Patents by Inventor Andrew John George Simpson

Andrew John George Simpson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic active peptide fragments
    Patent number: 10617746
    Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (SM14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic compositions and diagnostic kits using peptide fragments.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: April 14, 2020
    Assignee: Fundaçao Oswaldo Cruz—FIOCRUZ
    Inventors: Miriam Tendler, Richard Charles Garratt, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Mônica Magno Vilar, Marilia Sirianni dos Santos Almeida
  • SYNTHETIC ACTIVE PEPTIDE FRAGMENTS
    Publication number: 20170232082
    Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (SM14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic compositions and diagnostic kits using peptide fragments.
    Type: Application
    Filed: April 28, 2017
    Publication date: August 17, 2017
    Applicant: Fundaçao Oswaldo Cruz - FIOCRUZ
    Inventors: Miriam Tendler, Richard Charles Garratt, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Mônica Magno Vilar, Marilia Sirianni dos Santos Almeida
  • Synthetic active peptide fragments
    Patent number: 9670256
    Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (SM14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic compositions and diagnostic kits using peptide fragments.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: June 6, 2017
    Assignee: Fundacao Oswaldo Cruz-FIOCRUZ
    Inventors: Miriam Tendler, Richard Charles Garratt, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Mônica Magno Vilar, Marilia Sirianni dos Santos Almeida
  • Targeted treatment for patients with estrogen receptor negative and progesterone receptor negative breast cancers
    Patent number: 9314515
    Abstract: Treatments for estrogen receptor and progesterone receptor negative breast cancer or estrogen receptor, progesterone receptor and c-erbB2 negative (triple negative) breast cancer are provided.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: April 19, 2016
    Assignee: Ludwig Institute for Cancer Research Ltd.
    Inventors: Anita Grigoriadis, Otavia L. Caballero, Andrew John George Simpson
  • SYNTHETIC ACTIVE PEPTIDE FRAGMENTS
    Publication number: 20150064211
    Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (SM14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic compositions and diagnostic kits using peptide fragments.
    Type: Application
    Filed: November 12, 2014
    Publication date: March 5, 2015
    Applicant: FUNDAÇAO OSWALDO CRUZ - FIOCRUZ
    Inventors: Miriam Tendler, Richard Charles Garratt, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Mônica Magno Vilar, Marilia Sirianni dos Santos Almeida
  • Direct or indirect diagnostic test for helminth infection
    Patent number: 8909483
    Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using peptide fragments of the present invention.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: December 9, 2014
    Assignee: Fundação Oswaldo Cruz—FIOCRUZ
    Inventors: Miriam Tendler, Richard Charles Garratt, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Mônica Magno Vilar, Marilia Sirianni dos Santos Almeida
  • Synthetic active peptide fragments
    Patent number: 8321143
    Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using peptide fragments.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: November 27, 2012
    Inventors: Miriam Tendler, Richard Charles Garrat, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Monica Magno Vilar, Marilia Sirianni dos Santo Almeida
  • TARGETED TREATMENT FOR PATIENTS WITH ESTROGEN RECEPTOR NEGATIVE AND PROGESTERONE RECEPTOR NEGATIVE BREAST CANCERS
    Publication number: 20110150935
    Abstract: Treatments for estrogen receptor and progesterone receptor negative breast cancer or estrogen receptor, progesterone receptor and c-erbB2 negative (triple negative) breast cancer are provided.
    Type: Application
    Filed: April 22, 2009
    Publication date: June 23, 2011
    Inventors: Anita Grigoriadis, Otavia L. Caballero, Andrew John George Simpson
  • CANCER-TESTIS GENE SILENCING AGENTS AND USES THEREOF
    Publication number: 20110082185
    Abstract: The invention relates to methods, formulations and kits useful for inhibiting cancer cell viability, invasion, or migration.
    Type: Application
    Filed: September 16, 2008
    Publication date: April 7, 2011
    Applicant: Ludwig Institute for Cancer Research Ltd.
    Inventors: Otavia L. Caballero, Tzeela Cohen, Andrew John George Simpson
  • SYNTHETIC ACTIVE PEPTIDE FRAGMENTS
    Publication number: 20090312522
    Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the said peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using said peptide fragments.
    Type: Application
    Filed: January 8, 2009
    Publication date: December 17, 2009
    Inventors: Miriam Tendler, Richard Charles Garrat, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Monica Magno Vilar, Marilia Sirianni dos Santo Almeida
  • Synthetic active peptide fragments
    Publication number: 20040006204
    Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the said peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using said peptide fragments.
    Type: Application
    Filed: April 2, 2002
    Publication date: January 8, 2004
    Inventors: Miriam Tendler, Richard Charles Garrat, Naftale Katz, Andrew John George Simpson, Frank Jefferson Alarcon de Barrientos, Monica Magno Vilar, Marilia Sirianni dos Santo Almeida
  • METHOD FOR DETERMINING NUCLEOTIDE SEQUENCES USING ARBITRARY PRIMERS AND LOW STRINGENCY
    Publication number: 20020155438
    Abstract: The invention involves a method for obtaining sequence information from nucleic acid molecules, such as cDNA. The method involves the use of arbitrary primers, and low stringency conditions. Rather than providing information from the termini of nucleic molecules, the method provides information on the more interesting and relevent internal portions of nucleic acid molecules. The method shows how to secure information on ORFs, and how to prepare contig sequences from any source.
    Type: Application
    Filed: September 27, 1999
    Publication date: October 24, 2002
    Inventors: ANDREW JOHN GEORGE SIMPSON, EMMANUEL DIAS NETO, RICARDO RENZO BRENTANI
  • METHOD FOR DETERMINING NUCLEOTIDE SEQUENCES USING ARBITRARY PRIMERS AND LOW STRINGENCY
    Publication number: 20020068277
    Abstract: The invention involves a method for obtaining nucleotide sequence information from nucleic acid molecules, such as cDNA. The method involves the use of arbitrary primers, and low stringency conditions. Rather than providing information from the termini of nucleic acid molecules, the method provides information on the more interesting and relevant internal portions of nucleic acid molecules. The method shows how to secure information on ORFs, and how to prepare contig sequences from any source.
    Type: Application
    Filed: November 20, 1998
    Publication date: June 6, 2002
    Inventors: ANDREW JOHN GEORGE SIMPSON, EMMANUEL DIAS NETO, RICARDO RENZO BRENTANI