Patents by Inventor Andrew L. Wolfe
Andrew L. Wolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9624491Abstract: The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present invention is directed to methods and compositions for diagnosing and treating cancer, particularly T-ALL, by modulating miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing response to treatment, in assays for isolating and selecting antagonists, and as compositions for the treatment and management of cancer. Methods and compositions are provided for treatment or alleviation of cancer, particularly T-ALL, with antagonists/antagomirs of miRNAs, particularly one or more of miR-19b, miR-20a, miR26, miR92, miR148 and miR223.Type: GrantFiled: February 28, 2011Date of Patent: April 18, 2017Assignees: Memorial Sloan Kettering Cancer Center, Universiteit Gent, Columbia UniversityInventors: Hans-Guido Wendel, Andrew L. Wolfe, Konstantinos John Mavrakis, Elisa Oricchio, Adolfo A. Ferrando, Kim De Keersmaecker, Teresa Palomero, Franki Speleman, Pieter Van Vlierberghe
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Patent number: 9143814Abstract: A video server adaptively selects an appropriate video encoding standard and an appropriate video encoding rate for encoding video content to be downloaded to one or more video client devices over a communication network. The video server adaptively selects the video encoding standard and the video encoding rate based upon factors such as the data transmission rate of the communication network, the processing speed of the video client device, or the type of the video content to be downloaded. Once the video encoding standard and the video encoding rate are selected, video content can be transcoded prior to downloading to one or more video client devices. During the download, the video content may be adaptively transrated, such as in response to a change in the data transmission rate of the communication network.Type: GrantFiled: June 29, 2009Date of Patent: September 22, 2015Assignee: The DIRECTV Group, Inc.Inventors: Andrew L. Wolfe, David Westerhoff
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Patent number: 8428438Abstract: A television has an encoder, a random access memory buffer, and a decoder in addition to components of a conventional television receiver. The encoder encodes television signals to a digital format and the random access memory buffer stores the encoded television signal in response to activation of a pause function. The random access memory buffer outputs the stored digital television signal and the decoder decodes the digital television signal output from the random access memory buffer in response to deactivation of the pause function.Type: GrantFiled: March 24, 2003Date of Patent: April 23, 2013Assignee: The DIRECTV Group, Inc.Inventors: Andrew L. Wolfe, Edward J. Brachocki, Stephen G. Maine, Christopher W. Chevalier, Christopher L. Porter
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Publication number: 20130064810Abstract: The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present invention is directed to methods and compositions for diagnosing and treating cancer, particularly T-ALL, by modulating miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing response to treatment, in assays for isolating and selecting antagists, and as compositions for the treatment and management of cancer. Methods and compositions are provided for treatment or alleviation of cancer, particularly T-ALL, with antagonists/antagomirs of miRNAs, particularly one or more of miR-19b, miR-20a, miR26, miR92, miR148 and miR223.Type: ApplicationFiled: February 28, 2011Publication date: March 14, 2013Inventors: Hans-Guido Wendel, Andrew L. Wolfe, Konstantinos John Mavrakis, Elisa Oricchio, Adolfo A. Ferrando, Kim De Keersmaecker, Teresa Palomero, Franki Speleman, Pieter Van Vlierberghe
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Publication number: 20090288129Abstract: A video server adaptively selects an appropriate video encoding standard and an appropriate video encoding rate for encoding video content to be downloaded to one or more video client devices over a communication network. The video server adaptively selects the video encoding standard and the video encoding rate based upon factors such as the data transmission rate of the communication network, the processing speed of the video client device, or the type of the video content to be downloaded. Once the video encoding standard and the video encoding rate are selected, video content can be transcoded prior to downloading to one or more video client devices. During the download, the video content may be adaptively transrated, such as in response to a change in the data transmission rate of the communication network.Type: ApplicationFiled: June 29, 2009Publication date: November 19, 2009Applicant: The DIRECTV Group, Inc.Inventors: Andrew L. Wolfe, David Westerhoff
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Patent number: 7555006Abstract: A video server adaptively selects an appropriate video encoding standard and an appropriate video encoding rate for encoding video content to be downloaded to one or more video client devices over a communication network. The video server adaptively selects the video encoding standard and the video encoding rate based upon factors such as the data transmission rate of the communication network, the processing speed of the video client device, or the type of the video content to be downloaded. Once the video encoding standard and the video encoding rate are selected, video content can be transcoded prior to downloading to one or more video client devices. During the download, the video content may be adaptively transrated, such as in response to a change in the data transmission rate of the communication network.Type: GrantFiled: September 13, 2004Date of Patent: June 30, 2009Assignee: The Directv Group, Inc.Inventors: Andrew L. Wolfe, David Westerhoff
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Publication number: 20040128692Abstract: A television has an encoder, a random access memory buffer, and a decoder in addition to components of a conventional television receiver. The encoder encodes television signals to a digital format and the random access memory buffer stores the encoded television signal in response to activation of a pause function. The random access memory buffer outputs the stored digital television signal and the decoder decodes the digital television signal output from the random access memory buffer in response to deactivation of the pause function.Type: ApplicationFiled: March 24, 2003Publication date: July 1, 2004Inventors: Andrew L. Wolfe, Edward J. Brachocki, Stephen G. Maine, Christopher W. Chevalier, Christopher L. Porter
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Patent number: 5736688Abstract: A contact input system with conductive segments made of a conductive ink and formed to follow a selected pattern that are located on a rectangular resistive surface. The conductive segments to the left of a T-shaped segment at the midpoint of each side are generally Z-shaped and those to the right of the midpoint are shaped like an inverted Z. The segments are disposed in a generally parabolic shape curving towards the center of the active surface area. The top bar of each segment overlaps at least a portion of the bottom bar of the adjacent conductive segment. The system thus has only two overlapping lines of conductive segments. The segments linearize electric fields in the resistive surface in order to provide greater accuracy in determining the location of a contact point on the surface.Type: GrantFiled: August 2, 1995Date of Patent: April 7, 1998Assignee: The Graphics Technology Company, Inc.Inventors: Gary L. Barrett, Andrew L. Wolfe
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Patent number: 5041701Abstract: An edge linearization device for linearizing the electric fields in a resistive surface is described. A plurality of electrodes are disposed on the perimeter of an area on a surface having a substantially uniform resistivity. The device utilizes the geometry of the spaces between adjacent conductive elements to provide resistive elements. At least one of the electrodes has an extension. The extension or extensions of the electrodes are progressively inwardly displaced into the area from the perimeter so that there is at least one center-most extension on a first portion of said perimeter and also on a second, opposing portion of said perimeter. In a preferred embodiment, the invention utilizes a surface with a substantially rectangular area having four sides and four corners. Disposed along the sides are a plurality of electrodes and corner electrodes and disposed in the corners of the surface are corner connectors. The use of T-shaped extensions of the electrodes on such a surface is also disclosed.Type: GrantFiled: March 15, 1988Date of Patent: August 20, 1991Assignee: Carroll Touch IncorporatedInventors: Andrew L. Wolfe, Gary L. Barrett