Patents by Inventor Andrew Kuhn
Andrew Kuhn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9499858Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.Type: GrantFiled: January 11, 2013Date of Patent: November 22, 2016Assignee: Becton, Dickinson and CompanyInventors: James G. Nadeau, Tobin Hellyer, Dolores M. Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha-Sha Wang, Keith Edward Thornton
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Publication number: 20150152473Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.Type: ApplicationFiled: January 11, 2013Publication date: June 4, 2015Applicant: BECTON, DICKINSON AND COMPANYInventors: James G. Nadeau, Tobin Hellyer, Dolores M. Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha-Sha Wang, Keith Edward Thornton
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Patent number: 8708942Abstract: A custom ankle brace system is disclosed which is constructed from a low temperature non-olefinic elastomeric blend material, and methods of fabricating and fitting the same. This material can be molded directly to a custom mold made from a casting of an affected body part. The final product will be an ankle brace that is able to be heated at low temperature (150° F.-200° F.) by use of an oven or equivalent, and custom molded directly on the patient. If necessary reheated, the ankle brace may be remolded to account for a change in the patient's anatomy or for an increase in comfort.Type: GrantFiled: February 10, 2010Date of Patent: April 29, 2014Inventor: Jeffrey Andrew Kuhn
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Patent number: 8372605Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.Type: GrantFiled: March 25, 2011Date of Patent: February 12, 2013Assignee: Becton, Dickinson and CompanyInventors: James Nadeau, Tobin J. Hellyer, Dolores M. Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha-Sha Wang, Keith Edward Thornton
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Publication number: 20110244457Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.Type: ApplicationFiled: March 25, 2011Publication date: October 6, 2011Applicant: Becton, Dickinson and CompanyInventors: James Nadeau, Tobin Hellyer, Dolores M. Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha Sha Wang, Keith Thornton
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Publication number: 20110196276Abstract: A custom ankle brace system is disclosed which is constructed from a low temperature non-olefinic elastomeric blend material, and methods of fabricating and fitting the same. This material can be molded directly to a custom mold made from a casting of an affected body part. The final product will be an ankle brace that is able to be heated at low temperature (150° F.-200° F.) by use of an oven or equivalent, and custom molded directly on the patient. If necessary reheated, the ankle brace may be remolded to account for a change in the patient's anatomy or for an increase in comfort.Type: ApplicationFiled: February 10, 2010Publication date: August 11, 2011Inventor: Jeffrey Andrew Kuhn
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Patent number: 7932060Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte.Type: GrantFiled: April 19, 2004Date of Patent: April 26, 2011Assignee: Becton, Dickinson and CompanyInventors: James Nadeau, Tobin Hellyer, Dolores Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha Sha Wang, Keith Thornton
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Publication number: 20050009050Abstract: A high-sensitivity, low-background immuno-amplification assay is provided, which offers a streamlined workflow suitable for high-throughput assays of clinically relevant samples, such as blood and other bodily fluids. The assay comprises the use of two proximity members that each comprise an analyte-specific binding component conjugated to an oligonucleotide. Binding an analyte brings the oligonucleotide moieties of the proximity members in sufficiently close contact that the oligonucleotides form an amplicon. The presence of the analyte then is detected through amplification of the amplicon and detection of the amplified nucleic acids. The sensitivity of the assay of the present invention is improved by preventing spurious or non-specific amplicon formation by proximity members that are not complexed with an analyte. In one embodiment, target-independent amplicon formation is prevented by using hybridization blocker oligonucleotides that bind oligonucleotide moieties that are not hybridized to each other.Type: ApplicationFiled: April 19, 2004Publication date: January 13, 2005Inventors: James Nadeau, Tobin Hellyer, Dolores Berger, William Nussbaumer, Robert Rosenstein, Andrew Kuhn, Sha Wang, Keith Thornton