Abstract: A method for quantifying ribonucleic acid (RNA) mutation expression. For each read pair of a read pair group, a set of contiguously aligned regions and a splice junction configuration are identified. Each read pair is within a selected range of a location of interest. Each read pair of the read pair group is classified based on the set of contiguously aligned regions and the splice junction configuration that correspond to each read pair, a reference genome, and a selected mutation. A mutation-centric output is generated for the read pair group.

Abstract: A portable, self-contained beverage apparatus includes a container assembly having a known storage capacity for storing a consumable liquid, and a dispensing assembly disposed within the container assembly that dispenses variable, non-zero quantities of additives into the consumable liquid. The dispensing assembly includes multiple apertures structured and arranged to retain vessels containing the additives to be dispensed into the consumable liquid. The beverage apparatus also includes a level sensor disposed within the container assembly that determines a consumable liquid level of the consumable liquid stored in the container assembly. In certain embodiments, one or more positive displacement pumping mechanisms are configured to pump additive liquid from additive containers into a beverage chamber.

Abstract: A delivery device for cardiac valve repair implants includes a delivery catheter and an extension member protruding from a distal end of the delivery catheter. The delivery device further includes a control arm assembly having pairs of control arms. Each pair includes a proximal control arm drivable from a handle assembly of the delivery device and a distal arm coupled to a distal end of the proximal control arm and a distal end of the extension member. Proximally driving each of the proximal control arms of the control arm assembly results in expansion of the control arm assembly and corresponding expansion of a cardiac valve repair implant coupled to the control arm assembly.

Abstract: The invention is directed to isolated renal cells, including tubular and erythropoietin (EPO)-producing kidney cell populations, and methods of isolating and culturing the same, as well as methods of treating a subject in need with the cell populations.

Abstract: Optimizations are provided for reliably configuring an on-premise server using configuration data stored at a cloud-based service. An on-premise server polls the cloud-based service to determine whether any new configuration changes are available for the on-premise server to implement. In response to an indication that a new configuration change is available for the on-premise server, the on-premise server performs a validation to determine whether the new configuration change is committable by the on-premise server. Afterwards, the on-premise server receives the new configuration change and then attempts to commit to that new configuration change.

Abstract: Optimizations are provided for reliably configuring an on-premise server using configuration data stored at a cloud-based service. An on-premise server polls the cloud-based service to determine whether any new configuration changes are available for the on-premise server to implement. In response to an indication that a new configuration change is available for the on-premise server, the on-premise server performs a validation to determine whether the new configuration change is committable by the on-premise server. Afterwards, the on-premise server receives the new configuration change and then attempts to commit to that new configuration change.

Abstract: A method that enables multiple spam detection solutions to be deployed in a manageable and rational manner to determine if a message is spam is presented. A framework invokes anti-spam filters to analyze the message and return confidence levels of whether a message is spam. The framework evaluates the highest confidence level against a set of defined thresholds. If the highest confidence level is greater than the highest threshold set by the administrator, the action specified for the highest threshold is taken. The highest confidence level is also compared against all thresholds and the action associated with the nearest threshold that has been exceeded is taken.

Abstract: The present invention enables an electronic message to be distributed sequentially to selected recipients. The electronic message is associated with a routing map, which defines the route of the electronic message. The routing map includes a list of operations, at least some of which are implemented in script. A routing engine controls the current state and the state transition of the routing map while predefined routing objects assist in the manipulation and processing of the routing map. Routing maps are associated with folders and any electronic message dropped in the folder is associated with the routing map. The operations of the routing map are executed in a stateful manner in response to events occurring in the messaging system until the electronic message has been sequentially distributed to the intended recipients.

Abstract: A method that enables multiple spam detection solutions to be deployed in a manageable and rational manner to determine if a message is spam is presented. A framework invokes one or more anti-spam filters to analyze the message and return a confidence level of whether a message is spam and that confidence level is added to a summary of confidence levels. The framework evaluates a summary of confidence levels against a set of defined thresholds. If the summary of confidence levels is greater than the highest threshold set by the administrator, the action specified for the highest threshold is taken. Otherwise, subsequent filters are used to evaluate the message until either the maximum threshold is exceeded or all filters have evaluated the message. After all filters have evaluated the message, the summary of confidence levels is compared against all thresholds and the action associated with that matching threshold is taken.

Abstract: A method that enables multiple spam detection solutions to be deployed in a manageable and rational manner to determine if a message is spam is presented. A framework invokes anti-spam filters to analyze the message and return confidence levels of whether a message is spam. The framework evaluates the highest confidence level against a set of defined thresholds. If the highest confidence level is greater than the highest threshold set by the administrator, the action specified for the highest threshold is taken. The highest confidence level is also compared against all thresholds and the action associated with the nearest threshold that has been exceeded is taken.

Abstract: A method that enables multiple spam detection solutions to be deployed in a manageable and rational manner to determine if a message is spam is presented. A framework invokes one or more anti-spam filters to analyze the message and return a confidence level of whether a message is spam and that confidence level is added to a summary of confidence levels. The framework evaluates a summary of confidence levels against a set of defined thresholds. If the summary of confidence levels is greater than the highest threshold set by the administrator, the action specified for the highest threshold is taken. Otherwise, subsequent filters are used to evaluate the message until either the maximum threshold is exceeded or all filters have evaluated the message. After all filters have evaluated the message, the summary of confidence levels is compared against all thresholds and the action associated with that matching threshold is taken.

Abstract: The present invention enables an electronic message to be distributed sequentially to selected recipients. The electronic message is associated with a routing map, which defines the route of the electronic message. The routing map includes a list of operations, at least some of which are implemented in script. A routing engine controls the current state and the state transition of the routing map while predefined routing objects assist in the manipulation and processing of the routing map. Routing maps are associated with folders and any electronic message dropped in the folder is associated with the routing map. The operations of the routing map are executed in a stateful manner in response to events occurring in the messaging system until the electronic message has been sequentially distributed to the intended recipients.

Abstract: The present invention enables an electronic message to be distributed sequentially to selected recipients. The electronic message is associated with a routing map, which defines the route of the electronic message. The routing map includes a list of operations, at least some of which are implemented in script. A routing engine controls the current state and the state transition of the routing map while predefined routing objects assist in the manipulation and processing of the routing map. Routing maps are associated with folders and any electronic message dropped in the folder is associated with the routing map. The operations of the routing map are executed in a stateful manner in response to events occurring in the messaging system until the electronic message has been sequentially distributed to the intended recipients.