Patents by Inventor Andrew Lennard Lewis

Andrew Lennard Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10350295
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalized with radiopaque species.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: July 16, 2019
    Assignee: BIOCOMPATIBLES UK LTD.
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20190142946
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 16, 2019
    Inventors: Stephane HOHN, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20190111159
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers.
    Type: Application
    Filed: September 5, 2018
    Publication date: April 18, 2019
    Inventors: Stéphane HOHN, Andrew Lennard LEWIS, Sean Leo WILLIS, Matthew R. DREHER, Koorosh ASHRAFI, Yiqing TANG
  • Publication number: 20190070332
    Abstract: The present invention provides emulsion compositions comprising an continuous oil phase, a discontinuous aqueous phase and a plurality of microparticles. The composition may comprise a pharmaceutical active ingredient located in the oil phase, the particulate phase or the aqueous phase. The emulsion compositions have improved stability and coherence and are useful in the treatment of tumours by embolotherapy.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 7, 2019
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Matthew R. DREHER, Andrew Lennard LEWIS, Sean Leo WILLIS, Shui Ting CHUNG, Marcus Gordon CAINE
  • Patent number: 10098972
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: October 16, 2018
    Assignee: BIOCOMPATIBLES UK LTD.
    Inventors: Stéphane Hohn, Andrew Lennard Lewis
  • Publication number: 20180250230
    Abstract: New cationic polymers are provided that are suitable for the preparation of microspheres. The microspheres are capable of loading and eluting anionic species such as drugs and find use in i.a.
    Type: Application
    Filed: September 5, 2016
    Publication date: September 6, 2018
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Clare Louise HEAYSMAN, Andrew LLOYD, Gary James PHILLIPS, Andrew Lennard LEWIS
  • Publication number: 20180133236
    Abstract: A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
    Type: Application
    Filed: January 12, 2018
    Publication date: May 17, 2018
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard LEWIS, Peter William STRATFORD, Simon LEPPARD, Pedro GARCIA, Brenda HALL, Maria Victoria Fajardo GONZALEZ
  • Patent number: 9901590
    Abstract: A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: February 27, 2018
    Assignee: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard Lewis, Peter William Stratford, Simon Leppard, Pedro Garcia, Brenda Hall, Maria Victoria Fajardo Gonzalez
  • Patent number: 9895452
    Abstract: The present invention relates to hydrogels comprising 1,2-diol or 1,3-diol groups acetalized with a radiopaque species of one or more covalently bound radiopaque halogens which are imageable during embolization therapy. The invention further relates to methods of making radiopaque polymers and radiopaque hydrogel microspheres to provide an imageable drug delivery system.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: February 20, 2018
    Assignee: BIOCOMPATIBLES UK LIMITED
    Inventors: Stéphane Hohn, Andrew Lennard Lewis
  • Patent number: 9732142
    Abstract: The present invention concerns a composition comprising vesicles and encapsulated within the vesicles, an antibody, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block. Methods of delivering the above compositions into cells are also described.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: August 15, 2017
    Assignee: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard Lewis, Giuseppe Battaglia, Marzia Massignani
  • Publication number: 20160228556
    Abstract: Radiopaque hydrogels, in particular radiopaque hydrogel microspheres, comprising a polymer having 1,2-diol or 1,3-diol groups acetalised with radiopaque species.
    Type: Application
    Filed: September 5, 2014
    Publication date: August 11, 2016
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20160193367
    Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.
    Type: Application
    Filed: September 5, 2014
    Publication date: July 7, 2016
    Applicant: Biocompatibles UK LTD
    Inventors: Stéphane Hohn, Andrew Lennard Lewis, Sean Leo Willis, Matthew R. Dreher, Koorosh Ashrafi, Yiqing Tang
  • Publication number: 20160106673
    Abstract: The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block. Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
    Type: Application
    Filed: December 28, 2015
    Publication date: April 21, 2016
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard LEWIS, Giuseppe BATTAGLIA, Irene CANTON, Peter William STRATFORD
  • Publication number: 20160089445
    Abstract: The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula The polymers are particularly suitable for derivatising proteins, such as interferon-?.
    Type: Application
    Filed: August 6, 2015
    Publication date: March 31, 2016
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Stephen James BROCCHINI, Antony Robert GODWIN, Yiqing TANG, Andrew Lennard LEWIS
  • Publication number: 20160089389
    Abstract: A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
    Type: Application
    Filed: December 8, 2015
    Publication date: March 31, 2016
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard LEWIS, Peter William STRATFORD, Simon LEPPARD, Pedro GARCIA, Brenda HALL, Maria Victoria Fajardo GONZALEZ
  • Patent number: 9254258
    Abstract: The present invention provides a composition comprising vesicles and encapsulated within the vesicles, nucleic acid comprising less than 1000 nucleotides, wherein the vesicles comprise an amphiphilic block copolymer having a hydrophilic and a hydrophobic block. Methods of forming vesicles and methods of delivering nucleic acid, in particular, iRNA into cells, are also provided.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: February 9, 2016
    Assignee: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard Lewis, Giuseppe Battaglia, Irene Canton, Peter William Stratford
  • Patent number: 9241895
    Abstract: A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: January 26, 2016
    Assignee: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard Lewis, Peter William Stratford, Simon Leppard, Pedro Garcia, Brenda Hall, Maria Victoria Fajardo Gonzalez
  • Patent number: 9109016
    Abstract: The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula The polymers are particularly suitable for derivatising proteins, such as interferon-?.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: August 18, 2015
    Assignee: BIOCOMPATIBLES UK LIMITED
    Inventors: Stephen James Brocchini, Antony Robert Godwin, Yiqing Tang, Andrew Lennard Lewis
  • Publication number: 20150110722
    Abstract: The present invention relates to hydrogels comprising 1,2-diol or 1,3-diol groups acetalised with a radiopaque species of one or more covalently bound radiopaque halogens which are imageable during embolization therapy. The invention further relates to methods of making radiopaque polymers and radiopaque hydrogel microspheres to provide an imageable drug delivery system.
    Type: Application
    Filed: September 5, 2014
    Publication date: April 23, 2015
    Inventors: Stéphane HOHN, Andrew Lennard LEWIS, Sean Leo WILLIS, Matthew DREHER, Koorosh ASHRAFT, Yiqing TANG
  • Publication number: 20140162969
    Abstract: There is provided a new use of microspheres comprising a water-insoluble, water-swellable polymer which is anionically charged at pH7, and electrostatically associated with the polymer, in releasable form, a cationically charged chemotherapeutic agent, in the manufacture of a composition for use in the treatment of a brain tumour, wherein in the treatment the composition is introduced into the brain and the chemotherapeutic agent is released from the microspheres, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water. Compositions comprising the microspheres and methods for the treatment of brain tumours are also provided.
    Type: Application
    Filed: February 14, 2014
    Publication date: June 12, 2014
    Applicant: BIOCOMPATIBLES UK LIMITED
    Inventors: Andrew Lennard LEWIS, Yiqing TANG, Peter William STRATFORD