Patents by Inventor Andrew L. Roughton

Andrew L. Roughton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLIC PEPTIDES TARGETING ALPHA-4-BETA-7 INTEGRIN
    Publication number: 20210300932
    Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide.
    Type: Application
    Filed: March 26, 2021
    Publication date: September 30, 2021
    Inventors: Manuel Perez VAZQUEZ, M. Monzur MORSHED, Jennifer L. HICKEY, Adam Paul KAFAL, James GILLARD, Narendra PATEL, Sai Kumar CHAKKA, Andrew L. ROUGHTON, Marc-André POUPART, Gaoqiang YANG
  • Cyclic peptides targeting alpha-4-beta-7 integrin
    Patent number: 11072616
    Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: July 27, 2021
    Assignees: Universite de Montreal, Zealand Pharma A/S
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Adam Paul Kafal, James Gillard, Narendra Patel, Sai Kumar Chakka, Andrew L. Roughton, Marc-André Poupart, Gaoqiang Yang
  • Fragment synthesis of substituted cyclic peptides
    Patent number: 11046695
    Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: June 29, 2021
    Assignees: Zealand Pharma A/S, Universite de Montreal
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Marc-André Poupart, Gaoqiang Yang, James Gillard, Adam Paul Kafal, Andrew L. Roughton
  • Fragment synthesis of substituted cyclic peptides
    Patent number: 10981921
    Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: April 20, 2021
    Assignee: Zealand Pharma A/S
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Marc-André Poupart, Gaoqiang Yang, James Gillard, Adam Paul Kafal, Andrew L. Roughton
  • FRAGMENT SYNTHESIS OF CYCLIC PEPTIDES
    Publication number: 20200361944
    Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.
    Type: Application
    Filed: August 4, 2020
    Publication date: November 19, 2020
    Inventors: Manuel Perez VAZQUEZ, M. Monzur MORSHED, Jennifer L. HICKEY, Marc-André POUPART, Gaoqiang YANG, James GILLARD, Adam Paul KAFAL, Andrew L. ROUGHTON
  • Cyclic Peptides Targeting Alpha-4-Beta-7 Integrin
    Publication number: 20200165300
    Abstract: There is described herein antagonists of ?4?7 integrin, and more particularly to cyclic peptide antagonists. Accordingly, there is described herein a compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are various substituents; stereocentres 1*, 2* and 3* are each independently selected from R and S; n is 1, 2, 3, or 4 and where n is 2-4, Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide.
    Type: Application
    Filed: November 14, 2016
    Publication date: May 28, 2020
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Adam Paul Kafal, James Gillard, Narendra Patel, Sai Kumar Chakka, Andrew L. Roughton, Marc-André Poupart, Gaoqiang Yang
  • Fragment Synthesis of Cyclic Peptides
    Publication number: 20190077805
    Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.
    Type: Application
    Filed: November 14, 2016
    Publication date: March 14, 2019
    Inventors: Manuel Perez Vazquez, M. Monzur Morshed, Jennifer L. Hickey, Marc-André Poupart, Gaoqiang Yang, James Gillard, Adam Paul Kafal, Andrew L. Roughton
  • SOLID PHASE SYNTHESIS OF CYCLIC AMINO ACID MOLECULES
    Publication number: 20170320908
    Abstract: The present invention relates to cyclic amino acid molecules and methods of preparing the same, and in particular the macrocyclization of amino acids or linear peptides bound to a solid support.
    Type: Application
    Filed: November 17, 2015
    Publication date: November 9, 2017
    Inventors: Jennifer L. Hickey, John Mancuso, Eric Marsault, Andrew L. Roughton, Adam P. Treder, Marie-Claude J. Trembley, Andrei K. Yudin, Serge Zaretsky
  • ISOMERIC PURINONES AND 1H-IMIDAZOPYRIDINONES AS PKC-THETA INHIBITORS
    Publication number: 20090281075
    Abstract: A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC? inhibitors, and their methods of use are disclosed.
    Type: Application
    Filed: November 7, 2008
    Publication date: November 12, 2009
    Applicant: PHARMACOPEIA, INC.
    Inventors: Andrew L. Roughton, Yajing Rong, Koc-Kan Ho, Michael J. Ohlmeyer, David Diller, Ray Jui-Hsiang Chan, Gaifa Lai