Abstract: Compounds of formula 1: wherein R1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0–3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R2 is hydroxy, amino, or lower alkoxy; R3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl; R4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.

Abstract: Compounds of formula 1: ##STR1## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0-3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro;R.sub.2 is hydroxy, amino, or lower alkoxy;R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amnino-acyl;R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.

Abstract: The invention disclosed teaches an arrow straightening machine which includes a nock or head alignment bearing attachment which allows for correction of any eccentricity or misaligmnent between the nock or head and the arrow shaft. The method discloses adhesively bonding the nock or head to the arrow shaft using the attachment device to align while the adhesive is in the unset condition.

Abstract: Apparatus for applying a continuous embossing pattern to webs of material such as paper or the like and a method for producing an embossing surface. The apparatus includes rollers which receive a web or webs of such material therebetween and removable embossing plates secured to the surface of the rollers and having an embossing surface for embossing the webs. The rollers are constructed such that they have magnetic properties whereby the embossing plates which are comprised of magnetically attracted material can be held against the roller surface. The plates are positioned in closely adjacent relationship with respect to each other such that they provide a continuous embossing pattern around the surface of the roller. The plates and the rollers also include mutually engaging registering means which permit the plates to be accurately aligned with respect to the roller surface.