Patents by Inventor Andrew K. Ottens

Andrew K. Ottens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury
    Patent number: 8557526
    Abstract: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: October 15, 2013
    Assignees: University of Florida Research Foundation, Inc., Banyan Biomarkers, Inc.
    Inventors: Andrew K. Ottens, Firas H. Kobaissy, Ka-Wang (Kevin) Wang, Ronald L. Hayes, Zhiqun Zhang, Ming Chen Liu, Monika Oli
  • SYNAPTOTAGMIN AND COLLAPSIN RESPONSE MEDIATOR PROTEIN AS BIOMARKERS FOR TRAUMATIC BRAIN INJURY
    Publication number: 20120196307
    Abstract: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological samples after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (biological samples). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
    Type: Application
    Filed: December 27, 2011
    Publication date: August 2, 2012
    Applicants: Banyan Biomarkers, Inc., University of Florida Research Foundation, Inc.
    Inventors: ANDREW K. OTTENS, Firas H. Kobaissy, Ka-Wang (Kevin) Wang, Ronald L. Hayes, Zhiqun Zhang, Ming Chen Liu, Monika Oli
  • Synaptotagmin and Collapsin Response Mediator Protein as Biomarkers for Traumatic Brain Injury
    Publication number: 20100047817
    Abstract: Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.
    Type: Application
    Filed: August 5, 2009
    Publication date: February 25, 2010
    Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., BANYAN BIOMARKERS, INC.
    Inventors: Andrew K. Ottens, Firas H. Kobaissy, Ka-Wang (Kevin) Wang, Ronald L. Hayes, Zhiqun Zhang, Ming Chen Liu, Monika Oli
  • Biomarkers of liver injury
    Patent number: 7645584
    Abstract: Novel, sensitive and specific markers for diagnostics and monitoring of liver injuries, including, but not limited to ischemic liver damage, are provided. This includes identification several enzymes of arginine/urea/nitric oxide cycle, sulfuration enzymes and spectrin breakdown related products, among others.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: January 12, 2010
    Assignees: University of Florida Research Foundation, Inc., Banyan Biomarkers
    Inventors: Stanislav I. Svetlov, Ronald L. Hayes, Kevin K. W. Wang, Monika Oli, Andrew K. Ottens
  • Real-Time Assessment of Biomarkers for Disease
    Publication number: 20080204043
    Abstract: A system and methods, thereof, monitor biomarkers from a patient suffering from neural injury in real-time. The system comprises a quartz crystal microbalance wherein a capture molecule specific for certain biomarkers is diagnostic of the type of neural injury, location of neural injury and the degree of severity of neural injury. The system, in particular, provides real-time continuous monitoring of a patient.
    Type: Application
    Filed: October 27, 2005
    Publication date: August 28, 2008
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: Kevin K.W. Wang, Andrew K. Ottens