Patents by Inventor Andrew MacAdam

Andrew MacAdam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Poliovaccine
    Patent number: 11938180
    Abstract: The invention provides poliovirus like particles, which comprise stabilised empty poliovirus capsids that retain their native antigenic properties. The invention also provides methods of identifying mutations useful in the production of such poliovirus like particles, methods of producing such poliovirus like particles and the use of such poliovirus like particles in methods of vaccinating against poliovirus.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: March 26, 2024
    Assignee: SECRETARY OF STATE FOR HEALTH AND SOCIAL CARE, MINISTERIAL CORRESPONDENCE AND PUBLIC ENQUIRIES, DEPARTMENT OF HEALTH AND SOCIAL CARE
    Inventor: Andrew Macadam
  • POLIOVACCINE
    Publication number: 20190358315
    Abstract: The invention provides poliovirus like particles, which comprise stabilised empty poliovirus capsids that retain their native antigenic properties. The invention also provides methods of identifying mutations useful in the production of such poliovirus like particles, methods of producing such poliovirus like particles and the use of such poliovirus like particles in methods of vaccinating against poliovirus.
    Type: Application
    Filed: January 17, 2018
    Publication date: November 28, 2019
    Inventor: Andrew Macadam
  • Vaccination method employing genetically stable attenuated polioviruses comprising multiple mutations in domain V of the 5? noncoding region
    Patent number: 9408903
    Abstract: The invention provides an attenuated poliovirus which does not have a base pair mismatch in stem (a) or (b) of domain V of the 5? non-coding region of its genome, wherein at least seven of the base pairs in stems (a) and (b) are U-A or A-U base pairs.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: August 9, 2016
    Assignee: The Secretary of State for Health
    Inventor: Andrew MacAdam
  • Inactivated poliovaccine
    Patent number: 9402892
    Abstract: The invention provides an attenuated polio virus having a 5? non-coding region consisting of the 5? non-coding region of Sabin 3, modified so that it does not have a base pair mismatch in stem (a) or (b) of domain V, wherein seven or eight of the base pairs in stems (a) and (b) are U-A or A-U base pairs; and a capsid protein from the Sabin 1, Mahoney, MEF or Saukett strain.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: August 2, 2016
    Assignee: The Secretary of State for Health
    Inventor: Andrew MacAdam
  • ATTENUATED POLIOVIRUSES
    Publication number: 20140112952
    Abstract: The invention provides an attenuated poliovirus which does not have a base pair mismatch in stem (a) or (b) of domain V of the 5? non-coding region of its genome, wherein at least seven of the base pairs in stems (a) and (b) are U-A or A-U base pairs.
    Type: Application
    Filed: October 14, 2013
    Publication date: April 24, 2014
    Applicant: THE SECRETARY OF STATE FOR HEALTH
    Inventor: Andrew MacAdam
  • INACTIVATED POLIOVACCINE
    Publication number: 20130344108
    Abstract: The invention provides an attenuated polio virus having a 5? non-coding region consisting of the 5? non-coding region of Sabin 3, modified so that it does not have a base pair mismatch in stem (a) or (b) of domain V, wherein seven or eight of the base pairs in stems (a) and (b) are U-A or A-U base pairs; and a capsid protein from the Sabin 1, Mahoney, MEF or Saukett strain.
    Type: Application
    Filed: December 29, 2011
    Publication date: December 26, 2013
    Applicant: THE SECRETARY OF STATE FOR HEALTH
    Inventor: Andrew MacAdam
  • Genetically stable attenuated polioviruses comprising multiple mutations in domain V of the 5? noncoding region
    Patent number: 8557252
    Abstract: The invention provides an attenuated poliovirus which does not have a base pair mismatch in stem (a) or (b) of domain V of the 5? non-coding region of its genome, wherein at least seven of the base pairs in stems (a) and (b) are U-A or A-U base pairs.
    Type: Grant
    Filed: August 10, 2007
    Date of Patent: October 15, 2013
    Assignee: The Secretary of State for Health
    Inventor: Andrew MacAdam
  • ATTENUATED POLIO VIRUSES
    Publication number: 20100158945
    Abstract: The invention provides an attenuated poliovirus which does not have a base pair mismatch in stem (a) or (b) of domain V of the 5? non-coding region of its genome, wherein at least seven of the base pairs in stems (a) and (b) are U-A or A-U base pairs.
    Type: Application
    Filed: August 10, 2007
    Publication date: June 24, 2010
    Inventor: Andrew MacAdam