Patents by Inventor Andrew John Blacker

Andrew John Blacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10717754
    Abstract: Metal complexes such as those of formula (I) are contemplated by the present invention. The metal complexes may be used in catalytic reactions as a catalyst. The catalytic reaction may be an autotransfer process, for example hydrogen borrowing. Improved catalytic activity has been observed with certain metal complexes of the invention.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: July 21, 2020
    Assignee: University of Leeds
    Inventors: Stephen Philip Marsden, Patrick Columba McGowan, Roberta Lanaro, Andrew John Blacker
  • Publication number: 20180362566
    Abstract: Metal complexes such as those of formula (I) are contemplated by the present invention. The metal complexes may be used in catalytic reactions as a catalyst. The catalytic reaction may be an autotransfer process, for example hydrogen borrowing.
    Type: Application
    Filed: December 19, 2016
    Publication date: December 20, 2018
    Inventors: Stephen Philip MARSDEN, Patrick Columba MCGOWAN, Roberta LANARO, Andrew John BLACKER
  • Patent number: 7888083
    Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: February 15, 2011
    Assignee: AstraZeneca UK Limited
    Inventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
  • Publication number: 20100209984
    Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
    Type: Application
    Filed: April 27, 2010
    Publication date: August 19, 2010
    Applicant: AstraZeneca UK Limited
    Inventors: Andrew John BLACKER, Christopher David REEVE, Robert Anthony HOLT
  • Patent number: 7732171
    Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: June 8, 2010
    Assignee: AstraZeneca UK Limited
    Inventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
  • Publication number: 20090163719
    Abstract: There is provided a process for the de-enrichment of enantiomerically enriched compositions which comprises reacting an enantiomerically enriched composition comprising at least a first enantiomer or diastereomer of a substrate comprising a carbon-heteroatom bond, wherein the carbon is a chiral centre and the heteroatom is a group V heteroatom, in the presence of a catalyst system and optionally a reaction promoter to give a product composition comprising first and second enantiomers or diastereomers of the substrate having a carbon-heteroatom bond, the ratio of second to first enantiomer or diastereomer in the product composition being greater than the ratio of second to first enantiomer or diastereomer in the enantiomerically enriched composition.
    Type: Application
    Filed: October 27, 2005
    Publication date: June 25, 2009
    Inventors: Andrew John Blacker, Matthew John Stirling
  • Publication number: 20080280336
    Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
    Type: Application
    Filed: July 23, 2008
    Publication date: November 13, 2008
    Applicant: ASTRAZENECA UK LIMITED
    Inventors: Andrew John Blacker, Christopher David Reeve, Robert Anthony Holt
  • Patent number: 7416865
    Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: August 26, 2008
    Assignee: AstraZeneca UK Limited
    Inventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
  • Patent number: 7250526
    Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally substituted sulphonated hydrocarbyl group, a sulphonated perhalogenated hydrocarbyl group, or an optionally substituted sulphonated heterocyclyl group. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centres. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: July 31, 2007
    Assignee: NPIL Pharmaceuticals (UK) Limited
    Inventors: Andrew John Blacker, Christian Bubert, Jonathan Michael Jeremy Williams, Stephen Martin Brown
  • Patent number: 7157255
    Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: January 2, 2007
    Assignee: AstraZeneca UK Limited
    Inventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
  • Patent number: 7138548
    Abstract: A process for the preparation of a compound of formula (I): wherein Ar represents an optionally substituted aromatic carbocycle or heterocycle, and R1 and R2 independently represent hydrogen, C1-10 alkyl, C(O)C1-10 alkyl or optionally substituted aryl provided that R1 and R2 are not both hydrogen which process comprises reacting together a compound of formula (II): Ar—X??(II) wherein Ar is as defined in relation to formula (I) and X represents a leaving group with a a compound of formula (III) wherein R1 and R2 are as defined in relation to formula (I) under aqueous conditions in the presence of a Pd (II) salt, a ligand and a Group I or Group II metal hydroxide base at a pH greater than 7. Compounds of formula (I) may be hydrolysed to the corresponding hydrazine.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: November 21, 2006
    Assignee: Avecia Limited
    Inventors: Andrew John Blacker, David Dodman, David Anthony Jackson, Jan Michael Fielden, John Heathcote Atherton
  • Patent number: 7022876
    Abstract: A process is provided for the preparation of mandelic acid derivatives. The process comprises the steps of: (a) stereoselectively cyanating a compound of Formula (2) to yield the corresponding cyanohydrin; (b) hydrolyzing the product of step (a) to the corresponding compound of Formula (1). wherein X is a substituent.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: April 4, 2006
    Assignee: Avecia Ltd.
    Inventors: Andrew John Blacker, Ian Nicholas Houson
  • Publication number: 20040254391
    Abstract: A process is provided for the preparation of a compound of Formula (1) 1
    Type: Application
    Filed: July 19, 2004
    Publication date: December 16, 2004
    Inventors: Andrew John Blacker, Ian Nicholas Houson, Jonathan William Wiffen
  • Publication number: 20040102313
    Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally substituted sulphonated hydrocarbyl group, a sulphonated perhalogenated hydrocarbyl group, or an optionally substituted sulphonated heterocyclyl group. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centres. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.
    Type: Application
    Filed: October 15, 2003
    Publication date: May 27, 2004
    Inventors: Andrew John Blacker, Christian Bubert, Jonathan Michael Jeremy Williams, Stephen Martin Brown
  • Publication number: 20040068140
    Abstract: A process is provided for the preparation of mandelic acid derivatives.
    Type: Application
    Filed: August 5, 2003
    Publication date: April 8, 2004
    Inventors: Andrew John Blacker, Ian Nicholas Houson
  • Publication number: 20030134900
    Abstract: A process is provided for the preparation of a compound of formula (1) 1
    Type: Application
    Filed: November 1, 2002
    Publication date: July 17, 2003
    Inventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
  • Patent number: 6545188
    Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal cyclopentadienyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centers. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: April 8, 2003
    Assignee: Avecia Limited
    Inventors: Andrew John Blacker, Ben James Mellor
  • Patent number: 6509467
    Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal neutral hydrocarbyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centers. The hydrogen donor is advantageously a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate iminium salts, which are preferably prochiral.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: January 21, 2003
    Assignee: Avecia Limited
    Inventors: Andrew John Blacker, Lynne Alison Campbell
  • Publication number: 20020156282
    Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal cyclopentadienyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centers. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.
    Type: Application
    Filed: February 27, 2002
    Publication date: October 24, 2002
    Applicant: Avecia Limited
    Inventors: Andrew John Blacker, Ben James Mellor
  • Patent number: 6372931
    Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal cyclopentadienyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centers. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: April 16, 2002
    Assignee: Avecia Limited
    Inventors: Andrew John Blacker, Ben James Mellor