Abstract: The present invention provides systems and methods for enhanced treatment of depression and other neuropsychiatric disorders. The present invention personalizes neuromodulation treatment parameters based on their acute neurophysiological and behavioral effects in an individual patient to enhance clinical response to a course of repetitive Transcranial Magnetic Stimulation (rTMS) treatment and hasten time to recovery. The present invention assesses a range of stimulation parameters for their ability to produce specific acute effects on neurophysiologic function (specific pattern of change in resting-state EEG; current source density), and/or specific acute effects on the performance of specific cognitive tasks (increased reward sensitivity; diminished risk aversion; restored response bias deficiency) in an individual patient.

Abstract: The present invention provides methods for monitoring neuropsychiatric treatment of depression and other disorders. The methods monitor the progress of neuropsychiatric treatment by examining electrical oscillations in the brain as measured by quantitative electroencephalography (qEEG). The methods are useful in predicting and guiding the outcome of neuropsychiatric treatment.