Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.

Abstract: A surgical hub for use with a surgical system in a surgical procedure performed in an operating room is disclosed. The surgical hub comprises a control circuit configured to generate a first image of a surgical site from a real-time imaging source, receive a second image of the surgical site from a non-real-time image source, align the first image and the second image, generate a representation of the surgical site based on the first image and the second image as aligned, display the representation on a display screen, receive a first user selection to overlay hidden structures on the representation, receive a second user selection to manipulate the representation, and adjust the representation based on the second user selection.

Abstract: A phase lock loop (PLL) circuit which includes an input for inputting an incoming signal which is to be tracked, a phase lock loop subcircuit, a phase state indicator subcircuit, and a synchronized blanking window generator. These elements create a phase lock loop circuit capable of producing a stable output which closely tracks the incoming signal, even when the incoming signal shifts in phase by 180 degrees. The phase state indicator subcircuit detects a phase reversal in the incoming signal and outputs a signal indication such. This indicating signal is used by the phase lock loop subcircuit to produce a stable reference signal tracking the incoming signal most of the time. However, during a short period of time between the inversion of the incoming signal and the output of the indicating signal by the phase state indicator subcircuit, the synchronized blanking window generator provides a signal to the phase lock loop subcircuit which is used to stabilize the reference signal.

Abstract: A device for indicating the phase of the a full-frequency alternating current (AC) magnetic field signal transmitting from the pointing device of a cordless digitizer and for determining if the phase of a half-frequency alternating current (AC) magnetic field signal transmitting from the pointing device is approximately the same or approximately inverted from an immediately preceding half-frequency signal from the pointing device. The indication of the phase of the full-frequency pointing device signal is used by the digitizer logic circuits to determine the location of the pointing device on the tablet's sensing surface. The information concerning the change in phase of the half-frequency signal is used by the digitizer logic circuits to decode the status of various pointing device buttons. If the phase in the induced half-frequency signal is unchanged from the last, this no-change condition represents one binary state. If the phase has changed, the condition represents the other binary state.