Abstract: Bispecific antibody compounds, and methods of using same, are provided which bind and neutralize Dkk-1 and RANKL and which are useful as adjuncts to spinal fusion surgery or as agents for bone healing or treating conditions associated with bone loss or degeneration.

Abstract: Bispecific antibody compounds, and methods of using same, are provided which bind and neutralize Dkk-1 and RANKL and which are useful as adjuncts to spinal fusion surgery or as agents for bone healing or treating conditions associated with bone loss or degeneration.

Abstract: Various embodiments of a system and method for scheduled delivery of shipments with multiple shipment carriers are described. Various embodiments may include a scheduled delivery component configured to receive delivery availability information for multiple shipment carriers. In various embodiments, for each shipment carrier, delivery availability information may specify one or more delivery periods during which that shipment carrier is available to deliver shipments of one or more items to designated locations. This delivery availability information may be utilized to generate a scheduled delivery tool that enables users to select a particular delivery period during which an item is to be delivered. The scheduled delivery tool may provide multiple selectable delivery periods based on the delivery availability information of multiple shipment carriers. The scheduled delivery component may determine that a particular delivery period has been selected and generate a delivery instruction based on such selection.

Abstract: A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may he chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing hone density, or for the treatment of various disorders in mammalian and avian species.

Abstract: A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.

Abstract: A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.

Abstract: A method generates optimized traffic movement plans. A plan monitor determines a first planning boundary for traffic based upon traffic conditions of a region. A plan generator employs the first planning boundary and repetitively generates first traffic movement plans for the traffic. The plan generator selects one of the first traffic movement plans as a first optimized traffic movement plan, and outputs the same for controlling traffic movement. The plan monitor determines current traffic conditions of the region for a planning window, and updates the first planning boundary to provide a second planning boundary for the traffic based upon the current traffic conditions. The plan generator employs the second planning boundary and repetitively generates second traffic movement plans for the traffic, selects one of the first and second traffic movement plans as a second optimized traffic movement plan, and outputs the same for controlling traffic movement.