving elements and a controller is configured to insert the sample processing components into the sample receiving elements. The sample receiving elements located in the rotor are grouped in clusters, and the cavities of each cluster are substantially parallel. Also, an automated centrifuge system comprising a rotor including a plurality of clusters of receiving elements, each element including a longitudinal axis, with the longitudinal axes of each element in a cluster being substantially parallel is provided. A plurality of sample processing components are arranged in groups, with each group configured to be received into adjacent clusters. A rotor position member is structured to determine the position of each cluster.