Abstract: A contact lens having antioxidant properties is described as well as methods of manufacturing the same. The contact lens can be present in a sealed contact lens package. The seal contact lens package can include at least a) a plastic base member having a cavity; b) a contact lens packaging solution in the cavity; c) a sterile, unworn contact lens immersed in the contact lens packaging solution in the cavity; and d) a cover that forms a liquid-tight seal with the plastic base member. As an example, the unworn contact lens is a silicone hydrogel contact lens having present therein vitamin E. The vitamin E is non-releasable from the unworn contact lens and the contact lens packaging solution has less than 1 ppm of vitamin E present. The vitamin E is trapped, embedded, absorbed, or non-covalently attached in the unworn contact lens.

Abstract: A contact lens having antioxidant properties is described as well as methods of manufacturing the same. The contact lens can be present in a sealed contact lens package. The seal contact lens package can include at least a) a plastic base member having a cavity; b) a contact lens packaging solution in the cavity; c) a sterile, unworn contact lens immersed in the contact lens packaging solution in the cavity; and d) a cover that forms a liquid-tight seal with the plastic base member. As an example, the unworn contact lens is a silicone hydrogel contact lens having present therein vitamin E. The vitamin E is non-releasable from the unworn contact lens and the contact lens packaging solution has less than 1 ppm of vitamin E present. The vitamin E is trapped, embedded, absorbed, or non-covalently attached in the unworn contact lens.

Abstract: A contact lens having antioxidant properties is described as well as methods of manufacturing the same. The contact lens can be present in a sealed contact lens package. The seal contact lens package can include at least a) a plastic base member having a cavity; b) a contact lens packaging solution in the cavity; c) a sterile, unworn contact lens immersed in the contact lens packaging solution in the cavity; and d) a cover that forms a liquid-tight seal with the plastic base member. As an example, the unworn contact lens is a silicone hydrogel contact lens having present therein vitamin E. The vitamin E is non-releasable from the unworn contact lens and the contact lens packaging solution has less than 1 ppm of vitamin E present. The vitamin E is trapped, embedded, absorbed, or non-covalently attached in the unworn contact lens.

Abstract: A contact lens having antioxidant properties is described as well as methods of manufacturing the same. The contact lens can be present in a sealed contact lens package. The seal contact lens package can include at least a) a plastic base member having a cavity; b) a contact lens packaging solution in the cavity; c) a sterile, unworn contact lens immersed in the contact lens packaging solution in the cavity; and d) a cover that forms a liquid-tight seal with the plastic base member. As an example, the unworn contact lens is a silicone hydrogel contact lens having present therein vitamin E. The vitamin E is non-releasable from the unworn contact lens and the contact lens packaging solution has less than 1 ppm of vitamin E present. The vitamin E is trapped, embedded, absorbed, or non-covalently attached in the unworn contact lens.

Abstract: A case is provided for holding one or more contact lenses. The case is configured to receive an inner pod, and the case includes an upper part and a lower part. The upper part is structured to move relative to the lower part from an open configuration wherein the upper and lower parts are at least partially separated to a closed configuration wherein the upper and lower parts are together. The upper part is also structured to move relative to the lower part from a disengaged position to an engaged position wherein, in the disengaged position, the case is movable between the open and closed configurations and in the engaged position, the case is locked in the closed configuration.

Abstract: Silicone hydrogel contact lenses are packaged in a packaging solution including an ophthalmically-acceptable concentration of a surfactant to provide a contact lens having a lower coefficient of friction compared to a control lens that is not packaged in the surfactant. The surfactant is a poly(ethylene oxide) (PEO)-containing surfactant having a molecular weight of up to about 6,000 daltons, or is an alkyl aryl-containing surfactant, or is both an alkyl aryl and PEO-containing surfactant having a molecular weight of up to about 6,000 daltons. Methods of manufacturing silicone hydrogel contact lenses are also described.

Abstract: A case is provided for holding one or more contact lenses. The case is configured to receive an inner pod, and the case includes an upper part and a lower part. The upper part is structured to move relative to the lower part from an open configuration wherein the upper and lower parts are at least partially separated to a closed configuration wherein the upper and lower parts are together. The upper part is also structured to move relative to the lower part from a disengaged position to an engaged position wherein, in the disengaged position, the case is movable between the open and closed configurations and in the engaged position, the case is locked in the closed configuration.

Abstract: A case is provided for holding one or more contact lenses. The case is configured to receive an inner pod, and the case includes an upper part and a lower part. The upper part is structured to move relative to the lower part from an open configuration wherein the upper and lower parts are at least partially separated to a closed configuration wherein the upper and lower parts are together. The upper part is also structured to move relative to the lower part from a disengaged position to an engaged position wherein, in the disengaged position, the case is movable between the open and closed configurations and in the engaged position, the case is locked in the closed configuration.

Abstract: An injectable, nonaqueous suspension including at least one therapeutic agent suspended in a single component vehicle. The single component vehicle is a single amphiphilic material, such as a polyethoxylated castor oil or derivative thereof, a polyoxyethylene alkyl ether, a polyoxyethylene sorbitan fatty acid ester, a polyoxyethylene stearate, a block copolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide, a block copolymer of polypropylene oxide-polyethylene oxide-polypropylene oxide, a tetra-functional block copolymer of polyethylene oxide-polypropylene oxide, or a tetra-functional block copolymer of polypropylene oxide-polyethylene oxide. A dosage kit that includes the injectable, nonaqueous suspension and a method of administering the injectable, nonaqueous suspension are also disclosed.

Abstract: Silicone hydrogel contact lenses comprising an ionic component sustain release of beneficial cationic polymers.

Abstract: An injectable, nonaqueous suspension including at least one therapeutic agent suspended in a single component vehicle. The single component vehicle is a single amphiphilic material, such as a polyethoxylated castor oil or derivative thereof a polyoxyethylene alkyl ether, a polyoxyethylene sorbitan fatty acid ester, a polyoxyethylene stearate, a block copolymer of polyethylene oxide-polypropylene oxide-polyethylene oxide, a block copolymer of polypropylene oxide-polyethylene oxide-polypropylene oxide, a tetra-functional block copolymer of polyethylene oxide-polypropylene oxide, or a tetra-functional block copolymer of polypropylene oxide-polyethylene oxide. A dosage kit that includes the injectable, nonaqueous suspension and a method of administering the injectable, nonaqueous suspension are also disclosed.

Abstract: Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions from a stent so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue.

Abstract: Contact lenses comprising phosphorylcholine groups release beneficial polyionic or guanidinium-containing agents.

Abstract: Contact lenses comprising an ionic component are packaged with a beneficial cationic agent in a temperature-sensitive packaging solution and/or a low ionic strength packaging solution.

Abstract: Contact lenses comprising phosphorylcholine groups release beneficial polyionic or guanidinium-containing agents.

Abstract: A sealed contact lens package contains a sterile, unworn contact lens and a contact lens packaging solution comprising epsilon polylysine (?PLL). The ?PLL protects the contact lens from microbial contamination caused by handling the lens when it is removed from its package.

Abstract: Contact lenses comprising phosphorylcholine groups release beneficial polyionic or guanidinium-containing agents.

Abstract: Silicone hydrogel contact lenses comprising an ionic component sustain release of beneficial cationic polymers.

Abstract: Contact lenses comprising phosphorylcholine groups release beneficial polyionic or guanidinium-containing agents.

Abstract: Antimicrobial ophthalmic devices such as contact lenses, ocular inserts, ocular bandages, and intraocular lenses comprise a hydrogel and an antimicrobially-effective amount of epsilon polylysine non-covalently attached to the hydrogel.