Patents by Inventor Andrew M. Creighton
Andrew M. Creighton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5583212Abstract: Nucleoside thiotriphosphates carrying .sup.32 P in the gamma-thiophosphate group, prepared by reaction between a nucleoside diphosphate and a .sup.32 P labelled thiophosphate salt, are used as thiophosphorylating agents for antibodies that bind to tumour-associated antigens. The labelled thiotriphosphates can be used to introduce a therapeutically useful .sup.32 P atom into an antibody that has been modified by the incorporation into its structure of a peptide region capable of acting as a substrate for a phosphokinase. The resulting labelled antibody can then be used for injection in anti-tumour therapy and has clinical advantages over the corresponding phosphorylated analogue.Type: GrantFiled: September 19, 1994Date of Patent: December 10, 1996Assignee: British Technology Group LimitedInventors: Brian M. J. Foxwell, Peter Parker, Andrew M. Creighton
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Patent number: 5459240Abstract: A method is provided for attaching .sup.32 P to a protein, normally an antibody, that will bind with and irradiate a tumor-associated structure leading to diagnostic benefit. The invention is based upon the introduction of a peptide region to the protein, which is capable of acting as a substrate for a phosphokinase utilizing .sup.32 P-.gamma.-ATP as a typical source of the radionuclide. The conjugation of the substrate molecule to the protein may be achieved by chemical methods or by genetic engineering techniques. Novel substrate peptides are disclosed.Type: GrantFiled: October 7, 1994Date of Patent: October 17, 1995Inventors: Brian M. J. Foxwell, Peter Parker, Andrew M. Creighton
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Patent number: 5438057Abstract: A compound of formula (II): ##STR1## in which R.sub.1 and R.sub.2 together form a methylene or ethylene bridging group and R.sub.3 is a hydrogen, an acyclic aliphatic hydrocarbon group having a maximum of six carbon atoms or a group CH.sub.2 R.sub.4 in which R.sub.4 is a C.sub.1-5 alkyl group substituted by a hydroxy group or by a C.sub.1-6 alkoxy group, or a salt thereof formed with a physiologically acceptable inorganic or organic acid, are of value for use in therapy, particularly as cardioprotective agents.Type: GrantFiled: April 23, 1993Date of Patent: August 1, 1995Assignee: British Technology Group LimitedInventor: Andrew M. Creighton
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Patent number: 5340557Abstract: .sup.32 P-Thiophosphates of the general formula: ##STR1## wherein n =1, 2 or 3 and each M, which may be the same or different, is H or a cation, are prepared by heating H.sub.3.sup.32 PO.sub.4 or a salt thereof with at least an equivalent amount of a thiophosphoryl halide and then treating the reaction product with an aqueous medium to hydrolyse the reaction product and form the .sup.32 P thiophosphate.Type: GrantFiled: August 25, 1993Date of Patent: August 23, 1994Assignee: British Technology Group LimitedInventors: Andrew M. Creighton, William A. Jeffery
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Patent number: 5278187Abstract: Compounds of formula (II) ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen, alkyl, alkenyl and alkynyl groups having up to a maximum of four carbon atoms and being unsubstituted, and alkyl, alkenyl and alkynyl groups having up to a maximum of three carbon atoms and being substituted by one, or in the case of fluoro by one or more, substituents but with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydrogen or methyl, or R.sub.1 and R.sub.2 together constitute an ethylene bridging group, and R.sub.3 is a group which under physiological conditions undergoes elimination with the formation of a 3,5-dioxopiperazinyl ring, with the further proviso that the compound is in the meso or erythro configuration when each of R.sub.1 and R.sub.2 is the same or different unsubstituted or substituted alkyl, alkenyl or alkynyl group, and salts thereof with a physiologically acceptable inorganic or organic acid, are of value as prodrugs, particularly for effecting cardioprotection.Type: GrantFiled: September 24, 1991Date of Patent: January 11, 1994Assignee: British Technology Group Ltd.Inventors: Andrew M. Creighton, William A. Jeffery
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Patent number: 5162372Abstract: Compounds of formula (II) ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen, alkyl, alkenyl and alkynyl groups having up to a maximum of four carbon atoms and being unsubstituted, and alkyl, alkenyl and alkynyl groups having up to a maximum of three carbon atoms and being substituted by one, or in the case of fluoro by one or more, substituents but with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydrogen or methyl, or R.sub.1 and R.sub.2 together constitute an ethylene bridging group, and R.sub.3 is a group which under physiological conditions undergoes elimination with the formation of a 3,5-dioxopiperazinyl ring, with the further proviso that the compound is in the meso or erythro configuration when each of R.sub.1 and R.sub.Type: GrantFiled: March 25, 1991Date of Patent: November 10, 1992Assignee: National Research Development CorporationInventors: Andrew M. Creighton, William A. Jeffery
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Patent number: 5149710Abstract: Compounds of formula (II) ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen, alkyl, alkenyl and alkynyl groups having up to a maximum of four carbon atoms and being unsubstituted, and alkyl, alkenyl and alkynyl groups having up to a maximum of three carbon atoms and being substituted by one, or in the case of fluoro by one or more, substituents but with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydrogen or methyl, or R.sub.1 and R.sub.2 together constitute an ethylene bridging group, and R.sub.3 is a group which under physiological conditions undergoes elimination with the formation of a 3,5-dioxopiperazinyl ring, with the further proviso that the compound is in the meso or erythro configuration when each of R.sub.1 and R.sub.2 is the same or different unsubstituted or substituted alkyl, alkenyl or alkynyl group, and salts thereof with a physiologically acceptable inorganic or organic acid, are of value as prodrugs, particularly in the therapy of psoriasis.Type: GrantFiled: October 17, 1990Date of Patent: September 22, 1992Assignee: National Research Development CorporationInventors: Andrew M. Creighton, William A. Jeffery
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Patent number: 4902714Abstract: Compounds of the formula (II) ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen, alkyl, alkenyl and alkynyl groups having up to a maximum of four carbon atoms and being unsubstituted, and alkyl, alkenyl and alkynyl groups having up to a maximum of three carbon atoms and being substituted by one, or in the case of fluoro by one or more, substitutents but with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydrogen or methyl, or R.sub.1 and R.sub.2 together constitute an ethylene bridging group, and R.sub.3 is a group which under physiological conditions undergoes elimination with the formation of a 3,5-dioxopiperazinyl ring, with the further proviso that the compound is in the meso or erythro configuration when each of R.sub.1 and R.sub.Type: GrantFiled: April 19, 1988Date of Patent: February 20, 1990Assignee: National Research Development CorporationInventors: Andrew M. Creighton, William A. Jeffery
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Patent number: 4755619Abstract: Compounds of formula (II) ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen, alkyl, alkenyl and alkynyl groups having up to a maximum of four carbon atoms and being unsubstituted, and alkyl, alkenyl and alkynyl groups having up to a maximum of three carbon atoms and being substituted by one, or in the case of fluoro by one or more, substitutents but with the proviso that when R.sub.1 is hydrogen then R.sub.2 is hydrogen or methyl, or R.sub.1 and R.sub.2 together constitute an ethylene bridging group, and R.sub.3 is a group which under physiological conditions undergoes elimination with the formation of a 3,5-dioxopiperazinyl ring, with the further proviso that the compound is in the meso or erythro configuration when each of R.sub.1 and R.sub.Type: GrantFiled: March 24, 1986Date of Patent: July 5, 1988Assignee: National Research Development CorporationInventors: Andrew M. Creighton, William A. Jeffery
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Patent number: 4275063Abstract: A pharmaceutical composition useful for aiding regression and palliation of sarcoma, lymphosarcoma and leukaemia in mammals comprises a therapeutically effective amount of a compound of formula ##STR1## wherein R.sub.1 and R.sub.2 are each separately selected from hydrogen and methyl or together represent an ethylene bridging group, with the proviso that when both of the groups R.sub.1 and R.sub.2 are methyl they are disposed in the meso configuration, or a non-toxic salt thereof with a physiologically acceptable inorganic or organic acid, in combination with a physiologically acceptable diluent or carrier.Type: GrantFiled: February 14, 1977Date of Patent: June 23, 1981Assignee: National Research Development CorporationInventor: Andrew M. Creighton