Abstract: The invention provides a method of screening for a potential candidate for treating autism, epilepsy and/or intellectual disability in a subject in need comprising contacting a cell culture or an animal with the potential drug and detecting one or more of the following features: enhancing with the binding of apocalmodulin to the IQ domain of IQSEC2; reducing the production of ARF6-GTP; inhibiting the constitutive activation of guanine nucleotide exchange factor (GEF) IQSEC2; increasing the surface expression of AMPA receptors the brain or a cell; and/or increasing basal synaptic transmission in the brain or the cell. Further provided is a method of treating autism, epilepsy and/or intellectual disability in a subject in need by administering a drug capable of presenting one or more of the above identified features in the described cell and animal models.

Abstract: Examples described herein include systems and methods for providing network insights on a graphical user interface (“GUI”). The GUI can visualize network errors to help administrative or information technology users more quickly identify issues with an enterprise application. The enterprise application can report network request information to a server. Then the GUI can present visual overlays that compare error metrics between different time cycles of the application. The visual overlay can graphically display these errors on top of one another for immediate relative visualization. Additionally, a grouped list of host destinations can be simultaneously provided. The destination addresses can be abbreviated, and errors grouped accordingly in a manner that provides advantageous error visualization.

Abstract: Systems and methods are described for exposing user experience data to tenants. A server can receive application data from an application executing on multiple user devices. The server can receive a signed credential that links the application data to its corresponding user device and a tenant associated with the user device. The server can extract data for a tenant using an identifier in the signed credentials. The server can insert the extracted data into a graphical user interface that displays the application data for the tenant.

Abstract: In some examples, transaction data is received in relation to transactions performed by an application on a mobile device. The transactions include interactions between the mobile device and at least one server. The transaction data is aggregated for a time period according to different time increments. The transaction data for the time period is stored in a first table aggregated into time intervals according to a first time increment, and the transaction data for the time period is also stored in a second table aggregated into time intervals according to a second time increment. A user interface can be generated to include transaction information generated using the transaction data aggregated for the time period.

Abstract: Examples described herein include systems and methods for providing network insights on a graphical user interface (“GUI”). The GUI can visualize network errors to help administrative or information technology users more quickly identify issues with an enterprise application. The enterprise application can report network request information to a server. Then the GUI can present visual overlays that compare error metrics between different time cycles of the application. The visual overlay can graphically display these errors on top of one another for immediate relative visualization. Additionally, a grouped list of host destinations can be simultaneously provided. The destination addresses can be abbreviated, and errors grouped accordingly in a manner that provides advantageous error visualization.

Abstract: A system that allows developers to designate transactions for an application to track and monitor the performance of their applications on various mobile devices. In some embodiments, each transaction is composed of multiple interactions across several different screens that interact with different services or functions. The transactions of some embodiments overlap or are nested within each other, so that multiple transactions are monitored simultaneously. In some embodiments, each transaction is assigned a value, allowing a developer to prioritize troubleshooting in an application, as well as quantifying the costs of various issues in the application. In some embodiments, the system includes a transaction agent is installed on various devices that identifies and monitors transactions in the system and a transaction server that receives transaction data from the mobile devices and processes the data to allow a developer to monitor the performance of the application.

Abstract: Examples described herein include systems and methods for providing user flow insights on a graphical user interface (“GUI”) for application process implementations across a network. The GUI can visualize successful and unsuccessful implementations of processes of an enterprise application. This can help administrative users more quickly identify issues with the application, which can report user flow information to a server. The GUI can present a first visual overlay comparing successful and unsuccessful user flows over specified time periods. Groups of successful and unsuccessful user flows can be displayed on top of one another for immediate relative visualization. Additionally, user flows can be grouped according to application processes and summarized in a second visual overlay. The second visual overlay can represent all user flows for an application process and be accompanied by a table of user flow entries, which may be expanded to reveal discrete events defining individual user flows.

Abstract: Examples described herein include systems and methods for providing network insights on a graphical user interface (“GUI”). The GUI can visualize network errors to help administrative or information technology users more quickly identify issues with an enterprise application. The enterprise application can report network request information to a server. Then the GUI can present visual overlays that compare error metrics between different time cycles of the application. The visual overlay can graphically display these errors on top of one another for immediate relative visualization. Additionally, a grouped list of host destinations can be simultaneously provided. The destination addresses can be abbreviated, and errors grouped accordingly in a manner that provides advantageous error visualization.

Abstract: Examples described herein include systems and methods for providing network insights on a graphical user interface (“GUI”). The GUI can visualize network errors to help administrative or information technology users more quickly identify issues with an enterprise application. The enterprise application can report network request information to a server. Then the GUI can present visual overlays that compare error metrics between different time cycles of the application. The visual overlay can graphically display these errors on top of one another for immediate relative visualization. Additionally, a grouped list of host destinations can be simultaneously provided. The destination addresses can be abbreviated, and errors grouped accordingly in a manner that provides advantageous error visualization.

Abstract: Examples described herein include systems and methods for providing user flow insights on a graphical user interface (“GUI”) for application process implementations across a network. The GUI can visualize successful and unsuccessful implementations of processes of an enterprise application. This can help administrative users more quickly identify issues with the application, which can report user flow information to a server. The GUI can present a first visual overlay comparing successful and unsuccessful user flows over specified time periods. Groups of successful and unsuccessful user flows can be displayed on top of one another for immediate relative visualization. Additionally, user flows can be grouped according to application processes and summarized in a second visual overlay. The second visual overlay can represent all user flows for an application process and be accompanied by a table of user flow entries, which may be expanded to reveal discrete events defining individual user flows.

Abstract: The invention provides a method of screening for a potential candidate for treating autism, epilepsy and/or intellectual disability in a subject in need comprising contacting a cell culture or an animal with the potential drug and detecting one or more of the following features: enhancing with the binding of apocalmodulin to the IQ domain of IQSEC2; reducing the production of ARF6-GTP; inhibiting the constitutive activation of guanine nucleotide exchange factor (GEF) IQSEC2; increasing the surface expression of AMPA receptors the brain or a cell; and/or increasing basal synaptic transmission in the brain or the cell. Further provided is a method of treating autism, epilepsy and/or intellectual disability in a subject in need by administering a drug capable of presenting one or more of the above identified features in the described cell and animal models.

Abstract: Examples described herein include systems and methods for providing network insights on a graphical user interface (“GUI”). The GUI can visualize network errors to help administrative or information technology users more quickly identify issues with an enterprise application. The enterprise application can report network request information to a server. Then the GUI can present visual overlays that compare error metrics between different time cycles of the application. The visual overlay can graphically display these errors on top of one another for immediate relative visualization. Additionally, a grouped list of host destinations can be simultaneously provided. The destination addresses can be abbreviated, and errors grouped accordingly in a manner that provides advantageous error visualization.

Abstract: Examples described herein include systems and methods for providing network insights on a graphical user interface (“GUI”). The GUI can visualize network errors to help administrative or information technology users more quickly identify issues with an enterprise application. The enterprise application can report network request information to a server. Then the GUI can present visual overlays that compare error metrics between different time cycles of the application. The visual overlay can graphically display these errors on top of one another for immediate relative visualization. Additionally, a grouped list of host destinations can be simultaneously provided. The destination addresses can be abbreviated, and errors grouped accordingly in a manner that provides advantageous error visualization.

Abstract: Some embodiments provide a service monitor that operates on a number of different mobile devices to track and monitor services that an application is using. An application may depend on a number of services, such as network services to access various cloud services. The service monitor operates in conjunction with the application to gather data relating to the services and send the gathered data to an API server. The gathering of the data can occur in many mobile devices that are of different types, that are from various different vendors, and/or that operate on different mobile operating systems.

Abstract: Some embodiments provide a system that allows application developers to track and monitor crashes that are occurring with their applications on various mobile devices. In some embodiments, crash logs are received from the mobile devices. Hash codes are generated based on the crash logs. A report to summarize the crash logs is generated based on the hash codes.

Abstract: The present invention is directed to methods and compositions of treating cardiovascular disease or disorder in a subject in need thereof, comprising steps of determining and identifying the haptoglobin phenotype of the subject and thereby selecting the course of treatment with an agent capable of raising HDL.

Abstract: Some embodiments provide a service monitor that operates on a number of different mobile devices to track and monitor services that an application is using. The service monitor of some embodiments includes a service call wrapper to intercept a request made by the application to access the service and capture data relating to the service request. The service monitor then sends the captured data to a performance monitoring server in order to present, based on the captured data and other captured data from other mobile devices, a set of performance reports relating to the performance of the service as used by the same application across a number of mobile devices.

Abstract: Some embodiments provide application performance management tools with a service monitor that operates on a number of different mobile devices to track and monitor services that an application is using. In some embodiments, the service monitor stores a log relating to the use of the service each time the application uses the service. The application performance tool also includes an error monitor to detect an application error and report the application error to a performance monitoring server along with one or more logs relating to the use of the service when the error is detected. The performance monitoring server then provides an error report with the one or more logs to assist a developer in diagnosing the cause of the error with the application.

Abstract: The present invention provides antibodies that differentially react with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein, proteins, cells, viral particles, compositions, and kits comprising same. The invention also provides methods for determining a haptoglobin type of a subject and methods for testing a subject for susceptibility to diabetic complications.

Abstract: Some embodiments provide a system that allows application developers to track and monitor crashes that are occurring with their applications on various mobile devices. In some embodiments, the system includes an application programing interface (API) server that receives crash reports with raw crash data from the mobile devices and facilitates in assigning each crash report to one of several different crash processing servers. The crash processing server of some embodiments receives the raw crash data and translates obscure data in the raw crash data into a human or developer readable form.