Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.

Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R7, and R8 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: A method of operating a fuel injector includes determining a fuel pressure and a total fuel mass MTF to be injected per combustion cycle, defining first and second pulse widths PW1 and PW2 corresponding to first and second commanded fuel masses CM1 and CM2 wherein CM1+CM2=MTF, actuating the injector for the first and second pulse widths, detecting an opening delay for the injector, and storing the opening delay. The method may further include increasing PW1 and decreasing PW2 by a predetermined amount, repeating selected steps until PW2 is less than or equal to a predetermined minimum pulse width, changing the fuel pressure by a predetermined pressure amount, cycling through selected steps until the fuel pressure reaches a predetermined target fuel pressure, and commanding the injector to open earlier than a normally commanded opening time by a lead time based on stored opening delay data.

Abstract: A vehicle propulsion system includes a first pump having an inlet for receiving fuel from a fuel reservoir and an outlet for providing pressurized fuel to a fuel feed line at a first pressure, a fuel feed line pressure sensor, a second pump having an inlet for receiving fuel from the fuel feed line and an outlet for providing pressurized fuel to an engine fuel rail at a second pressure, the second pressure being higher than the first pressure, a fuel temperature sensor, and a controller controlling the first pump to reduce the pressure of the fuel in the fuel feed line and determining whether the pressure of the fuel in the fuel feed line has reached a vaporization pressure of a component in the fuel.

Abstract: A vehicle propulsion system includes a first pump having an inlet for receiving fuel from a fuel reservoir and an outlet for providing pressurized fuel to a fuel feed line at a first pressure, a fuel feed line pressure sensor, a second pump having an inlet for receiving fuel from the fuel feed line and an outlet for providing pressurized fuel to an engine fuel rail at a second pressure, the second pressure being higher than the first pressure, a fuel temperature sensor, and a controller controlling the first pump to reduce the pressure of the fuel in the fuel feed line and determining whether the pressure of the fuel in the fuel feed line has reached a vaporization pressure of a component in the fuel.

Abstract: A fuel system for a vehicle propulsion system includes a fuel temperature determination module that determines a temperature of a fuel, a fuel pressure determination module that determines a pressure of the fuel, a prime determination module that determines whether the determined fuel temperature is above a vaporization temperature on a predetermined distillation curve and the fuel pressure is below the predetermined distillation curve at the determined fuel temperature, and a controller programmed to command operation of a fuel pump in response to the prime determination module determining that the determined fuel temperature is above a vaporization temperature on the predetermined distillation curve and the fuel pressure is below the predetermined distillation curve at the determined fuel temperature.

Abstract: A gasoline Reid vapor pressure (RVP) detection system includes a fuel pump and a motor operating the fuel pump in a forward direction of rotation to feed a gasoline fuel to a vehicle engine. A control device is in communication with the motor selectively directing change from the forward direction of rotation to a reverse direction of rotation opposite to the forward direction of rotation. A pressure reduction device receives flow of the fuel during operation in the reverse direction of rotation and reduces a pressure of the fuel until fuel vaporization occurs. A pump speed at which vaporization of the fuel occurs at the pressure reduction device when a motor speed and a motor current change non-linearly is correlated to a fuel RVP.