Abstract: This application relates to substituted benzimidazoles, compositions comprising them and their uses in the treatment of diseases and conditions in which inhibition of a bromodomain is indicated. For example, the application relates to substituted benzimidazoles and to their use as bromodomain inhibitors. The present application is also related to the treatment or prevention of proliferative disorders, auto-immune disorders, inflammatory disorders, dermal disorders, and neoplasms, including tumors and/or cancers.

Abstract: A process for producing a composite material comprising the steps of: providing mm-sized particles comprising at least particles of a porous optionally at least partially compressed open-cell melamine formaldehyde resin and mm-sized particles of at least one non-rigid foamed resin; mixing said particles with at least one reactive adhesive in a concentration of 6 to 18 g of reactive adhesive per 100 g of mm-sized particles; reacting said reactive adhesive with said particles in the presence of aerial moisture thereby bonding said particles together during said mixing process; transporting said mixture into a mould; and irreversibly compressing said mixture to a block in a mould without additional heat to a density greater than 50 kg/m3 to form a block of said composite material; a composite material obtainable by this process; and the use of this composite material for polishing and/or cleaning applications with a liquid.