Abstract: The present disclosure relates to an injection device for expelling of a number of preset or user-selectable doses of a medicament, the injection device comprising: —an elongated housing (10; 310; 410) extending along a longitudinal axis (1), —an expelling mechanism (2) comprising a trigger (70) and a piston rod (30), —a dose setting mechanism (3) comprising a rotatable member (260; 360; 460; 560) and a counterpart member (240; 340; 440; 540), wherein the counterpart member and the rotatable member comprise a first mechanical code (242; 342; 442; 542) and a second mechanical code (262; 362; 462; 562), respectively, —wherein for setting of a dose the rotatable member (260; 360; 460; 560) is rotatable relative to the housing (10; 310; 410) and relative to the counterpart member (240; 340; 440; 40) within a range of numerous rotational states, and wherein during setting of the dose the rotatable member (260; 360; 460; 560) is constrained along the longitudinal axis (1) relative to the housing (10; 310; 410) or r

Abstract: A system and method for permuting known and unknown message bits before encoding to provide a beneficial rearrangement of bits. Such a method can improve distance properties in the resulting subcode. In various embodiments, the structure of a beneficial rearrangement is dependent on the parameters of how known and unknown bits are grouped and on the specific type of code being used. Given these two parameters, the message bits can be rearranged to more efficiently leverage any apriori knowledge.

Abstract: A method of negotiation of media between a source communication device and a destination communication device for multiplexing multiple media types on an IP transport address comprises the source communication device generating an offer message comprising an extension to the ICE protocol according to RFC 5245 to specify the IP transport address whereon the multiple media types can be multiplexed, wherein the offer message comprising the extension indicates support for both the multiplexing and a non-multiplexing of the multiple media types, and sending the offer message from the source communication device to the destination communication device.

Abstract: Electronic design automation systems, methods, and media are presented for clock gate placement with data path awareness. One embodiment involves accessing a circuit design with a clock tree, clock gates, and an initial movement area. A set of positions for a set of data path connection points associated with the data routing lines are identified, along with an expansion direction from the initial placement position toward the set of positions for the set of data path connection points, and the initial movement is expanded to consider additional placement options for the clock gate based on the data path connection points.

Abstract: The disclosure relates to modification of a heat resistant cytoplasmic heat stable 6-phosphogluconate dehydrogenase (6PGDH) enzyme by fusing the cytoplasmic 6PGDH enzyme in frame to a plastid-targeting sequence. This modification allows the import of the cytoplasmic 6PGDH enzyme into plastids of a plant cell. Polynucleotides encoding and expressing the modified cytoplasmic 6PGDH enzymes are provided. The disclosure further provides transgenic plants and seeds containing the disclosed polynucleotides and expressing the modified cytoplasmic 6PGDH enzymes during development. The invention further relates to methods for developing a transgenic plant that has increased heat resistance and yield during heat stress.

Abstract: Provided, in part, are compounds of Formula I pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: Provided, in part, are compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

Abstract: Various embodiments include providing a MTJ-based LUT and adding a system that short circuits or causes dielectric layer breakdown of selected MTJ junctions to permanently finalize a desired logic state configuration of selected MTJs that is read out by the LUT. Additional embodiments disable dielectric layer breakdown or short circuit control circuits to prevent further alterations to MTJ that have not had their dielectric layers broken down or shorted out. A control system then alters reading out the MTJ-based LUT to sense original higher and lower resistance values of un-shorted/altered MTJs as a higher resistance state and a shorted or dielectric layer that has been broken down as a lower resistance state. This combines the flexibility of a multiple-time programmable LUT-based FPGA with the security and reliability of a one-time programmable LUT-based FPGA which has characteristics of a fixed logic non-programmable integrated circuit or application specific integrated circuit (ASIC).

Abstract: Technology for dynamically altering video content is provided. In one example, the technology may involve receiving a request for video content of a content sharing service; retrieving the video content based on the request for video content; determining geographical data for a user device being served the video content; determining, by a processor, an audio preference for the visitor based on the determined geographical data; retrieving, by the processor, audio from a data store comprising multiple audio items based on the determined audio preference, wherein the audio corresponds to the determined geographical data for the user device; augmenting the video content by replacing audio of the video content with the retrieved audio in the video content; and communicating the video content to the user device.

Abstract: A system for removing and donning a disposable absorbent article by using a separate robotic device includes an absorbent assembly having an inner layer that partly defines a body-facing surface, an outer layer that defines a garment-facing surface, and an absorbent body disposed between the inner and outer layers. The absorbent assembly also includes a pair of ears extending transversely outward from the opposite sides of the absorbent assembly in the back waist region, each of the ears including a body-facing surface with a primary first fastening-component that is selectively engageable with a primary second fastening-component in the front waist region of the absorbent assembly in a wear configuration of the article, and a garment-facing surface opposite the body-facing surface. The absorbent article also includes a manipulation-enablement feature configured to assist the post-retail manipulation of the absorbent article by the robotic device.

Abstract: A synthetic diamond material comprises a surface, wherein the surface comprises a first surface region comprising a first concentration of quantum spin defects. A second surface region has a predetermined area and is located adjacent to the first surface region, the second region comprising a second concentration of quantum spin defects. The first concentration of quantum spin defects is at least ten times greater than the second concentration of quantum spin defects, and at least one of the first or second surface regions comprises chemical vapour deposition, CVD, synthetic diamond. A method of producing the synthetic diamond material is also disclosed.

Abstract: Methods for producing in a plant a complex transgenic trait locus comprising at least two altered target sequences in a genomic region of interest are disclosed. The methods involve the use of two or more double-strand-break-inducing agents, each of which can cause a double-strand break in a target sequence in the genomic region of interest which results in an alteration in the target sequence. Also disclosed are complex transgenic trait loci in plants. A complex transgenic trait locus comprises at least two altered target sequences that are genetically linked to a polynucleotide of interest. Plants, plant cells, plant parts, and seeds comprising one or more complex transgenic trait loci are also disclosed.

Abstract: Compositions and methods for modulating male fertility in a plant are provided. Compositions comprise nucleotide sequences, and active fragments and variants thereof, which modulate male fertility. Further provided are expression cassettes comprising the male fertility polynucleotides, or active fragments or variants thereof, operably linked to a promoter, wherein expression of the polynucleotides modulates the male fertility of a plant. Various methods are provided wherein the level and/or activity of the sequences that influence male fertility is modulated in a plant or plant part. In certain embodiments, the plant is polyploid.

Abstract: The present invention relates to a process for cracking a hydrocarbon feedstock in a steam cracker unit, comprising the following steps of: feeding a liquid hydrocarbon feedstock to a hydrocracking unit, separating the stream thus hydrocracked in said hydrocracking unit into a high content aromatics stream and a gaseous stream comprising C2-C4 paraffins, hydrogen and methane, separating C2-C4 paraffins from said gaseous stream, feeding said C2-C4 paraffins thus separated to the furnace section of a steam cracker unit.

Abstract: A method of negotiation of media between a source communication device and a destination communication device for multiplexing multiple media types on an IP transport address comprises the source communication device generating an offer message comprising an extension to the ICE protocol according to RFC 5245 to specify the IP transport address whereon the multiple media types can be multiplexed, wherein the offer message comprising the extension indicates support for both the multiplexing and a non-multiplexing of the multiple media types, and sending the offer message from the source communication device to the destination communication device.

Abstract: Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell, for genome editing of a nucleotide sequence in the genome of a plant or plant cell, and/or for inserting or deleting a polynucleotide of interest into or from the genome of a plant. The methods and compositions employ a guide polynucleotide/Cpf1 endonuclease system to provide an effective system for modifying or altering target sequences within the genome of a plant, plant cell or seed. Also provided are guide polynucleotides/Cpf1 endonucleases complexes, guide polynucleotides, plant-optimized Cpf1 endonuclease sequences, recombinant DNA constructs comprising plant-optimized Cpf1 endonucleases genes, and combinations thereof.

Abstract: A tensioning bar assembly for a tensioning assembly of a drive system of an agricultural machine includes a longitudinal bar having a top end, a bottom end, and a threaded portion. An attachment device is coupled to the top end to attach to a tensioning arm. A compression spring is located around a portion of the longitudinal bar. A first spring retainer engages with and retains a first end of the spring. A first locking nut fits to the threaded portion of the bar and retains the first spring retainer longitudinally in place relative to the bar. The longitudinal bar is rotationally freely coupled to the attachment device to permit free axial rotation of the bar about its longitudinal axis relative to the attachment device, and an engagement head is attached to and located at or proximate the bottom end of the longitudinal bar for engagement with a tool.