Abstract: The present invention relates to the field of pharmaceutical compositions. More particularly it is directed to pharmaceutical compositions comprising an antibody molecule, more particularly a Fab-PEG or a Fab?-PEG molecule, e.g., at high concentrations, and to methods of producing such formulations. Pharmaceutical compositions according to the invention can be lyophilised and are stable upon storage at a temperature from about 2 to 25° C. for an appropriate period of time.

Abstract: The present invention relates to the use of limited amounts of cysteine and tryptophan in the cell culture medium during production of recombinant proteins, and in particular antibodies. Proteins and antibodies produced under such controlled conditions exhibit reduced heterogeneity, in particular reduced charge variants heterogeneity.

Abstract: The present invention relates to the use of limited amounts of cysteine and tryptophan in the cell culture medium during production of recombinant proteins, and in particular antibodies. Proteins and antibodies produced under such controlled conditions exhibit reduced heterogeneity, in particular reduced charge variants heterogeneity.

Abstract: Systems and methods for providing multimedia content from one process or component to another process or component over an unsecured connection are provided. One embodiment includes obtaining the cryptographic information, extracting the at least partially encrypted video data from the container file to create an elementary bitstream, enciphering the cryptographic information, inserting the cryptographic information in the elementary bitstream, providing the elementary bitstream to a video decoder, extracting the cryptographic information from the elementary bitstream at the video decoder, deciphering the cryptographic information, decrypting the elementary bitstream with the cryptographic information and decoding the elementary bitstream for rendering on a display device using the video decoder.

Abstract: The present invention relates to the use of limited amounts of cysteine and tryptophan in the cell culture medium during production of recombinant proteins, and in particular antibodies. Proteins and antibodies produced under such controlled conditions exhibit reduced heterogeneity, in particular reduced charge variants heterogeneity.

Abstract: An example system coupled to a rollator for monitoring usage of the rollator, includes a grip assembly and/or a hip sensing assembly. The grip assembly includes a first sensor configured to detect a force applied to the first sensor. The hip sensing assembly includes a second sensor configured to measure a distance between the second sensor and a hip of the user positioned with respect to the rollator. A microcontroller is electronically coupled in signal communication with the first sensor, the second sensor, and a feedback circuitry. When the force applied to the first sensor exceeds a first threshold, the microcontroller activates the feedback circuitry to generate a first response indicating that the first threshold has been exceeded. When the distance exceeds a second threshold, the microcontroller activates the feedback circuitry to generate a second response indicating that the second threshold has been exceeded.

Abstract: The present invention relates to pharmaceutical compositions comprising from an antibody or a fragment thereof which binds IL-17A and IL-17F and a combination of glycine, acetate buffer at pH 4.6 to 5.5 and polysorbate 80.

Abstract: The present invention relates to pharmaceutical compositions comprising from an antibody or a fragment thereof which binds IL-17A and IL-17F and a combination of glycine, acetate buffer at pH 4.6 to 5.5 and polysorbate 80.

Abstract: A rehosted flight operation system is disclosed. The system comprises one or more controllers configured to execute program instructions. The program instructions include a rehosted flight operation module configured to generate one or more emulated flight operation subsystems, and a host flight operation module configured to generate flight operation data and flight operation commands.

Abstract: A vendor of virtual machine images accesses a virtual computer system service to upload a digitally signed virtual machine image to a data store usable by customers of the virtual computer system service to select an image for creating a virtual machine instance. If a digital certificate is uploaded along with the virtual machine image, the virtual computer system service may determine whether the digital certificate has been trusted for use. If the digital certificate has been trusted for use, the virtual computer system service may use a public cryptographic key to decrypt a hash signature included with the image to obtain a first hash value. The service may additionally apply a hash function to the image itself to obtain a second hash value. If the two hash values match, then the virtual machine image may be deemed to be authentic.

Abstract: The invention relates to a liquid pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof, cyclodextrin and methionine. In addition, it relates to a method for reducing precipitation of an antibody or an antigen-bindmg fragment thereof in a liquid pharmaceutical formulation through addition of methionine and cyclodextrin. In particular, the liquid pharmaceutical formulations comprises an anti-sclerostin antibody, hydroxypropyl-gamma cyclodextrin and methionine and may be used in the treatment of a bone disorder associated with at least one of low bone formation, low bone mineral density, low bone mineral content, low bone mass, low bone quality and low bone strength, and especially for treating osteoporosis.

Abstract: A vendor of virtual machine images accesses a virtual computer system service to upload a digitally signed virtual machine image to a data store usable by customers of the virtual computer system service to select an image for creating a virtual machine instance. If a digital certificate is uploaded along with the virtual machine image, the virtual computer system service may determine whether the digital certificate has been trusted for use. If the digital certificate has been trusted for use, the virtual computer system service may use a public cryptographic key to decrypt a hash signature included with the image to obtain a first hash value. The service may additionally apply a hash function to the image itself to obtain a second hash value. If the two hash values match, then the virtual machine image may be deemed to be authentic.

Abstract: The invention relates to a liquid pharmaceutical formulation comprising an antibody or antigen-binding fragment thereof, cyclodextrin and methionine. In addition, it relates to a method for reducing precipitation of an antibody or an antigen-binding fragment thereof in a liquid pharmaceutical formulation through addition of methionine and cyclodextrin. In particular, the liquid pharmaceutical formulations comprises an anti-sclerostin antibody, hydroxypropyl-gamma cyclodextrin and methionine and may be used in the treatment of a bone disorder associated with at least one of low bone formation, low bone mineral density, low bone mineral content, low bone mass, low bone quality and low bone strength, and especially for treating osteoporosis.

Abstract: The present invention relates to pharmaceutical compositions comprising an antibody or a fragment thereof suitable for freeze-drying (i.e. lyophilizing). The pharmaceutical compositions, which comprise an antibody or an antigen-binding fragment thereof; from 1% to 20% w/v sucrose; an amino acid or a mixture of amino acids; and surfactant, are provided as pharmaceutical compositions for freeze-drying; as freeze-dried (i.e. lyophilized) compositions which can be reconstituted into a solvent at the time of use or as reconstituted liquid formulations ready for administration.

Abstract: A rehosted flight operation system is disclosed. The system comprises one or more controllers configured to execute program instructions. The program instructions include a rehosted flight operation module configured to generate one or more emulated flight operation subsystems, and a host flight operation module configured to generate flight operation data and flight operation commands.

Abstract: An example system coupled to a rollator for monitoring usage of the rollator, includes a grip assembly and/or a hip sensing assembly. The grip assembly includes a first sensor configured to detect a force applied to the first sensor. The hip sensing assembly includes a second sensor configured to measure a distance between the second sensor and a hip of the user positioned with respect to the rollator. A microcontroller is electronically coupled in signal communication with the first sensor, the second sensor, and a feedback circuitry. When the force applied to the first sensor exceeds a first threshold, the microcontroller activates the feedback circuitry to generate a first response indicating that the first threshold has been exceeded. When the distance exceeds a second threshold, the microcontroller activates the feedback circuitry to generate a second response indicating that the second threshold has been exceeded.

Abstract: An example system coupled to a rollator for monitoring usage of the rollator, includes a grip assembly and/or a hip sensing assembly. The grip assembly includes a first sensor configured to detect a force applied to the first sensor. The hip sensing assembly includes a second sensor configured to measure a distance between the second sensor and a hip of the user positioned with respect to the rollator. A microcontroller is electronically coupled in signal communication with the first sensor, the second sensor, and a feedback circuitry. When the force applied to the first sensor exceeds a first threshold, the microcontroller activates the feedback circuitry to generate a first response indicating that the first threshold has been exceeded. When the distance exceeds a second threshold, the microcontroller activates the feedback circuitry to generate a second response indicating that the second threshold has been exceeded.

Abstract: Systems and methods for providing multimedia content from one process or component to another process or component over an unsecured connection are provided. One embodiment includes obtaining the cryptographic information, extracting the at least partially encrypted video data from the container file to create an elementary bitstream, enciphering the cryptographic information, inserting the cryptographic information in the elementary bitstream, providing the elementary bitstream to a video decoder, extracting the cryptographic information from the elementary bitstream at the video decoder, deciphering the cryptographic information, decrypting the elementary bitstream with the cryptographic information and decoding the elementary bitstream for rendering on a display device using the video decoder.

Abstract: A method and apparatus for distributing cryptographic material are disclosed. In the method and apparatus, cryptographic material is obtained and it is determined that the cryptographic material is to be made available for use by one or more computing resources. The cryptographic material is then sent to one or more secure modules, whereby a secure module of the one or more secure modules is programmatically accessible to a computing resource of the one or more computing resources and programmatic access enables the computing resource to request performance of one or more cryptographic operations using the cryptographic material while exporting the cryptographic material to the computing resource is denied.

Abstract: Systems and methods for providing multimedia content from one process or component to another process or component over an unsecured connection are provided. One embodiment includes obtaining the cryptographic information, extracting the at least partially encrypted video data from the container file to create an elementary bitstream, enciphering the cryptographic information, inserting the cryptographic information in the elementary bitstream, providing the elementary bitstream to a video decoder, extracting the cryptographic information from the elementary bitstream at the video decoder, deciphering the cryptographic information, decrypting the elementary bitstream with the cryptographic information and decoding the elementary bitstream for rendering on a display device using the video decoder.