Abstract: A vaporizer device includes various modular components. The vaporizer device includes a first subassembly. The first subassembly includes a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device includes a second subassembly. The second subassembly includes a skeleton defining a rigid tray that retains at least a power source. The vaporizer device also includes a third subassembly. The third subassembly includes a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.

Abstract: Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.

Abstract: Methods are provided herein for assembling at least two nucleic acids using a sequence specific nuclease agent (e.g., a gRNA-Cas complex) to create end sequences having complementarity and subsequently assembling the overlapping complementary sequences. The nuclease agent (e.g., a gRNA-Cas complex) can create double strand breaks in dsDNA in order to create overlapping end sequences or can create nicks on each strand to produce complementary overhanging end sequences. Assembly using the method described herein can assemble any nucleic acids having overlapping sequences or can use a joiner oligo to assemble sequences without complementary ends.

Abstract: A system includes a current source circuit; a system power input; and load switching circuitry coupling the current source circuit and the system power input to an output configured to couple to a vaporizer heating element. The current source circuit, the system power input, and the load switching circuitry form part of an integrated circuit. Related apparatus, systems, techniques, and articles are also described.

Abstract: A system includes a current source circuit; a system power input; and load switching circuitry coupling the current source circuit and the system power input to an output configured to couple to a vaporizer heating element. The current source circuit, the system power input, and the load switching circuitry form part of an integrated circuit. Related apparatus, systems, techniques, and articles are also described.

Abstract: A method for activating a vaporizer device may include a point-of-sale device receiving, based on an identifier of the vaporizer device, activation data associated with the vaporizer device. The vaporizer device may be activated by communicating, to the vaporizer device, the activation data. The point-of-sale device may communicate the activation data to the vaporizer device via a dock coupled with the vaporizer device. Moreover, the point-of-sale device may communicate the activation data to the vaporizer device through a packaging of the vaporizer device. Alternatively, the point-of-sale device may communicates the activation data to the vaporizer device by communicating the activation data to a computing device associated with a user of the vaporizer device. The computing device may further communicate the activation data to the vaporizer device via audio signals and/or optical signals corresponding to the activation data. Related systems and articles of manufacture are also provided.

Abstract: A vaporizer system may include a vaporizer device and a vaporizer accessory configured to couple to the vaporizer device. The vaporizer accessory may include a sensor configured to continuously and passively monitor a biomarker of the user. The biomarker includes a concentration of carbon monoxide in the user's blood. Related systems and methods are also described.

Abstract: A system includes a current source circuit; a system power input; and load switching circuitry coupling the current source circuit and the system power input to an output configured to couple to a vaporizer heating element. The current source circuit, the system power input, and the load switching circuitry form part of an integrated circuit. Related apparatus, systems, techniques, and articles are also described.

Abstract: A vaporizer device may include various modular components. The vaporizer device may include a first subassembly. The first subassembly may include a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device may include a second subassembly. The second subassembly may include a skeleton defining a rigid tray that retains at least a power source. The vaporizer device may also include a third subassembly. The third subassembly may include a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.

Abstract: A vaporizer device includes various modular components. The vaporizer device includes a first subassembly. The first subassembly includes a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device includes a second subassembly. The second subassembly includes a skeleton defining a rigid tray that retains at least a power source. The vaporizer device also includes a third subassembly. The third subassembly includes a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.

Abstract: A vaporizer system may include a vaporizer device communicatively coupled with a user device configured to control the functions and/or features of the vaporizer device. The vaporizer device may serve as a replacement for traditional combustible cigarettes. Accordingly, the user device may be configured to collect usage data from the vaporizer device and generate recommendations to enhance and/or expedite the transition from traditional combustible cigarettes to the vaporizer device. For example, the user device may provide puff coaching to enable a more satisfying initial experience. Alternatively and/or additionally, the user device may recommend pod types and/or puff patterns that are associated with a reduction in overall intake.

Abstract: A vaporizer device may include various modular components. The vaporizer device may include a first subassembly. The first subassembly may include a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device may include a second subassembly. The second subassembly may include a skeleton defining a rigid tray that retains at least a power source. The vaporizer device may also include a third subassembly. The third subassembly may include a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.