Abstract: Systems and methods are provided for implementing a multi-service file system for a hosted computing instance via a locally-addressable secure compute layer. Software within the instance can submit file operations to the secure compute layer, which the secure compute layer can translate into calls to one or more network-accessible storage services. To provide a multi-service file system, the secure compute layer can obtain mapping data mapping file system objects within the virtualized file system to different network-accessible storage services. On receiving a file operation, the secure compute layer can determine one or more network-accessible storage services corresponding to the file operation, and submit appropriate calls to the one or more network-accessible storage services.

Abstract: Particulate ?-glucan is solubilized at elevated pressure and temperature to form soluble ?-glucan. The method is safe and economical and produces a product that is an improved pharmaceutical agent.

Abstract: Particulate ?-glucan is solubilized at elevated pressure and temperature to form soluble ?-glucan. The method is safe and economical and produces a product that is an improved pharmaceutical agent.

Abstract: Particulate ?-glucan is solubilized at elevated pressure and temperature to form soluble ?-glucan. The method is safe and economical and produces a product that is an improved pharmaceutical agent.

Abstract: Modified and/or derivativized ?-glucans with an enhanced capacity to modulate human immune response as compared to the parent, unmodified and/or underivatized ?-glucans are demonstrated.

Abstract: Particulate ?-glucan is solubilized at elevated pressure and temperature to form soluble ?-glucan. The method is safe and economical and produces a product that is an improved pharmaceutical agent.

Abstract: The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.

Abstract: The invention is based on the discovery that certain small molecules can bind to the ATP binding site of D-Ala-D-Ala ligase, even in the absence of the enzyme's substrate, and can cause a conformational change in the enzyme structure similar to that which occurs upon binding of ATP and substrate to the enzyme. Without wishing to be bound by any theory, it is believed that such a conformational change is required for either activation or inhibition of the enzyme. The information obtained from this discovery has enabled identification of key interactions in the active site of the enzyme, as well as the design and opimization of inhibitors.

Abstract: The invention relates to a class of compounds that reacts with and neutralizes a reactive oxygen species, such as a free oxygen radical, in a patient and which can then be regenerated back to their original reactive chemical form by a naturally occurring enzyme in said patient. These compounds are useful to treat diseases in a patient characterized by a reactive oxygen species. Moreover, because these compounds can be regenerated back to their original, reactive chemical state in vivo, a single molecule can neutralize multiple molecules of the reactive species. This allows for the use of lower dosages for the treatment of disease, as compared to compounds presently used to treat that same disease, thus avoiding side effects associated with higher dosages.