Patents by Inventor Andrew M. Clausen

Andrew M. Clausen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Continuous flow processes for making bicyclic compounds
    Patent number: 11339103
    Abstract: Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous process for making [1.1.1]propellane can be conducted under reaction conditions that advantageously minimize clogging of a continuous flow reactor. A continuous flow process can be used to make precursors of [1.1.1]propellane.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: May 24, 2022
    Assignee: RECURIUM IP HOLDINGS, LLC
    Inventors: Joseph Robert Pinchman, Kevin Duane Bunker, Matthew M. Bio, Christopher Breen, Andrew M. Clausen, Yuanqing Fang, Hui Li, Jillian W. Sheeran
  • CONTINUOUS FLOW PROCESSES FOR MAKING BICYCLIC COMPOUNDS
    Publication number: 20210061730
    Abstract: Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous process for making [1.1.1]propellane can be conducted under reaction conditions that advantageously minimize clogging of a continuous flow reactor. A continuous flow process can be used to make precursors of [1.1.1]propellane.
    Type: Application
    Filed: September 6, 2018
    Publication date: March 4, 2021
    Inventors: Joseph Robert Pinchman, Kevin Duane Bunker, Matthew M. Bio, Christopher Breen, Andrew M. Clausen, Yuanqing Fang, Hui Li, Jillian W. Sheeran
  • Process for the preparation of enantiomerically enriched beta amino acid derivatives
    Patent number: 7495123
    Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: February 24, 2009
    Assignees: Solvias AG, Merck & Co., Inc.
    Inventors: Yi Xiao, Yongkui Sun, Thorsten Rosner, Nelo R. Rivera, Shane W. Krska, Andrew M. Clausen, Joseph D. Armstrong, III, Felix Spindler, Christophe Malan