Abstract: A spray-dried dispersions and pharmaceutical composition of (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the spray-dried dispersion and pharmaceutical composition in the treatment of cancer and autoimmune and inflammatory diseases are disclosed. Also provided are crystalline forms of (S)-5-amino-3-(4-((5-fluoro-2-methoxy-benzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide also useful in the treatment of cancer and autoimmune and inflammatory diseases.

Abstract: A spray-dried dispersions and pharmaceutical composition of (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide, pharmaceutically acceptable salts thereof, or a combination thereof and the use of the spray-dried dispersion and pharmaceutical composition in the treatment of cancer and autoimmune and inflammatory diseases are disclosed. Also provided are crystalline forms of (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide also useful in the treatment of cancer and autoimmune and inflammatory diseases.

Abstract: Disclosed herein is an integrated pump system in which a motor is directly coupled to a pump, preferably using a modular connection. The integrated pump system may operate in a uni-directional or bi-directional mode. The integrated pump system incorporates an internal cooling channel which directs the returning low pressure hydraulic fluid past the controller and the motor for cooling purposes. The low pressure hydraulic fluid is also directly fed into the coupling between the motor and the pump to provide both cooling and lubrication.

Abstract: A method for peening an obstructed region of a metal assembly that is obstructed by an obstructing part of the metal assembly is provided. The method includes determining an optimal peening path for treating the obstructed region irrespective of the obstructing part; identifying a portion of the obstructing part within the optimal peening path; determining a section of the portion of the obstructing part that is removable without affecting a mechanical integrity and functionality of the obstructing part; removing, by machining, the section so as to create additional space along the optimal peening path; and peening the obstructed region, a path of the peening at least partially crossing through the additional space. A method for peening a nuclear reactor pressure vessel is also provided.

Abstract: Disclosed herein is an integrated pump system in which a motor is directly coupled to a pump, preferably using a modular connection. The integrated pump system may operate in a uni-directional or bi-directional mode. The integrated pump system incorporates an internal cooling channel which directs the returning low pressure hydraulic fluid past the controller and the motor for cooling purposes. The low pressure hydraulic fluid is also directly fed into the coupling between the motor and the pump to provide both cooling and lubrication.

Abstract: A method for peening an obstructed region of a metal assembly that is obstructed by an obstructing part of the metal assembly is provided. The method includes determining an optimal peening path for treating the obstructed region irrespective of the obstructing part; identifying a portion of the obstructing part within the optimal peening path; determining a section of the portion of the obstructing part that is removable without affecting a mechanical integrity and functionality of the obstructing part; removing, by machining, the section so as to create additional space along the optimal peening path; and peening the obstructed region, a path of the peening at least partially crossing through the additional space. A method for peening a nuclear reactor pressure vessel is also provided.