Abstract: A calibration monitoring system is provided to automatically monitor the calibration status of tools and other inventory items, such as upon the items being issued from or returned to the automated calibration monitoring system. The system identifies an inventory item, for example a calibrated torque wrench or other calibrated tool identified based on a unique identifying tag attached thereto. The system retrieves a calibration parameter value for the item from a calibration database, and completes a calibration measurement of the item based on the calibration parameter value. In the example, a torque measurement of the calibrated torque wrench can thus be automatically completed. In turn, the system determines a current calibration status of the item based on the calibration measurement, and selectively enables or disables issuance of the inventory item from the system according to the item's status as being in calibration or out of calibration.

Abstract: This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: The present application describes an automated inventory control system that comprises a storage device, a sensing system, a data storage, and one or more processors. The storage device includes a plurality of storage locations for storing objects. The sensing system is configured to associate the storage device with a first location and with a second location. The data storage is configured to store configurable data of the storage device. The one or more processors are configured to send configurable data corresponding to the first location to the storage device in response to receiving information associating the storage device with the first location from the sensing system. In response to receiving information associating the storage device with the second location from the sensing system, the one or more processors are configured to send configurable data corresponding to the second location to the storage device.

Abstract: Methods and controllers for controlling engine speed to reduce NVH that occurs in conjunction with transmission shifts are described. In some embodiments, when a transmission shift to a target gear is expected, a target engine speed appropriate for the target gear is first determined. A target rate of change of the engine speed is calculated from the initial engine speed and target engine speed in conjunction with a target transition time. A target torque is then calculated from the target rate of change of engine speed. A target firing fraction or induction ratio are determined that are desired for use with the target engine speed based on the target torque. The transition to the target engine speed and target firing fraction or induction ratio are completed before the gear shift is completed. The described approaches are well suited for use during skip fire or other cylinder output level modulation operation of the engine.

Abstract: A calibration monitoring system is provided to automatically monitor the calibration status of tools and other inventory items, such as upon the items being issued from or returned to the automated calibration monitoring system. The system identifies an inventory item, for example a calibrated torque wrench or other calibrated tool identified based on a unique identifying tag attached thereto. The system retrieves a calibration parameter value for the item from a calibration database, and completes a calibration measurement of the item based on the calibration parameter value. In the example, a torque measurement of the calibrated torque wrench can thus be automatically completed. In turn, the system determines a current calibration status of the item based on the calibration measurement, and selectively enables or disables issuance of the inventory item from the system according to the item's status as being in calibration or out of calibration.

Abstract: Methods and controllers for controlling engine speed to reduce NVH that occurs in conjunction with transmission shifts are described. In some embodiments, when a transmission shift to a target gear is expected, a target engine speed appropriate for the target gear is first determined. A target rate of change of the engine speed is calculated from the initial engine speed and target engine speed in conjunction with a target transition time. A target torque is then calculated from the target rate of change of engine speed. A target firing fraction or induction ratio are determined that are desired for use with the target engine speed based on the target torque. The transition to the target engine speed and target firing fraction or induction ratio are completed before the gear shift is completed. The described approaches are well suited for use during skip fire or other cylinder output level modulation operation of the engine.

Abstract: New treatments for Ikaros and/or Aiolos mediated disorders are provided that comprise administering an effective amount of a cereblon binder that degrades Ikaros or Aiolos by the ubiquitin proteasome pathway.

Abstract: The present application describes an automated inventory control system that comprises a storage device, a sensing system, a data storage, and one or more processors. The storage device includes a plurality of storage locations for storing objects. The sensing system is configured to associate the storage device with a first location and with a second location. The data storage is configured to store configurable data of the storage device. The one or more processors are configured to send configurable data corresponding to the first location to the storage device in response to receiving information associating the storage device with the first location from the sensing system. In response to receiving information associating the storage device with the second location from the sensing system, the one or more processors are configured to send configurable data corresponding to the second location to the storage device.

Abstract: This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

Abstract: Pharmaceutical Degraders and Degrons for use in therapeutic applications are described herein.

Abstract: This invention provides pharmaceutical protein degraders and E3 ubiquitin ligase binders for therapeutic applications as described further herein.

Abstract: This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides Degronimers that have carbon-linked E3 Ubiquitin Ligase targeting moieties (Degrons), which can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: This invention provides Degronimers that have E3 Ubiquitin Ligase targeting moieties (Degrons) that can be linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation. The invention also provides Degrons that can be used to treat disorders mediated by cereblon or an Ikaros family protein, and methods of use and compositions thereof as well as methods for their preparation.

Abstract: Pharmaceutical Degraders and Degrons for use in therapeutic applications are described herein.

Abstract: The present invention provides a means to modulate gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knock-out or knock-in strategies and strategies that provide for correction, or alteration, of single nucleotides. The invention includes inserting into the genome a nucleotide encoding a heterobifunctional compound targeting protein (dTAG) in-frame with the nucleotide sequence of a gene encoding an endogenously expressed protein of interest which, upon expression, produces an endogenous protein-dTAG hybrid protein. This allows for targeted protein degradation of the dTAG and the fused endogenous protein using a heterobifunctional compound.

Abstract: This invention is in the area of compositions and methods for regulating chimeric antigen receptor immune effector cell, for example T-cell (CAR-T), therapy to modulate associated adverse inflammatory responses, for example, cytokine release syndrome and tumor lysis syndrome, using targeted protein degradation.

Abstract: The present invention provides a means to modulate gene expression in vivo in a manner that avoids problems associated with CRISPR endogenous protein knock-out or knock-in strategies and strategies that provide for correction, or alteration, of single nucleotides. The invention includes inserting into the genome a nucleotide encoding a heterobifunctional compound targeting protein (dTAG) in-frame with the nucleotide sequence of a gene encoding an endogenously expressed protein of interest which, upon expression, produces an endogenous protein-dTAG hybrid protein. This allows for targeted protein degradation of the dTAG and the fused endogenous protein using a heterobifunctional compound.

Abstract: This invention provides compounds that have spirocyclic E3 Ubiquitin Ligase targeting moieties (Degrons), which can be used as is or linked to a targeting ligand for a protein that has been selected for in vivo degradation, and methods of use and compositions thereof as well as methods for their preparation.