Patents by Inventor Andrew J. Wand

Andrew J. Wand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conformational entropy in molecular recognition
    Patent number: 8652790
    Abstract: The present invention provides methods for the determination of the degree of molecular recognition of a protein with a ligand, including a first protein with a second protein. The methods may comprise determining the squared generalized order parameter (hereinafter, O) for at least one intramolecular bond of the first protein. The protein is then formed into a complex with a ligand. The value or values of O2 for the said at least one bond of the protein is then determined while the protein and the ligand are in the complex. The O value or values determined for the protein while the protein and the ligand are in a complex are compared or related to the O value or values determined for the uncomplexed protein.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: February 18, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Kathleen G. Valentine, Michael Marlow, Andrew J. Wand, Kendra K. Frederick
  • CONFORMATIONAL ENTROPY IN MOLECULAR RECOGNITION
    Publication number: 20100285608
    Abstract: The present invention provides methods for the determination of the degree of molecular recognition of a protein with a ligand, including a first protein with a second protein. The methods may comprise determining the squared generalized order parameter (hereinafter, O) for at least one intramolecular bond of the first protein. The protein is then formed into a complex with a ligand. The value or values of O2 for the said at least one bond of the protein is then determined while the protein and the ligand are in the complex. The O value or values determined for the protein while the protein and the ligand are in a complex are compared or related to the O value or values determined for the uncomplexed protein.
    Type: Application
    Filed: July 18, 2008
    Publication date: November 11, 2010
    Applicant: The Trustee of the University of Pennsylvania
    Inventors: Kathleen G. Valentine, Michael Marlow, Andrew J. Wand, Kendra K. Frederick
  • Apparatus and method for high pressure NMR spectroscopy
    Patent number: 6362624
    Abstract: The present invention provides a pressure cell for pressurizing materials for use in NMR spectroscopy, comprising a sample tube made of sapphire for placing the material, the tube being closed at one end, a housing for holding the sample tube such that the material in the tube can be pressurized, a cove for closing the housing, the cover having an inlet for pressuring the material, means for sealing the cover to the housing, and means of sealing the housing to the sample tube.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: March 26, 2002
    Assignee: The Research Foundation of State University of New York
    Inventors: Andrew J. Wand, Mark R. Ehrhardt, Jeffrey L. Urbauer
  • Apparatus and method for high pressure NMR spectroscopy
    Patent number: 5977772
    Abstract: A Pressure Cell for pressurizing material for use in NMR spectroscopy, comprising a sample tube made of sapphire for placing the material; the tube being closed at one end, a housing for holding the sample tube such that the material in the tube can be pressurized, a cover for closing the housing, the cover having an inlet for pressuring the material, means of sealing the cover to the housing; and means of sealing the housing to the sample tube.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: November 2, 1999
    Assignee: Research Foundation of State University of New York, The
    Inventors: Andrew J. Wand, Mark R. Ehrhardt, Jeffrey L. Urbauer