Patents by Inventor Andrew Mamoru Kawasaki

Andrew Mamoru Kawasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2'-Modified Oligonucleotides
    Publication number: 20090198047
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2?-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
    Type: Application
    Filed: June 15, 2007
    Publication date: August 6, 2009
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew Mamoru Kawasaki
  • Sugar modified oligonucleotides
    Patent number: 7138517
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2?-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: November 21, 2006
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew Mamoru Kawasaki
  • Di-nitrogen heterocycle compositions
    Patent number: 6660466
    Abstract: Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: December 9, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Pei-Pei Kung, Andrew Mamoru Kawasaki
  • 2' -modified oligonucleotides
    Publication number: 20030187240
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
    Type: Application
    Filed: January 28, 2003
    Publication date: October 2, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew Mamoru Kawasaki
  • Compositions and methods for modulating RNA
    Patent number: 6610663
    Abstract: Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: August 26, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Thomas Bruice, Charles John Guinosso, Andrew Mamoru Kawasaki, Richard Griffey
  • 2'modified oligonucleotides
    Patent number: 6531584
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: March 11, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew Mamoru Kawasaki
  • Sugar modified oligonucleotides
    Publication number: 20030004325
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
    Type: Application
    Filed: November 28, 2001
    Publication date: January 2, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew Mamoru Kawasaki
  • Compositions and methods for modulating RNA
    Publication number: 20020160972
    Abstract: Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
    Type: Application
    Filed: October 10, 2001
    Publication date: October 31, 2002
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Thomas Bruice, Charles John Guinosso, Andrew Mamoru Kawasaki, Richard Griffey
  • Compositions and methods for modulating RNA
    Patent number: 6358931
    Abstract: Compositions and methods for modulating the activity of RNA are disclosed, In accordance with preferred embodiments, antisense compositions are prepared targeting reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: March 19, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Thomas Bruice, Charles John Guinosso, Andrew Mamoru Kawasaki, Richard Griffey
  • Aminooxy-modified oligonucleotide synthetic intermediates
    Patent number: 6194598
    Abstract: Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligonucleotide is modified to include an aminooxy moiety.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: February 27, 2001
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Muthiah Manoharan, Andrew Mamoru Kawasaki
  • 2'-O-aminooxy-modified oligonucleotides
    Patent number: 6127533
    Abstract: Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligonucleotide is modified to include an aminooxy moiety.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: October 3, 2000
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Muthiah Manoharan, Andrew Mamoru Kawasaki
  • 2'-modified oligonucleotides
    Patent number: 6005087
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
    Type: Grant
    Filed: March 5, 1998
    Date of Patent: December 21, 1999
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew Mamoru Kawasaki
  • 2'-O-modified oligonucleotides
    Patent number: 5872232
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 16, 1999
    Assignee: Isis Pharmaceuticals Inc.
    Inventors: Phillip Dan Cook, Andrew Mamoru Kawasaki
  • 2'-modified oligonucleotides
    Patent number: 5859221
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 12, 1999
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Andrew Mamoru Kawasaki