Patents by Inventor Andrew Madin

Andrew Madin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic sulfamides for inhibition of gamma-secretase
    Patent number: 7427621
    Abstract: Compounds of formula I: inhibit the processing of AP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: September 23, 2008
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian James Collins, Joanne Clare Hannam, Timothy Harrison, Andrew Madin, Mark Peter Ridgill
  • Alkenyl-substituted spirocyclic sulfamides as inhibitors of gamma-secretase
    Patent number: 7371771
    Abstract: Compounds of formula (I) are disclosed: wherein R4 is an alkenyl group of defined structure. The compounds inhibit gamma-secretase, and hence are useful for treatment of Alzheimer's disease.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: May 13, 2008
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Jose Luis Castro Pineiro, Joanne Claire Hannam, Timothy Harrison, Andrew Madin, Mark Peter Ridgill
  • Sulphonamido-substituted bridged bicycloalkyl derivatives
    Patent number: 7365196
    Abstract: A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: April 29, 2008
    Assignees: Merck Sharp & Dohme Ltd., Merck Frosst Canada & Co.
    Inventors: Patrice Charles Belanger, Ian James Collins, Joanne Claire Hannam, Timothy Harrison, Stephen John Lewis, Andrew Madin, Edward Giles McIver, Alan John Nadin, Joseph George Neduvelil, Mark Steven Shearman, Adrian Leonard Smith, Timothy Jason Sparey, Graeme Irvine Stevenson, Martin Richard Teall
  • Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
    Publication number: 20080070895
    Abstract: Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: September 7, 2007
    Publication date: March 20, 2008
    Inventors: Ian Collins, Laura Cooper, Timothy Harrison, Linda Keown, Andrew Madin, Mark Ridgill
  • Piperidines and Related Compounds for Treatment of Alzheimer's Disease
    Publication number: 20080021043
    Abstract: Compounds of formula I: selectively inhibit production of A?(1-42) and hence are useful in treatment or prevention of disease associated with deposition of ?-amyloid in the brain.
    Type: Application
    Filed: October 20, 2005
    Publication date: January 24, 2008
    Applicant: MERCK SHARP & DOHME LTD.
    Inventors: Joanne Hannam, Janusz Kulagowski, Andrew Madin, Mark Ridgill, Eileen Seward
  • Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
    Patent number: 7282513
    Abstract: Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: October 16, 2007
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian James Collins, Laura Catherine Cooper, Timothy Harrison, Linda Elizabeth Keown, Andrew Madin, Mark Peter Ridgill
  • Sulphonamides for control of beta-amyloid production
    Patent number: 7205434
    Abstract: There is disclosed a novel class of sulphonamido-substituted bridged bicycloalkyl derivatives comprising a substitute on the bridgehead position. The compounds modulate the production of the ?-amyloid precursor protein, and hence are useful in the treatment of Alzheimer's Disease.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: April 17, 2007
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Joanne Clare Hannam, Timothy Harrison, Andrew Madin, Timothy Jason Sparey
  • Gamma-secretase inhibitors
    Publication number: 20060293373
    Abstract: Compounds of formula I: are potent inhibitors of gamma-secretase and hence find use in treatment or prevention of diseases associated with deposition of ?-amyloid.
    Type: Application
    Filed: September 16, 2004
    Publication date: December 28, 2006
    Applicant: MERCK SHARP & DOHME LIMITED
    Inventors: Ian Collins, Joanne Hannam, Andrew Madin, Mark Ridgill
  • Sulfonamides, sulfamates and sulfamides as gamma-secretase inhibitors
    Patent number: 7144910
    Abstract: Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: December 5, 2006
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Andrew Madin, Mark Peter Ridgill
  • Sulfamides as gamma-secretase inhibitors
    Patent number: 7138400
    Abstract: Novel sulfamides of formula (I) are disclosed. The compounds exert an inhibitory action on the processing of APP by gamma-secretase, and are therefore useful in the treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: November 21, 2006
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Ian James Collins, Joanne Claire Hannam, Timothy Harrison, Stephen John Lewis, Andrew Madin, Timothy Jason Sparey, Brian John Williams
  • Benzodiazepine derivatives as APP modulators
    Patent number: 7105509
    Abstract: A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: September 12, 2006
    Assignee: Merck Sharp & Dohme Limited
    Inventors: Jose Luis Castro Pineiro, Ian Churcher, Alexander Richard Guiblin, Timothy Harrison, Sonia Kerrard, Andrew Madin, Alan John Nadin, Andrew Pate Owens, Timothy Jason Sparey, Martin Richard Teall, Susannah Williams
  • Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
    Publication number: 20060173054
    Abstract: Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: March 2, 2006
    Publication date: August 3, 2006
    Inventors: Ian Collins, Laura Cooper, Timothy Harrison, Linda Keown, Andrew Madin, Mark Ridgill
  • Cyclic sulfamides for inhibiton of gamma-secretase
    Publication number: 20060135570
    Abstract: Compounds of formula I: inhibit the processing of AP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: October 31, 2003
    Publication date: June 22, 2006
    Inventors: Ian Collins, Joanne Hannam, Timothy Harrison, Andrew Madin, Mark Ridgill
  • Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase
    Patent number: 7041689
    Abstract: Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: May 9, 2006
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Ian James Collins, Laura Catherine Cooper, Timothy Harrison, Linda Elizabeth Keown, Andrew Madin, Mark Peter Ridgill
  • Sulfonamides, sulfamates and sulfamides as gamma-secretase inhibitors
    Publication number: 20060069147
    Abstract: Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
    Type: Application
    Filed: October 29, 2003
    Publication date: March 30, 2006
    Inventors: Andrew Madin, Mark Rdigill
  • Imidazolophthalazine derivatives as ligands for GABAA receptors
    Patent number: 6949549
    Abstract: A class of substituted imidazolo[5,1-a]phthalazine derivatives as ligands for GABAA receptors of formula I which are partial or full inverse agonists of an ?5 receptor subunit while being relatively free of activity at ?1 and/or ?2 and/or ?3 receptor subunit binding sites are described herein; they are therefore of benefit as a medicament for enhancing cognition but with the reduction or elimination of proconvulsant activity.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: September 27, 2005
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: Richard Alexander Jelley, Tamara Ladduwahetty, Angus Murray MacLeod, Andrew Madin, Francine Sternfeld
  • Alkenyl-substituted spirocyclic sulfamides as inhibitors of gamma-secretase
    Publication number: 20050182111
    Abstract: Compounds of formula (I) are disclosed: wherein R4 is an alkenyl group of defined structure. The compounds inhibit gamma-secretase, and hence are useful for treatment of Alzheimer's disease.
    Type: Application
    Filed: April 24, 2003
    Publication date: August 18, 2005
    Inventors: Jose Pineiro, Joanne Hannam, Timothy Harrison, Andrew Madin, Mark Ridgill
  • Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase
    Publication number: 20050182109
    Abstract: Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: April 24, 2003
    Publication date: August 18, 2005
    Inventors: Ian Collins, Laura Cooper, Timothy Harrison, Linda Keown, Andrew Madin, Mark Ridgill
  • Triazolo-pyridazine derivatives as ligands for GABA receptors
    Patent number: 6828322
    Abstract: A class of substituted 1,2,4-triazolo[4,3-b]pyridazine derivatives, possessing a fluoro-substituted phenyl ring at the 3-position and a heteroaryl-methoxy moiety at the 6-position, are selective ligands for GABAA receptors, in particular having high affinity for the &agr;2 and/or &agr;3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: December 7, 2004
    Assignee: Merck Sharp & Dohme Ltd.
    Inventors: William Robert Carling, Jose Luis Castro Pineiro, Ian James Collins, Alexander Richard Guiblin, Timothy Harrison, Andrew Madin, Kevin William Moore, Michael Geoffrey Russell, Gayle Scott, Leslie Joseph Street
  • Sulphonamides for control of beta-amyloid production
    Publication number: 20040186147
    Abstract: There is disclosed a novel class of sulphonamido-substituted bridged bicycloalkyl derivatives comprising a substitute on the bridgehead position. The compounds modulate the production of the &bgr;-amyloid precursor protein, and hence are useful in the treatment of Alzheimer's Disease.
    Type: Application
    Filed: January 20, 2004
    Publication date: September 23, 2004
    Inventors: Jonne Clare Hannam, Timothy Harrison, Andrew Madin, Timothy Jason Sparey