Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A mobile home system having a trailer having a chassis and tongue, at least one axle, and providing a trailer platform. A mobile home structure is secured to the trailer. The structure having a laminate floor portion; a roof portion, and rafters and bottom plates; and a wall portion positioned between the floor portion and the roof portion. The wall portion has at least one wall with a top plate, a sill plate and studs extended therebetween, and internal sheathing panels. Each stud providing at least one tenon on an internal face; and each interior sheathing panel applied to the interior edge face of the plurality of studs, with each interior sheathing panel having a plurality of mortises configured to receive one of the tenons of each stud, to form a mortise-tenon connection.

Abstract: One embodiment of the present invention sets forth a data pipeline, which includes a first mousetrap element and a second mousetrap element in a first pipeline stage. Each mousetrap element includes a request latch that, when enabled, allows a request signal to pass from the first pipeline stage to a second pipeline stage following the first pipeline stage in the data pipeline. Each mousetrap element also includes a data latch that, when enabled, allows a data element to pass from the first pipeline stage to the second pipeline stage. Each mousetrap element further includes a latch controller that enables and disables the request and data latches based on a phase signal that alternates between a first value that configures the first mousetrap element to transmit data to the second pipeline stage and a second value that configures the second mousetrap element to transmit data to the second pipeline stage.

Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: Implementations are described herein for commissioning a distributed control node (DCN) to a process automation network. In various implementations, one or more messages transmitted on the process automation network by the DCN announcing that the DCN has joined the process automation network may be detected. Based on the one or more messages, one or more operational technology (OT) capabilities of the DCN may be determined. Based on the one or more OT capabilities, the DCN may be commissioned to the process automation network, e.g., by configuring the DCN to cooperate with one or more other process automation nodes on the process automation network to implement an at least partially automated process.

Abstract: A modular shelter, is provided having an assembly of at least one each of a modular wall panel, modular floor portion, and modular roof panel. The modular wall panel having a sill plate, top plate, plurality of vertical studs extending therebetween, and a skin with a first edge having a waveform profile for connecting to an adjacent modular panel; and one of the vertical studs being an end stud and having a first connector element configured to be secured to a first complementing connector element of an adjacent second modular panel; and further each modular roof panel has a peak crosspiece, bottom crosspiece, and plurality of rafters, with the first rafter having an engagement member to be engaged with a complementary engagement member of another modular roof panel, and further a second connector element configured to be secured to a second complementing connector element of a second modular roof panel.

Abstract: A mobile home system is provided having: a trailer having a chassis and tongue, at least one axle, and providing a trailer platform. A mobile home structure is secured to the trailer. The structure having a laminate floor portion; a roof portion with a ridge beam, and rafters extending away from the ridge beam, and bottom plates positioned at each end of the rafters; and a wall portion positioned between the floor portion and the roof portion. The wall portion has at least one wall with a top plate, a sill plate and studs extended therebetween, and internal sheathing panels.

Abstract: To facilitate crosstalk analysis for an IC design, a plurality of input vectors are input into a gate-level simulation. In response, the gate-level simulation determines timing windows for all nets within the IC design, may perform aggressor pruning, and may then determine and output aggressor/victim pairs and associated features for the IC design. This gate-level simulation may be accelerated utilizing one or more graphics processor units (GPUs). Additionally, the aggressor/victim pairs and associated features for the IC design are then input into a trained machine learning environment, which outputs predicted delta delays for each of the aggressor/victim pairs. In this way, crosstalk analysis may be performed more accurately and efficiently.

Abstract: A modular panel is provided and includes a sill plate, a top plate, a plurality of vertical studs, and having at least one skin applied to a major face of the modular panel that presents a first edge having a waveform profile configured to connect to an opposing edge of an adjacent modular panel. At least one of the vertical studs is an end stud having a connector element configured to be secured to a complementing connector of the adjacent modular panel. Two or more of the modular panels may be connected together to form part of a shelter.

Abstract: One embodiment of the present invention sets forth a data pipeline, which includes a first mousetrap element and a second mousetrap element in a first pipeline stage. Each mousetrap element includes a request latch that, when enabled, allows a request signal to pass from the first pipeline stage to a second pipeline stage following the first pipeline stage in the data pipeline. Each mousetrap element also includes a data latch that, when enabled, allows a data element to pass from the first pipeline stage to the second pipeline stage. Each mousetrap element further includes a latch controller that enables and disables the request and data latches based on a phase signal that alternates between a first value that configures the first mousetrap element to transmit data to the second pipeline stage and a second value that configures the second mousetrap element to transmit data to the second pipeline stage.

Abstract: The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.

Abstract: Implementations are described herein for leveraging an “out-of-band” communication channel between nodes of a process automation system. In various implementations, an out-of-band communication channel may be established between two or more process automation nodes of a process automation system. The out-of-band communication channel may be outside of a process automation network through which the two or more process automation nodes are communicatively coupled with other process automation nodes of the process automation system. The two or more process automation nodes may cooperate with one or more of the other process automation nodes to implement an at least partially automated process. One or more characteristics of the process automation system may be monitored, and based on the monitoring, traffic may be selectively diverted from the process automation network to the out-of-band communication channel.

Abstract: Implementations are described herein for provisioning a device such as a DCN with configuration data for operation on a process automation network using an “out-of-band” communication channel. In various implementations, a temporary out-of-band communication channel may be established between a first and second DCNs. The out-of-band communication channel may be distinct from a process automation network through which the first DCN is to be communicatively coupled with other process automation nodes of a process automation system. Provisioning data may be transmitted from the second DCN to the first DCN over the temporary out-of-band communication channel. The provisioning data may include: information technology (IT) configuration data and operational technology (OT) configuration data. Subsequent to the transmitting, the temporary out-of-band communication channel may be closed.

Abstract: Implementations are described herein for commissioning a device such as a distributed control node (DCN) for operation with a process automation system (PAS) using a portable setup device (PSD) and an “out-of-band” communication channel. In various implementations, static information conveyed by a passive data store of the DCN may be used to establish an out-of-band communication channel between the DCN and PSD. The out-of-band communication channel may be distinct from a process automation network through which the DCN is to be communicatively coupled with other process automation nodes of the PAS. The DCN may be commissioned to the process automation system by exchanging operational technology (OT) data between the DCN and the PSD via the out-of-band communication channel to enable the DCN to cooperate with one or more of the other process automation nodes on the process automation network to implement an at least partially automated process.

Abstract: Implementations are described herein for commissioning a distributed control node (DCN) to a process automation network. In various implementations, one or more messages transmitted on the process automation network by the DCN announcing that the DCN has joined the process automation network may be detected. Based on the one or more messages, one or more operational technology (OT) capabilities of the DCN may be determined. Based on the one or more OT capabilities, the DCN may be commissioned to the process automation network, e.g., by configuring the DCN to cooperate with one or more other process automation nodes on the process automation network to implement an at least partially automated process.

Abstract: Implementations are described herein for leveraging an “out-of-band” communication channel between nodes of a process automation system. In various implementations, an out-of-band communication channel may be established between two or more process automation nodes of a process automation system. The out-of-band communication channel may be outside of a process automation network through which the two or more process automation nodes are communicatively coupled with other process automation nodes of the process automation system. The two or more process automation nodes may cooperate with one or more of the other process automation nodes to implement an at least partially automated process. One or more characteristics of the process automation system may be monitored, and based on the monitoring, traffic may be selectively diverted from the process automation network to the out-of-band communication channel.

Abstract: A headware for computer control includes a body portion. A first arm is pivotally coupled to the body portion and a second arm is pivotably coupled to the body portion. The first arm and the second arm define a central region therebetween. A pivoting mechanism is coupled to the first arm or the second arm and the body portion. The pivoting mechanism pivots the first arm or the second arm towards or away from the central region. The pivoting mechanism includes a pivot pin securing the first arm or the second arm to the body portion. A biasing member biases the first arm or the second arm toward the central region when the first arm or the second arm is pivoted away from the central region.

Abstract: Information for use in a command script for a product dispensing system is compiled by sniffing packets associated with a print job that contains information associated with a product to be dispensed, filtering the packets so as to remove fields not associated with the print job, and combining the filtered packets to generate contiguous data associated with the print job. A command script for a product dispensing system is generated by receiving data associated with a print job that contains information associated with a product to be dispensed, extracting the information associated with the product from the print job data, organizing the information associated with the product into discrete informational units, and generating the command script based on the organized discrete information units.

Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.