Patents by Inventor Andrew J. Modzelewski

Andrew J. Modzelewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Simultaneous detection of protein isoforms and nucleic acids from low starting cell numbers
    Publication number: 20210278367
    Abstract: Dual nucleic acid and protein isoform measurements are performed on low starting cell numbers (e.g. equivalent to the number of blastomeres composing early embryonic development stages (morula and blastocysts)), comprising integrating fractionation polyacrylamide gel electrophoresis (fPAGE) of 10-100 cells with off-chip analysis of nucleic acids in the nuclei.
    Type: Application
    Filed: May 24, 2021
    Publication date: September 9, 2021
    Applicant: The Regents of the University of California
    Inventors: Amy E. Herr, Lin He, Andrew J. Modzelewski, Elisabet Rosàs-Canyelles
  • METHODS FOR GENOME EDITING IN ZYGOTES
    Publication number: 20190093128
    Abstract: The present disclosure provides methods of modifying the genome of a mammalian zygote. The present disclosure provides methods of modulating transcription in a mammalian zygote. The present disclosure provides methods of labeling a target nucleic acid in the genome of a mammalian zygote. The present disclosure provides methods of delivering a ribonucleoprotein complex into a mammalian zygote. The present disclosure provides methods of delivering a polypeptide or a nucleic acid into a mammalian zygote.
    Type: Application
    Filed: March 30, 2017
    Publication date: March 28, 2019
    Inventors: Sean Chen, Andrew J. Modzelewski, Lin He, Angus Lee