Abstract: Provided are virus-like particle vaccines for human metapneumovirus (hMPV) in which the ectodomain of hMPV F protein is linked to, and thereby displayed on, a symmetric protein-based virus-like particle. For example, the vaccine antigen may be a N-terminal fusion of the ectodomain of hMPV F protein to a protein having a multimerization domain for a one- or two-component virus-like particle, such as a two-component icosahedral virus-like particle. Further provided are vaccine compositions, methods of manufacturing, and methods of use, e.g., immunizing a subject to generate a protective immune response to hMPV.

Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the antibodies binding fragments thereof described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof.

Abstract: Secure authentication and delayed transaction processing for booking management systems is provided. Third-party services partner with booking management systems to aggregate and list offerings of the third-party services in a digestible display on a one-stop platform. A booking management system can manage the authentication of payment card information on behalf of any number of such third-party services. The booking management system can maintain and process authentication information associated with traveler payment cards, and provide virtual payment information to the third-party services for delayed transactions. The third-party services may later initiate the delayed transactions using the virtual payment information, without being required to perform authentication processing on the traveler payment card information maintained by the booking management system.

Abstract: Secure authentication and delayed transaction processing for booking management systems is provided. Third-party services partner with booking management systems to aggregate and list offerings of the third-party services in a digestible display on a one-stop platform. A booking management system can manage the authentication of payment card information on behalf of any number of such third-party services. The booking management system can maintain and process authentication information associated with traveler payment cards, and provide virtual payment information to the third-party services for delayed transactions. The third-party services may later initiate the delayed transactions using the virtual payment information, without being required to perform authentication processing on the traveler payment card information maintained by the booking management system.

Abstract: A method of generating a structural model architecture, comprising receiving an input causality map, including: a plurality of variables, one or more links providing an indication of influence between pairs of variables, wherein at least one link provides an indication of influence between an input variable and at least one other variable; and one or more constraints associated with one or more of the variables and/or links, and generating an architecture for a structural model based on the input causality map, the structural model configured to predict a value of an output variable based on a value of at least one other variable in the plurality of variables.

Abstract: An exercise roller includes an elongated bar having grip handles arranged at opposing axial ends of the elongated bar, a cylindrical core supported by the elongated bar between the grip handles, and a cover that surrounds the cylindrical core and is formed of a material having a repeating pattern.

Abstract: Disclosed is a system for executing a data access transaction. The system comprises a server arrangement, the server arrangement being communicably coupled with at least one requesting device and at least one responding device. The server arrangement is configured to receive from a requesting device and a responding device, a first data and a second data respectively, wherein the first data and the second data are encrypted and temporally defined.

Abstract: Disclosed is a system, method and computer program for executing a data access transaction. The system comprises a server arrangement, communicably coupled with a requesting device(s) and a responding device(s). The server arrangement is configured to receive from the requesting device and the responding device, first data and second data respectively, wherein the first data and the second data are encrypted. Further, metadata of the first data is received from the requesting device; and an encrypted association score is determined by comparing the first data and the second data, wherein the encrypted association score is based at least on a dynamic evaluation component, wherein the dynamic evaluation component includes a causality measure.

Abstract: Far-side inflatable airbag assemblies are disclosed to be installed to deploy adjacent an occupant during a far-side collision event or a far-side oblique collision event, and may retain the occupant at the occupant's vehicle occupant position to protect the occupant from collision with structures within the vehicle, as well as from collisions with other occupants of the vehicle. The far-side inflatable airbag assemblies of the present disclosure may be particularly beneficial when installed between vehicle occupant positions of the vehicle.

Abstract: Disclosed is a system for executing a data access transaction. The system comprises a server arrangement, the server arrangement being communicably coupled with at least one requesting device and at least one responding device. The server arrangement is configured to receive from a requesting device and a responding device, a first data and a second data respectively, wherein the first data and the second data are encrypted and temporally defined.

Abstract: An exercise roller includes an elongated bar having grip handles arranged at opposing axial ends of the elongated bar, a cylindrical core supported by the elongated bar between the grip handles, and a cover that surrounds the cylindrical core and is formed of a material having a repeating pattern.

Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the antibodies binding fragments thereof described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof.

Abstract: An exercise roller includes an elongated bar having grip handles arranged at opposing axial ends of the elongated bar, a cylindrical core supported by the elongated bar between the grip handles, and a cover that surrounds the cylindrical core and is formed of a material having a repeating pattern.

Abstract: A face mask assembly includes a mask pad configured to cover at least a portion of a face of a wearer and allows a passage of air therethrough to the wearer. In addition, the face mask assembly includes a frame connected to an elastic member configured to secure the mask pad to the face of the wearer.

Abstract: Mitigation of audible output of one or more components in a charging circuit. A charging circuit may include a mitigation controller operative to monitor a frequency of voltage at an input of a charging circuit. The frequency of the voltage at the input node may result in a mitigation condition associated with audible output of one or more components of the charging circuit. In response to detection of the mitigation condition, the mitigation controller may temporarily disable the supply of power from charging circuit to a system load to mitigate (e.g., potentially eliminate) audible output of the circuit. During a time in which the charging circuit is disabled from supplying power to the system load, a battery of the device may supply power to the system load.

Abstract: Far-side inflatable airbag assemblies are disclosed to be installed to deploy adjacent an occupant during a far-side collision event or a far-side oblique collision event, and may retain the occupant at the occupant's vehicle occupant position to protect the occupant from collision with structures within the vehicle, as well as from collisions with other occupants of the vehicle. The far-side inflatable airbag assemblies of the present disclosure may be particularly beneficial when installed between vehicle occupant positions of the vehicle.

Abstract: A method for increasing an amplitude of reciprocal axial extensions and contractions of a shock tool configured to induce axial oscillations in a drillstring during drilling operations includes (a) selecting the shock tool. The shock tool has a central axis and an axial length. The shock tool includes an outer housing, a mandrel telescopically disposed within the outer housing, and a first annular piston fixably coupled to the mandrel. The shock tool has a first amplitude of reciprocal axial extension and contraction at a pressure differential between a first fluid pressure in the outer housing and a second fluid pressure outside the outer housing. In addition, the method includes (b) fixably coupling a second annular piston to the mandrel of the shock tool and increasing the axial length of the shock tool after (a). The second annular piston is axially spaced from the first annular piston.

Abstract: Disclosed is a system for executing a data access transaction. The system comprises a server arrangement, the server arrangement being communicably coupled with at least one requesting device and at least one responding device. The server arrangement is configured to receive from a requesting device and a responding device, a first data and a second data respectively, wherein the first data and the second data are encrypted and temporally defined.

Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Embodiments of this invention relate to the binding fragments of antibodies described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof.

Abstract: Far-side inflatable airbag assemblies are disclosed to be installed to deploy adjacent an occupant during a far-side collision event or a far-side oblique collision event, and may retain the occupant at the occupant's vehicle occupant position to protect the occupant from collision with structures within the vehicle, as well as from collisions with other occupants of the vehicle. The far-side inflatable airbag assemblies of the present disclosure may be particularly beneficial when installed between vehicle occupant positions of the vehicle.