Patents by Inventor Andrew L. Salzman

Andrew L. Salzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
    Patent number: 8609833
    Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: December 17, 2013
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Csaba Szabo, Andrew L. Salzman
  • PURINE DERIVATIVES AS ADENOSINE A1 RECEPTOR AGONISTS AND METHODS OF USE THEREOF
    Publication number: 20120264706
    Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.
    Type: Application
    Filed: April 20, 2012
    Publication date: October 18, 2012
    Applicant: INOTEK PHARMACEUTICALS CORPORATION
    Inventors: Prakash JAGTAP, Csaba SZABO, Andrew L. SALZMAN
  • Antibodies against flagellin and uses thereof
    Patent number: 8263078
    Abstract: The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: September 11, 2012
    Assignees: Inotek Pharmaceuticals Corporation, Yeda Research and Development Co., Ltd.
    Inventors: Nurit Rachamim, Andrew L. Salzman, Kanneganti Murthy
  • Purine derivatives as adenosine Areceptor agonists and methods of use thereof
    Patent number: 8183224
    Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: May 22, 2012
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Csaba Szabo, Andrew L. Salzman
  • Antibodies against flagellin and uses thereof
    Patent number: 8173130
    Abstract: The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: May 8, 2012
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Andrew L. Salzman, Kanneganti Murthy
  • Purine derivatives and methods of use thereof
    Patent number: 8133880
    Abstract: The invention relates to Purine Derivatives having the formula; The invention also relates to pharmaceutical compositions comprising an effective amount of the Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of the Purine Derivative to a subject in need thereof.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: March 13, 2012
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Andrew L. Salzman, Csaba Szabo
  • PURINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20110059915
    Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of a Purine Derivative to a subject in need thereof.
    Type: Application
    Filed: November 12, 2010
    Publication date: March 10, 2011
    Applicant: INOTEK PHARMACEUTICALS CORPORATION
    Inventors: Prakash JAGTAP, Andrew L. SALZMAN, Csaba SZABO
  • Purine Derivatives and methods of use thereof
    Patent number: 7863253
    Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological disorder, a skin disorder, a radiation-induced injury, a wound, or an inflammatory disease comprising administering an effective amount of a Purine Derivative to a subject in need thereof.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: January 4, 2011
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Andrew L. Salzman, Csaba Szabo
  • ANTIBODIES AGAINST FLAGELLIN AND USES THEREOF
    Publication number: 20100239583
    Abstract: The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating infections and diseases using anti-flagellin antibodies in humans, other animals and birds.
    Type: Application
    Filed: March 4, 2010
    Publication date: September 23, 2010
    Applicant: INOTEK PHARMACEUTICALS CORPORATION
    Inventors: Kanneganti MURTHY, Andrew L. SALZMAN
  • Purine derivatives and methods of use thereof
    Patent number: 7732424
    Abstract: The present invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's core body temperature, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ophthalmic condition, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: June 8, 2010
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Andrew L. Salzman
  • Antibodies against flagellin and uses thereof
    Publication number: 20090208506
    Abstract: The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.
    Type: Application
    Filed: September 5, 2008
    Publication date: August 20, 2009
    Applicants: Inotek Pharmaceuticals Corporation, Yeda Research and Development Co., Ltd.
    Inventors: Nurit Rachamim, Andrew L. Salzman, Kanneganti Murthy
  • Antibodies against flagellin and uses thereof
    Publication number: 20090191208
    Abstract: The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.
    Type: Application
    Filed: September 5, 2008
    Publication date: July 30, 2009
    Applicant: Inotek Pharmaceuticals Corporation
    Inventors: Andrew L. Salzman, Kanneganti Murthy
  • Purine derivatives as adenosine A1 receptor agonists and methods of use thereof
    Publication number: 20090062314
    Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.
    Type: Application
    Filed: August 4, 2008
    Publication date: March 5, 2009
    Applicant: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Csaba Szabo, Andrew L. Salzman
  • ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20080262016
    Abstract: The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
    Type: Application
    Filed: June 16, 2008
    Publication date: October 23, 2008
    Applicant: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Erkan Baloglu, John H. van Duzer, Csaba Szabo, Andrew L. Salzman, Aloka Roy, William Williams, Alexander Nivorozhkin
  • Purine Derivatives as adenosine Areceptor agonists and methods of use thereof
    Patent number: 7423144
    Abstract: The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's rate of metabolism, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: September 9, 2008
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Csaba Szabo, Andrew L. Salzman
  • Isoquinoline derivatives and methods of use thereof
    Patent number: 7268143
    Abstract: The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: September 11, 2007
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Csaba Szabo, Andrew L. Salzman, Aloka Roy, William Williams
  • Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
    Patent number: 6958324
    Abstract: Inosine compounds, compositions comprising an inosine compound and methods for treating or preventing an inflammation disease or a reperfusion disease comprising administering an effective amount of an inosine compound to a patient in need thereof are disclosed.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: October 25, 2005
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Andrew L. Salzman, Csaba Szabo
  • Isoquinoline derivatives and methods of use thereof
    Patent number: 6956035
    Abstract: The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: October 18, 2005
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Erkan Baloglu, John H. van Duzer, Csaba Szabo, Andrew L. Salzman
  • Substituted indeno[1,2-c]isoquinoline derivatives and methods of use thereof
    Patent number: 6828319
    Abstract: The invention provides novel classes of substituted Indeno[1,2-c]isoquinoline Compounds. Pharmaceutical compositions and methods of making and using the compounds, are also described.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: December 7, 2004
    Assignee: Inotek Pharmaceuticals Corporation
    Inventors: Prakash Jagtap, Erkan Baloglu, John H. van Duzer, Csaba Szabo, Andrew L. Salzman
  • Isoquinoline derivatives and methods of use thereof
    Publication number: 20040039009
    Abstract: The invention provides novel classes of Isoquinoline Derivatives. Pharmaceutical compositions and methods of making and using the compounds, are also described.
    Type: Application
    Filed: February 28, 2003
    Publication date: February 26, 2004
    Inventors: Prakash Jagtap, Erkan Baloglu, John H. van Duzer, Csaba Szabo, Andrew L. Salzman, Aloka Roy, William Williams, Alexander Nivoroshkin