Abstract: This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-? which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

Abstract: A computing resource service provider provides a certificate management service that allows customers of the computing resource service provider to create, distribute, manage, and revoke digital certificates issued by public and/or private certificate authorities. In an embodiment, customers may use the certificate management service to generate private certificate authority which can issue signed certificates to network entities within the customer enterprise. In an embodiment, the private certificate authority is hosted by the computing resource service provider, and the certificate management service automates the renewal and management of active certificates. In an embodiment, the certificate management service allows customer applications to create, renew, and revoke certificates issued by both private and public certificate authorities via an application programming interface.

Abstract: Techniques for managing certificate metrics are described. A method of managing certificate metrics can include adding certificate data associated with one or more certificates to a plurality of slots of a metric certificate data store, reading, by a metric publisher, the certificate data associated with a first slot of the metric certificate data store in response to an event, determining a metric associated with each certificate associated with a subset of the certificate data associated with the first slot of the metric certificate data store, and providing the metric associated with each certificate to a resource monitoring service.

Abstract: The present disclosure generally relates to systems and methods for the gradual application of a new digital certificate to a service endpoint or server, with repeated rollbacks to an old digital certificate, whereby the new certificate is applied to a service endpoint and automatically rolled back to the previous certificate after an amount of time. After a period that corresponds to a set amount of time minus the time the new certificate was applied to the endpoint, the process starts again, except with an increased period of time for the new certificate.

Abstract: Techniques for certificate authority (CA) selection are described. A certificate management service of a cloud provider network receives a first request to generate a certificate from an electronic device, the first request including an indication of an identity of a user and an identification of a domain name to associate with the certificate. A CA selection policy applicable to the first request is identified, the CA selection policy including a CA selection rule. A CA to generate the certificate is identified by evaluating the CA selection rule, the CA selection rule associates at least a portion of the domain name with the CA. A second request to generate the certificate is sent to the identified CA. The certificate or an identification of the certificate from the CA is returned to the electronic device.

Abstract: Techniques are described for enabling users of a certificate management service to create certificate issuance policies that can be applied to certificate issuance requests across both public and private certificate authorities (CAs) and other certificate-related services. According to embodiments described herein, a certificate issuance policy includes one or more certificate issuance rules to be applied to requests associated with one or more specified user accounts or roles for certificate-related resources (e.g., public certificates, private certificates, etc.). The application of a certificate issuance rule can be conditioned on a particular request context (e.g., based on a user account or role associated with a request, a type of certificate requested, a subject name identified in the request, etc.) and can specify a wide range of actions to be performed on requests matching a rule (e.g., allowing or denying a request, modifying one or more parameters of the request, etc.).

Abstract: A computer system detects that a digital certificate is set to expire within a threshold amount of time. In response to detecting that the digital certificate is set to expire, the computer system generates an update to cause a second computer system to perform operations to indicate an upcoming expiration of the digital certificate. The computer system provides the update to the second computer system to cause the second computer system to perform the operations.

Abstract: A computing resource service provider provides a certificate management service that allows customers of the computing resource service provider to create, distribute, manage, and revoke digital certificates issued by public and/or private certificate authorities. In an embodiment, when a new certificate is generated, a certificate template is used to apply various settings and policies for the new certificate. In various examples, templates may be used to establish default values, enforce required and optional values, place restrictions on one or more data fields, and enforce signature requirements. In some embodiments, the template establishes rules for rejecting certificate requests that don't conform to the template.

Abstract: Examples described herein include systems and methods for providing network insights on a graphical user interface (“GUI”). The GUI can visualize network errors to help administrative or information technology users more quickly identify issues with an enterprise application. The enterprise application can report network request information to a server. Then the GUI can present visual overlays that compare error metrics between different time cycles of the application. The visual overlay can graphically display these errors on top of one another for immediate relative visualization. Additionally, a grouped list of host destinations can be simultaneously provided. The destination addresses can be abbreviated, and errors grouped accordingly in a manner that provides advantageous error visualization.

Abstract: Systems and methods are described for exposing user experience data to tenants. A server can receive application data from an application executing on multiple user devices. The server can receive a signed credential that links the application data to its corresponding user device and a tenant associated with the user device. The server can extract data for a tenant using an identifier in the signed credentials. The server can insert the extracted data into a graphical user interface that displays the application data for the tenant.

Abstract: In an embodiment, a computing resource service provider provides a certificate management service that allows customers of the computing resource service provider to create, distribute, manage, and revoke digital certificates issued by private certificate authorities. In an embodiment, a private certificate authority hosted by the computing resource service provider is able to issue signed certificates to network entities within the customer enterprise. In an embodiment, the certificate management service provides a network-accessible application programming interface to the private certificate authority that allows applications to create and deploy private certificates programmatically. In an embodiment, the system provides the flexibility to create private certificates for applications that require custom certificate lifetimes or resource names.

Abstract: A set of consumers of a producer-consumer system includes a main consumer subset and a backstop consumer subset. A plurality of updates to message processing information are deployed to the set of consumers. Each update of the plurality of updates is first deployed to the backstop consumer sub-set and is subsequently deployed to the main consumer subset. The main consumer subset may obtain messages from producers and attempt to process the messages. By contrast, the backstop consumer subset may obtain messages only after a failed processing attempt by the main consumers. Upon obtaining a message, a main consumer may process the message successfully or may fail processing and provide the message for processing by a backstop consumer, which may be more up to date than the main consumer.

Abstract: In some examples, transaction data is received in relation to transactions performed by an application on a mobile device. The transactions include interactions between the mobile device and at least one server. The transaction data is aggregated for a time period according to different time increments. The transaction data for the time period is stored in a first table aggregated into time intervals according to a first time increment, and the transaction data for the time period is also stored in a second table aggregated into time intervals according to a second time increment. A user interface can be generated to include transaction information generated using the transaction data aggregated for the time period.

Abstract: Examples described herein include systems and methods for providing network insights on a graphical user interface (“GUI”). The GUI can visualize network errors to help administrative or information technology users more quickly identify issues with an enterprise application. The enterprise application can report network request information to a server. Then the GUI can present visual overlays that compare error metrics between different time cycles of the application. The visual overlay can graphically display these errors on top of one another for immediate relative visualization. Additionally, a grouped list of host destinations can be simultaneously provided. The destination addresses can be abbreviated, and errors grouped accordingly in a manner that provides advantageous error visualization.

Abstract: A system that allows developers to designate transactions for an application to track and monitor the performance of their applications on various mobile devices. In some embodiments, each transaction is composed of multiple interactions across several different screens that interact with different services or functions. The transactions of some embodiments overlap or are nested within each other, so that multiple transactions are monitored simultaneously. In some embodiments, each transaction is assigned a value, allowing a developer to prioritize troubleshooting in an application, as well as quantifying the costs of various issues in the application. In some embodiments, the system includes a transaction agent is installed on various devices that identifies and monitors transactions in the system and a transaction server that receives transaction data from the mobile devices and processes the data to allow a developer to monitor the performance of the application.

Abstract: Examples described herein include systems and methods for providing user flow insights on a graphical user interface (“GUI”) for application process implementations across a network. The GUI can visualize successful and unsuccessful implementations of processes of an enterprise application. This can help administrative users more quickly identify issues with the application, which can report user flow information to a server. The GUI can present a first visual overlay comparing successful and unsuccessful user flows over specified time periods. Groups of successful and unsuccessful user flows can be displayed on top of one another for immediate relative visualization. Additionally, user flows can be grouped according to application processes and summarized in a second visual overlay. The second visual overlay can represent all user flows for an application process and be accompanied by a table of user flow entries, which may be expanded to reveal discrete events defining individual user flows.

Abstract: Examples described herein include systems and methods for providing network insights on a graphical user interface (“GUI”). The GUI can visualize network errors to help administrative or information technology users more quickly identify issues with an enterprise application. The enterprise application can report network request information to a server. Then the GUI can present visual overlays that compare error metrics between different time cycles of the application. The visual overlay can graphically display these errors on top of one another for immediate relative visualization. Additionally, a grouped list of host destinations can be simultaneously provided. The destination addresses can be abbreviated, and errors grouped accordingly in a manner that provides advantageous error visualization.

Abstract: Examples described herein include systems and methods for providing network insights on a graphical user interface (“GUI”). The GUI can visualize network errors to help administrative or information technology users more quickly identify issues with an enterprise application. The enterprise application can report network request information to a server. Then the GUI can present visual overlays that compare error metrics between different time cycles of the application. The visual overlay can graphically display these errors on top of one another for immediate relative visualization. Additionally, a grouped list of host destinations can be simultaneously provided. The destination addresses can be abbreviated, and errors grouped accordingly in a manner that provides advantageous error visualization.

Abstract: Examples described herein include systems and methods for providing user flow insights on a graphical user interface (“GUI”) for application process implementations across a network. The GUI can visualize successful and unsuccessful implementations of processes of an enterprise application. This can help administrative users more quickly identify issues with the application, which can report user flow information to a server. The GUI can present a first visual overlay comparing successful and unsuccessful user flows over specified time periods. Groups of successful and unsuccessful user flows can be displayed on top of one another for immediate relative visualization. Additionally, user flows can be grouped according to application processes and summarized in a second visual overlay. The second visual overlay can represent all user flows for an application process and be accompanied by a table of user flow entries, which may be expanded to reveal discrete events defining individual user flows.

Abstract: Transplantable unions of living cells with electronic circuits and optical systems interfaced with body parts, will be used to test, measure, monitor, control, repair, replace, or assist the functionality of body parts. Ordinary human cells and stem cells are deposited upon, grown, attached to, united, and coupled with non-rejectable biocompatable electronic circuits, sensors, radio transceivers, optical, electro-optical, and/or computer systems that are designed to be adaptively coupled with the cells to form new transplantable unions. Cells are 3D-printed, deposited, dispensed, painted, sprayed, air-brushed, injected, squirted, spritzed, or delivered by other means upon circuits, or optical systems that are designed and prepared to adaptively couple with the cells.