Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3, R5, A, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, U, V, W, L and E have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: A system and method includes dividing content of an electronic document into components. A document type of the electronic document is identified by comparing a document score against a document type criterion, the document score being based on a combination of a component score of each of the components. A user interface provides an indication of the document type.

Abstract: A system and method includes dividing content of an electronic document into components. A document type of the electronic document is identified by comparing a document score against a document type criterion, the document score being based on a combination of a component score of each of the components. A user interface provides an indication of the document type.

Abstract: Benzimidazole compounds that increase the rate of SOS-mediated nucleotide exchange on Ras by binding to a functionally relevant, chemically tractable pocket on the SOS protein, as part of the Ras:SOS:Ras complex.

Abstract: A portable device having a temperature setting element is described. In some implementations, the portable device can include a cap including an integrated power source for supplying power; a housing including a storage for storing content; and a temperature-setting element including a temperature detection component for detecting the temperature of the content and a temperature-adjusting component for adjusting the temperature of the content. The temperature-setting element can include a core and one or more flanges protruding from the core. The temperature-setting element can receive power supplied by the integrated power source to perform the adjustment of the temperature of the content.

Abstract: A system and method includes dividing content of an electronic document into components. A document type of the electronic document is identified by comparing a document score against a document type criterion, the document score being based on a combination of a component score of each of the components. A user interface provides an indication of the document type.

Abstract: A system for testing a wireless access device having a plurality of radio modules is provided. The system includes a housing having an interior chamber. The interior chamber is adapted to receive a wireless access device. A plurality of probes are positioned for respective alignment with an antenna of a corresponding radio module of the wireless access device. The plurality of probes are adapted to receive radio signals from the wireless access device.

Abstract: A system for testing a wireless access device having a plurality of radio modules is provided. The system includes a housing having an interior chamber. The interior chamber is adapted to receive a wireless access device. A plurality of probes are positioned for respective alignment with an antenna of a corresponding radio module of the wireless access device. The plurality of probes are adapted to receive radio signals from the wireless access device.

Abstract: A system and method for obtaining and using namespace related information for presenting XML content. A namespace responsive application program determines one or more namespaces contained in an XML document and queries a namespace library to identify namespace related information, such as a solution related to the namespace. The identified namespace related information is retrieved and used for opening the XML document.

Abstract: A system and method for providing namespace related information. A namespace library operating in a computer provides a central source of namespace related information for handling XML documents. The namespace related information may be used by other computer application programs operating in the computer. The namespace related information provided by the namespace library is indexed by namespace. Many types of namespace related information may be associated with each namespace. The computer application programs may obtain namespace related information by querying the namespace library using a particular namespace.

Abstract: A fixed spool fishing reel having a winding shaft wheel which is rotatable about the winding shaft axis by operation of a handle on the winding shaft. The winding shaft wheel engages a rotor drive which rotates about a first axis which is generally transverse of the winding shaft axis and which drives a spool reciprocating worm shaft. The latter is rotatable about a second axis generally parallel to the said first axis, via reduction gearing. The reduction gearing rotates about a third axis generally parallel to the said first and second axes. The said first, second and third axes are all on the same side of the plane of the winding shaft wheel in such a way as to enable winding shaft attachment means to be provided on both sides of the winding shaft wheel, so that a winding handle may be attached selectively to either one or the other of the two sides of the reel.

Abstract: A method of modifying low frequency components of a digital audio signal having left and right channel signals, including the steps of: a) filtering the left and right channels signals using respective left and right high-pass filters to form left and right high-pass filtered signals; b) filtering the left and right channel signals using respective left and right band-pass filters to form left and right low frequency signals; c) modifying the amplitude of the left and right low frequency signals to give modified left and right low frequency signals whereby signals with amplitude a where 0<a<a1 are amplified by a first constant value C1, signals with amplitude a1?a<a2 are amplified proportional to 1/a, signals with amplitude a=2a are unchanged, signals with amplitude a2<a<a3 are attenuated proportional to 1/a, and signals with amplitude a=a3 are attenuated by a second constant value C2; and d) combining the modified band-pass filtered left and right signals with the respective left and right hig

Abstract: Adenovirus vectors replication specific for cells expressing ?-fetoprotein (AFP) and their methods of use are provided. By providing for a transcriptional initiating regulation dependent upon AFP expression, virus replication is restricted to target cells expressing AFP, particularly hepatocellular carcinoma cells. The adenovirus vectors can be used to detect and monitor samples for the presence of AFP-producing cells as well as to kill selectively malignant cells producing AFP.

Abstract: A system and method for obtaining and using namespace related information for presenting XML content. A namespace responsive application program determines one or more namespaces contained in an XML document and queries a namespace library to identify namespace related information, such as a solution related to the namespace. The identified namespace related information is retrieved and used for opening the XML document.

Abstract: A method of modifying low frequency components of a digital audio signal having left and right channel signals, including the steps of: a) filtering the left and right channels signals using respective left and right high-pass filters to form left and right high-pass filtered signals; b) filtering the left and right channel signals using respective left and right band-pass filters to form left and right low frequency signals; c) modifying the amplitude of the left and right low frequency signals to give modified left and right low frequency signals whereby signals with amplitude a where 0<a<a1 are amplified by a first constant value C1, signals with amplitude a1≦a<a2 are amplified proportional to 1/a, signals with amplitude a=2a are unchanged, signals with amplitude a2<a<a3 are attenuated proportional to 1/a, and signals with amplitude a=a3 are attenuated by a second constant value C2; and d) combining the modified band-pass filtered left and right signals with the respective l

Abstract: A method of audio signal processing for a loudspeaker located close to an ear in use, the method consisting of or including:- creating one or more derived signals from an original monophonic input signal, the derived signals being representative of the original signal being scattered by one or more bodies remote from said ear (excluding room boundary reflection or reverberation), combining the derived signal or signals with said input signal to form a combined signal, and feeding the combined signal to said loudspeaker, thereby providing cues for enabling the listener to perceive the source of the sound of the original monophonic input signal to be located remote from said ear.