Abstract: Antibodies comprising unpaired variable domains, e.g., heavy chain variable (VH) domains, for binding antigen. Antibody comprising two immunoglobulin (Ig) chains, wherein a first Ig chain comprises a variable domain and a constant domain, and a second Ig chain comprises a constant domain, wherein the second Ig chain lacks a variable domain, leaving the variable domain of the first Ig chain unpaired. The antibody may comprise two Ig heavy chains and two Ig light chains, each heavy chain comprising a VH domain and a constant region comprising a CH1 domain, and each light chain comprising a CL domain, wherein one or both light chains lack a VL domain, thereby leaving one or both VH domains unpaired. Non-human animals (e.g., mice) engineered to produce antibodies having unpaired VH domains, involving deletion of sequence coding for light chain variable (VL) domains. Use of unpaired VH domains to generate antigen-binding molecules.

Abstract: An optical safety beam method and system. A transmitter periodically sends bursts of light pulses with varying strengths. The receiver analyzes the received light pulses to automatically adjust its sensitivity and to detect when the light path is partially obstructed even when there are stray light pulse reflections that reach the receiver.

Abstract: A method and system for the ultrasonic non-destructive testing of joints in plastic pipes using A-scans. A hand-held ultrasonic transducer is used to perform an A-scan and a comparison made on a response from the interface region of the joint used to determine a quality of the joint. Levels of result can provide a binary output to give an indication of whether or not a defect is present in the joint. Comparison techniques are described. Tests for coupling efficiency and performance are described making the system useable by an unskilled technician. The system finds application in fault detection on electro-fusion welds in plastic pipe joints.

Abstract: A tool provides for the batch processing of assets that will be utilized across multiple ad sizes, allowing quickly and simultaneously reformatting assets into multiple standard online advertisement formats so as to save time and cost in generating an online advertising campaign. The tool may include high level commands to allow a user to simultaneously or individually adjust an asset for different renderings for an online advertising campaign. The tool may also allow a user to adjust multiple assets simultaneously for different renderings for an online advertising campaign.

Abstract: A network-accessible computer includes a network-communications interface, configured to receive health metrics of a user over a computer network. The network-accessible computer also includes a logic machine, which is configured to localize the user in a virtual space based on the health metrics, identify k nearest neighbors in the virtual space having k shortest Euclidean distances to the user, and generate a health insight comparing the user to the k nearest neighbors. The network-communications interface is further configured to send the health insight to a computing device associated with the user via the computer network.

Abstract: A tool provides for the batch processing of assets that will be utilized across multiple ad sizes, allowing quickly and simultaneously reformatting assets into multiple standard online advertisement formats so as to save time and cost in generating an online advertising campaign. The tool may include high level commands to allow a user to simultaneously or individually adjust an asset for different renderings for an online advertising campaign. The tool may also allow a user to adjust multiple assets simultaneously for different renderings for an online advertising campaign.

Abstract: A tool provides for the batch processing of multiple ad units, allowing quickly and simultaneously reformatting assets into multiple standard online advertisement formats and exporting the ad units to an ad server with scripting code so as to save time and cost in generating an online advertising campaign. The tool may also include high level commands to allow a user to simultaneously or individually adjust an ad unit for different renderings for an online advertising campaign.

Abstract: A method and system for the ultrasonic non-destructive testing of joints in plastic pipesusing A-scans. Ahand-held ultrasonic transducer is used to perform an A-scan and a comparison made on a response from the interface region of the jointused to determine a quality of the joint. Levels of result can providea binary outputto give an indicationof whether or not a defect is present in thejoint. Comparison techniques are described. Tests for coupling efficiency and performance are described making the system useable by an unskilled technician.The system finds application in fault detection on electro-fusion welds in plastic pipe joints.

Abstract: The system and method for providing a composite image corresponding to a textual message. The composite image is generated by receiving a text message, parsing out styling information, using predetermined size and spacing for combinations of typographical characters in combinations with a graphics editing routine which allows for the recognition and translation of text into a series of images which can then be presented to a viewer as a composite image.

Abstract: Embodiments discussed herein provide a passive monitoring system for use in a residential independent living framework. In some exemplary embodiments, the system may be used to alert a primary caregiver of a possible decline or change in an activity of daily living (“ADL”) of the monitored individual. The system may collect usage data associated with, for example, electrical devices at the living quarters of the monitored individual. The collected data may include data pairs of time samples and voltage data associated with one or more electrical devices that the monitored individual is expected to utilize. Applying various filters to the collected data, a possible decline or change in ADL of the monitored individual may be identified.

Abstract: A system is provided which includes a key memory storing a group of keys for use in decryption and a programmable memory configured to store a set of rules governing access to the key memory and a first engine for deriving a first key using a second key from the key group. The engine is configured to transmit a request for access to the second key from the key memory. The system further includes logic connected between the engine and the key memory and further connected to the programmable memory. The logic is configured to receive the request from the engine and to use the set of rules to control the access to the second key in the key memory. The programmable memory is writeable in situ to replace the set of rules with an alternative set of rules.

Abstract: A process for the production of a mono-olefin from a feedstock comprising a paraffinic hydrocabon which process comprises a) partially combusting at a pressure of at least (15) barg a mixture of the hydrocarbon feed and a molecular oxygen-containing gas in contact with a catalyst capable of supporting combustion beyond the normal fuel rich limit of flammability where they are reacted to form a product comprising one or more mono-olefin(s), carbon monoxide and hydrogen and b) recovering the one or more olefin(s).

Abstract: The present invention provides a process for the production of olefins by autothermal cracking of a liquid paraffinic hydrocarbon-containing feedstock in the presence of a molecular oxygen-containing gas, wherein said process comprises (a) providing a liquid paraffinic hydrocarbon-containing feedstock, (b) mixing said liquid paraffinic hydrocarbon-containing feedstock with a diluent comprising steam, said diluent being pre-heated to a temperature of at least 300° C., to produce a vaporised diluent liquid paraffinic hydrocarbon-containing feedstream comprising at least 20% by volume of steam, (c) subsequently mixing said vaporised diluted liquid paraffinic hydrocarbon-containing feedstream with a molecular oxygen-containing gas to produce a diluted mixed feedstream, (d) subsequently contacting said diluted mixed feedstream with a catalyst capable of supporting combustion beyond the normal fuel rich limit of flammability, to provide a hydrocarbon product stream comprising olefins.

Abstract: An electro-optic (EO) polymer that has a tunable index of refraction and are synthesized by the copolymerization a bisphenol monomer including a chromophoric structure and two diepoxy monomers. One diepoxy monomer includes at least one fluorine atom, and the second diepoxy monomer includes no fluorine atoms. The EO films are prepared by applying an electric field across the film as the film is heated to its glass transition temperature. The electric field is removed after cooling the film. The index of refraction of these nonlinear optical polymer materials is tuned between about 1.58 to about 1.66 (measured with light having a wavelength of about 1.3 microns).

Abstract: The present invention concerns compositions comprising a radiotherapeutic agent, or an agent which can be converted to a radiotherapeutic, and a tissue glue. The compositions of the present invention are particularly useful for providing local radiotherapy. The present invention also concerns methods of using the compositions of the invention, particularly for radiotherapy.

Abstract: A method predicting stroke evolution uses magnetic resonance diffusion and perfusion images obtained shortly after the onset of stroke symptoms to automatically estimate the eventual volume of dead cerebral tissue resulting from the stroke. The diffusion and perfusion images are processed to extract region(s) of interest presenting tissue at risk of infarction. A midplane algorithm is also used to calculate ratio and diffusion and perfusion measures for modelling infarct evolution. A parametric normal classifier algorithm is used to predict infarct growth using the calculated measures.

Abstract: A spent fuel reprocessing method including the steps of partitioning U and Pu(III) in a solvent by solvent extraction and subsequently polishing the solvent in a neptunium rejection operation for removing Np therefrom. The solvent obtained from the neptunium rejection operation (the polished solvent or NpA solvent product) is then recycled to a U/Pu partitioning operation. The method enables a reduction in solvent feed and solvent effluent volumes.

Abstract: A spent fuel reprocessing method includes at least the formation of an aqueous solution and at least one solvent extraction step. Formohydroxarmic acid is used to reduce any Np(VI) to Np(V) and/or to form a complex with Np(IV). As a result, substantially all the neptunium present is retained in the aqueous phase during solvent extraction.