Patents by Inventor Andrew L. Frelinger, III

Andrew L. Frelinger, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR ANALYZING PLATELETS BY MASS CYTOMETRY
    Publication number: 20220128545
    Abstract: The invention provides methods of simultaneously detecting one or more biomarkers associated with one or more platelets in a platelet sample by contacting the sample with one or more metal-tagged probes or mixtures thereof; washing the sample to remove unbound probes; and analyzing the sample by mass cytometry to simultaneously detect binding of the one or more metal-tagged probes or mixtures thereof to one or more biomarkers associated with the one or more platelets. Compositions, panels and kits for use with the methods described herein are also provided.
    Type: Application
    Filed: July 3, 2019
    Publication date: April 28, 2022
    Applicant: Children's Medical Center Corporation
    Inventors: Thomas A. Blair, Alan D. Michelson, Andrew L. Frelinger, III
  • Methods, Systems, And Compositions For Determining Blood Clot Formation, And Uses Thereof
    Publication number: 20200292531
    Abstract: A method is directed to determining a thrombosis function and includes flowing a fluid sample over a surface having a fixed endothelial cell monolayer. The method further includes stimulating the fixed endothelial cell monolayer to induce formation of a clot, the clot being formed via interaction between the fixed endothelial cell monolayer and the fluid sample. In response to the clot formation, the method further includes determining a thrombosis function associated with the fluid sample and the fixed endothelial cell monolayer.
    Type: Application
    Filed: April 29, 2020
    Publication date: September 17, 2020
    Inventors: Donald E. Ingber, Abhishek Jain, Andries D. van der Meer, Alan David Michelson, Andrew L. Frelinger, III, Riccardo Barrile
  • Methods, systems, and compositions for determining blood clot formation, and uses thereof
    Patent number: 10732172
    Abstract: A method is directed to determining a thrombosis function and includes flowing a fluid sample over a surface having a fixed endothelial cell monolayer. The method further includes stimulating the fixed endothelial cell monolayer to induce formation of a clot, the clot being formed via interaction between the fixed endothelial cell monolayer and the fluid sample. In response to the clot formation, the method further includes determining a thrombosis function associated with the fluid sample and the fixed endothelial cell monolayer.
    Type: Grant
    Filed: May 22, 2016
    Date of Patent: August 4, 2020
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Donald E. Ingber, Abhishek Jain, Andries D. van der Meer, Alan David Michelson, Andrew L. Frelinger, III, Riccardo Barrile
  • Vitro methods for determining in vivo thrombotic events
    Patent number: 7122324
    Abstract: Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed.
    Type: Grant
    Filed: September 3, 2004
    Date of Patent: October 17, 2006
    Assignee: The Scripps Research Institute
    Inventors: Mark H. Ginsberg, Andrew L. Frelinger, III, Edward F. Plow
  • In vitro methods for determining in vivo thrombotic events
    Patent number: 6787320
    Abstract: Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: September 7, 2004
    Assignee: The Scripps Research Institute
    Inventors: Mark H. Ginsberg, Andrew L. Frelinger, III, Edward F. Plow
  • Test kits for detecting the presence of C-terminal hGPIIb fragments
    Patent number: 6323324
    Abstract: Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: November 27, 2001
    Assignee: The Scripps Research Institute
    Inventors: Mark H. Ginsberg, Andrew L. Frelinger, III, Edward F. Plow
  • In vitro methods for determining in vivo thrombotic events
    Patent number: 6063907
    Abstract: Antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: May 16, 2000
    Assignee: The Scripps Research Institute
    Inventors: Mark H. Ginsberg, Andrew L. Frelinger, III, Edward F. Plow
  • In vitro methods for determining in vivo thrombotic events
    Patent number: 5763580
    Abstract: Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of C-terminal hGPIIb fragment of the platelet receptor GPIIb-IIIa in a body fluid sample are disclosed.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: June 9, 1998
    Assignee: The Scripps Research Institute
    Inventors: Mark H. Ginsberg, Andrew L. Frelinger, III, Edward F. Plow
  • Antibodies that bind to a ligand-induced binding site on GPIIIa
    Patent number: 5470738
    Abstract: An antibody that immunoreacts with a ligand-induced binding site (LIBS) on GPIIIa, and particularly, a LIBS induced in a platelet-associated GPIIb-IIIa/fibrinogen complex is disclosed. Further disclosed are diagnostic systems and methods for assaying LIBS-containing platelets in a vascular fluid sample using the antibodies of the invention.
    Type: Grant
    Filed: October 4, 1993
    Date of Patent: November 28, 1995
    Assignee: The Scripps Research Institute
    Inventors: Andrew L. Frelinger, III, Edward F. Plow, Mark H. Ginsberg
  • Antibodies that bind to a ligand-induced binding site on integrin and induce integrin activation
    Patent number: 5306620
    Abstract: An integrin-activating antibody is disclosed that immunoreacts with an integrin and when immunoreacted increases the binding affinity of the integrin for binding to ligands specific for the integrin. The antibody also immunoreacts with a ligand-induced binding site (LIBS) on the integrin when the integrin is specifically bound to its ligand. Further disclosed are therapeutic compositions and methods for promoting cell adhesion using the disclosed integrin-activating antibodies.
    Type: Grant
    Filed: November 13, 1990
    Date of Patent: April 26, 1994
    Assignee: The Scripps Research Institute
    Inventors: Mark H. Ginsberg, Timothy E. O'Toole, Edward F. Plow, Andrew L. Frelinger, III
  • Antibodies that bind to a ligand-induced binding site on GPIIIa
    Patent number: 5284751
    Abstract: An antibody that immunoreacts with a ligand-induced binding site (LIBS) on GPIIIa, and particularly, a LIBS induced in a platelet-associated GPIIb-IIIa/fibrinogen complex is disclosed. Further disclosed are diagnostic systems and methods for assaying LIBS-containing platelets in a vascular fluid sample using the antibodies of the invention.
    Type: Grant
    Filed: October 5, 1989
    Date of Patent: February 8, 1994
    Assignee: The Scripps Research Institute
    Inventors: Andrew L. Frelinger, III, Edward F. Plow, Mark H. Ginsberg