Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

Abstract: Aspects of a geogrid system and method for improving substrate interactions within a geotechnical environment is disclosed. In one aspect a geotechnical environment is configured with a horizontal multilayer mechanically stabilizing geogrid. In said aspect the geogrid is extruded with a polymeric material and a compressible cellular layer, wherein the geogrid comprises a heightened aspect ratio with a patterned structure of engineered discontinuities and a plurality of strong axes. The combination of elements provides for a system and method of stabilizing soils and aggregate, by resisting lateral movement from the strong axes, and trapping particles in the patterned structure of engineered discontinuities.

Abstract: The invention concerns quinazoline derivatives of formula wherein n is 1, 2 or 3 and each R.sup.2 is independently halogeno; and R.sup.1 is di-?(1-4C)alkyl!amino-(2-4C)alkoxy, pryolidin-1-yl-(2-4C)alkoxy,piperidino-(2-4C)alkoxy, morpholino-(2-4C)alkoxy, piperazin-1-yl-(2-4C)alkoxy or 4-(1-4C)alkylpiperazin-1-yl-(2-4C)alkoxy; or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.