Abstract: Methods and apparatus are described herein for fluorescent imaging of a retina using a head-mountable device. The retina is illuminated by a head-mountable device (HMD) with light at an excitation wavelength of a fluorophore in the retina and imaged by the HMD at an emission wavelength of the fluorophore. The direction of gaze of a user of the HMD could be determined from the retinal image. The pattern of vasculature in the retinal image could be used to identify the user of the HMD. Information in the retinal image could be used to determine the medical state of the user and diagnose disease states. Fluorescent agents can be introduced into the vasculature of the wearer of the HMD to facilitate these or other applications of fluorescent imaging of the retina using the HMD.

Abstract: An intra-ocular device includes an electronic lens that can be controlled to control the overall optical power of the device. The device can be installed within a flexible polymeric material shaped to conform to the inside surface of a lens capsule of an eye. Accommodation forces applied to the device and/or polymeric material via the lens capsule can cause a change in the optical power of the device and/or polymeric material. Further, such accommodation forces can be detected by an accommodation sensor of the device and the optical power of the electronic lens can be controlled based on the detected accommodation forces. Operated in this way, the device and polymeric material can restore a degree of accommodation to the eye that is related to existing mechanisms for controlling such accommodation, i.e., forces exerted by the eye via the lens capsule.

Abstract: Methods and apparatus are described herein for fluorescent imaging of a retina using a head-mountable device. The retina is illuminated by a head-mountable device (HMD) with light at an excitation wavelength of a fluorophore in the retina and imaged by the HMD at an emission wavelength of the fluorophore. The direction of gaze of a user of the HMD could be determined from the retinal image. The pattern of vasculature in the retinal image could be used to identify the user of the HMD. Information in the retinal image could be used to determine the medical state of the user and diagnose disease states. Fluorescent agents can be introduced into the vasculature of the wearer of the HMD to facilitate these or other applications of fluorescent imaging of the retina using the HMD.

Abstract: An intra-ocular device includes an electronic lens that can be controlled to control the overall optical power of the device. The device can be installed within a flexible polymeric material shaped to conform to the inside surface of a lens capsule of an eye. Accommodation forces applied to the device and/or polymeric material via the lens capsule can cause a change in the optical power of the device and/or polymeric material. Further, such accommodation forces can be detected by an accommodation sensor of the device and the optical power of the electronic lens can be controlled based on the detected accommodation forces. Operated in this way, the device and polymeric material can restore a degree of accommodation to the eye that is related to existing mechanisms for controlling such accommodation, i.e., forces exerted by the eye via the lens capsule.

Abstract: Functionalized particles in the blood are able to selectively bind to targets in the blood that have adverse health effects. The binding of the particles to the targets allows the targets to be selectively modified or destroyed by energy from outside the body such that the adverse health effects are reduced or eliminated. The energy is generated by a wearable device which is able to direct the energy into the subsurface vasculature of the wearer of the wearable device. Further, one or more of the functionalized particles may be magnetic, allowing a magnetic field generated by the wearable device and directed into the subsurface vasculature to concentrate the bound targets in a lumen of the subsurface vasculature proximate to the wearable device.

Abstract: A device includes a capsule sized to pass through a lumen of a gastrointestinal tract, a plurality of functionalized particles disposed within the capsule, one or more tissue penetrating members configured to puncture a wall of the lumen of the intestinal tract; and an actuator having a first configuration and a second configuration. The actuator is configured to retain the plurality of functionalized particles within the capsule in the first configuration. The actuator is further configured to advance the plurality of functionalized particles from the capsule into a wall of the lumen of the gastrointestinal tract via the one or more tissue penetrating members by the actuator transitioning from the first configuration to the second configuration. Systems including the device and methods of delivering functionalized particles to the body are also provided.