Patents by Inventor Andrew K.D. YOUNGER

Andrew K.D. YOUNGER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Generation of novel metabolite-responsive transcription regulator biosensors
    Patent number: 10604552
    Abstract: Disclosed are systems, components, and methods for sensing a ligand in a cell or a reaction mixture. The disclosed systems, components, and methods may include and/or utilize a fusion protein comprising a ligand-binding protein and a DNA-binding protein. The fusion protein binds the ligand of the ligand-binding protein and modulates expression of a reporter gene operably linked to a promoter that is engineered to include specific binding sites for the DNA-binding protein. The difference in expression of the reporter gene in the presence of the ligand versus expression of the reporter gene in the absence of the ligand can be correlated to the concentration of the ligand in a reaction mixture.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: March 31, 2020
    Assignee: Northwestern University
    Inventors: Joshua N. Leonard, Andrew K. D. Younger, Keith E. J. Tyo
  • GENERATION OF NOVEL METABOLITE-RESPONSIVE TRANSCRIPTION REGULATOR BIOSENSORS
    Publication number: 20190345209
    Abstract: Disclosed are systems, components, and methods for sensing a ligand in a cell or a reaction mixture. The disclosed systems, components, and methods may include and/or utilize a fusion protein comprising a ligand-binding protein and a DNA-binding protein. The fusion protein binds the ligand of the ligand-binding protein and modulates expression of a reporter gene operably linked to a promoter that is engineered to include specific binding sites for the DNA-binding protein. The difference in expression of the reporter gene in the presence of the ligand versus expression of the reporter gene in the absence of the ligand can be correlated to the concentration of the ligand in a reaction mixture.
    Type: Application
    Filed: October 17, 2017
    Publication date: November 14, 2019
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Joshua N. LEONARD, Andrew K.D. YOUNGER, Keith E.J. TYO