Abstract: A method may include applying a protein sequence computation model to generate, based on an input protein sequence, a plurality of proposed protein sequences. A set of possible amino acid residues for each position in at least a portion of an output protein sequence may be identified based on the plurality of proposed protein sequences. A first protein structure having the output protein sequence may be generated by applying a protein structure computation model to select, for each position in at least the portion of the output protein sequence, an amino acid residue from a corresponding set of possible amino acid residues. The protein structure computation model may further determine the conformation of the amino acid residues selected for inclusion in the output protein sequence. In some cases, the first protein structure may be grafted onto a second protein structure to form a third protein structure.

Abstract: A monitoring feature, such as, for example, a pen cap, for an insulin delivery device may include at least one circuit adapted to detect at least one of a capping or decapping of the pen cap from an insulin pen and a processor for using information to the at least one of a capping or decapping of the pen cap. A monitoring feature for an insulin delivery device includes at least one circuit adapted to detect use of the insulin delivery device.

Abstract: A method for preparing a geothermal system involves preparing a wellbore that extends into an underground magma reservoir. Characteristics of the drilling process and the borehole are monitored to detect when the magma reservoir is reached, such that specially configured drilling operations can be performed to drill to a target depth within the magma reservoir.

Abstract: A portable and convertible cooking device comprises a grilling and smoking cabinet, a tether, and a leg assembly, where the cabinet is convertible from a grill to a smoker and back to a grill. The cabinet is moveable from a fixed horizontal position on the leg assembly, for operating the cooking device as a grill, to a fixed vertical position on the leg assembly, for operating the cooking device as a smoker where the tether holds the cabinet in the smoking position. As such, the portable and convertible outdoor cooking device converts from a grill to a smoker quickly and easily. The leg assembly comprises a pair of U-shaped stands which are pivotally connected at respective hinges, such that the leg assembly is collapsible. The portable and convertible cooking device has a pair of wheels for easy transport of the cooking device while in the collapsed position.

Abstract: Example embodiments of the present disclosure provide an optical module sensor. An example optical module sensor may include an optical radiation-emitting device, a reference, an optical radiation receiver positioned, an electromagnetic interference shield, and a housing cap. The housing cap may include a barrier wall positioned such that the housing cap defines a transmission cavity and a receiving cavity. The optical radiation-emitting device and the reference sensor may be positioned within the transmission cavity and the optical radiation receiver may be positioned within the receiving cavity. The housing cap may include an attenuation wall positioned between the reference sensor and the optical radiation receiver.

Abstract: The present invention generally relates to systems, methods and program products for use with Exchange-Traded Funds (“ETF”) holding one or more secured notes backed by one or more precious metals.

Abstract: Provided is an optical element for a lithographic apparatus. The optical element includes a capping layer that includes oxygen vacancies therein. The oxygen vacancies prevent attack of the capping layer by preventing hydrogen and other species from penetrating the capping layer and underlying layers. The capping layer provides a low hydrogen recombination rate enabling hydrogen to clean the surface of the optical element. The capping layer may include an alloyed metal, a mixed metal oxide or a doped metal oxide and it may be a ruthenium capping layer that includes one or more dopants therein.

Abstract: The present disclosure relates to a vaccine comprising an amphiphile having the formula S-[B]-[U]-H and at least one peptide antigen conjugate having the formula selected from [S]-[E1]-A-[E2]-[U]-H and H-[U]-[E1]-A-[E2]-[S], wherein the amphiphile and/or the at least one peptide antigen conjugate comprises a dendron amplifier. The vaccine is useful in treating or preventing a cancer, an autoimmune disease, an allergy, an infectious disease, a cardiovascular disease, or a neurodegenerative disease.

Abstract: Fall detection and reporting technology, in which output from at least one sensor configured to sense, in a room of a building, activity associated with a patient falling is monitored and a determination is made to capture one or more images of the room based on the monitoring. An image of the room is captured with a camera positioned to include the patient within a field of view of the camera and the captured image of the room is analyzed to detect a state of the patient at a time of capturing the image. A potential fall event for the patient is determined based on the detected state of the patient and a message indicating the potential fall event for the patient is sent based on the determination of the potential fall event for the patient. Techniques are also described for fall detection and reporting using an on-body sensing device.

Abstract: An apparatus for sampling landfill gas from a landfill flowing through a pipe. The apparatus may comprise: an enclosure configured to receive a section of the pipe; a gas sampling port in the section of the pipe; at least one sensor device disposed in a region of the enclosure, the at least one sensor being coupled to the section of the pipe through the gas sampling port; and thermal insulation positioned to retain heat from the section of the pipe in the region of the enclosure. A method of operating a landfill gas recovery system. The method may comprise: flowing gas from a well riser pipe through a sampling subsystem to a collection system; and heating a portion of the sampling subsystem with the gas flowing from the well riser pipe to the collection system.

Abstract: A method of forming a composite part from a mufti-ply prepreg composite charge comprises reducing pressure inside a bladder, located in a chamber that is at atmospheric pressure, below the atmospheric pressure. The method also comprises placing the multi-ply prepreg composite charge, having a first shape, in the chamber and reducing pressure inside the chamber below the atmospheric pressure. The method additionally comprises, while maintaining pressure inside the chamber below the atmospheric pressure, expanding the bladder within the chamber by increasing pressure inside the bladder to the atmospheric pressure, so that the multi-ply prepreg composite charge is compressed between the bladder and a forming tool, which is located inside the chamber, and the multi-ply prepreg composite charge is configured by the forming tool to a second shape, different from the first shape. The method also comprises curing the multi-ply prepreg composite charge, having the second shape.

Abstract: Techniques are provided for controlling extraction of landfill gas from a landfill. The techniques include receiving user input indicating an upper methane concentration threshold and a lower methane concentration threshold, and obtaining a measurement of the concentration of methane in the sample of landfill gas. At least one processor may be used to determine whether to control an actuator to control the flow control mechanism to adjust the flow rate of the landfill gas being extracted from the landfill. The determining whether to adjust the flow rate may be performed by determining whether the measurement of the concentration of methane in the sample is greater than the upper methane concentration threshold and determining whether the measurement of the concentration of methane in the sample is less than the lower methane concentration threshold. The flow rate of landfill gas being extracted from the landfill may be adjusted based on the determining.

Abstract: Techniques are provided for controlling extraction of landfill gas from a landfill. The techniques include obtaining a measurement of concentrations of oxygen, carbon, and methane in a sample of landfill gas. At least one processor may be used to determine based on the measurement of the concentration of oxygen in the sample, the measurement of the concentration of methane in the sample, and the measurement of the concentration of carbon dioxide in the sample, a balance gas concentration in the sample. Further, the at least one processor may be used to determine whether the determined balance gas concentration in the sample is greater than a balance gas concentration threshold. Responsive to determining that the determined balance gas concentration in the sample is greater than the balance gas concentration threshold, an actuator controls the flow control mechanism to decrease the flow rate of the landfill gas being extracted from the landfill.

Abstract: Certain aspects of the present disclosure provide a relatively compact frequency-locked loop (FLL) using a discrete-time integrator. For certain aspects, the FLL also includes a supplemental oscillator and other circuitry that allows for saving the FLL frequency when a reference clock will be disconnected, maintaining a similar frequency during disconnection, and restoring the FLL frequency when the reference clock is reconnected. One example FLL circuit generally includes: an encoder; a combiner comprising a first input coupled to an output of the encoder; a digital-to-analog converter (DAC) comprising an input coupled to an output of the combiner; a discrete-time integrator comprising an input coupled to an output of the DAC; a voltage-controlled oscillator (VCO) comprising a control input coupled to an output of the discrete-time integrator; and a counter comprising an input coupled to an output of the VCO and comprising an output coupled to a second input of the combiner.

Abstract: Techniques for establishing a data connection are described. In an example, a computer system receives, from a second device of a computer network, first data associated with a first device and second data associated with the second device. The first device is not connected to the computer network. The computer system determines third data generated by one or more devices other than the first device and the second device and associated with at least one of: the first device, the second device, a user account, or the computer network. The computer system generates, based on the first data, the second data, and the third data, a confidence score indicating a likelihood of a user authorization to connect the first device to the computer network. The computer system sends, to the second device based on the confidence score, instructions associated with connecting the first device to the computer network.

Abstract: A method for unlocking and/or locking a privacy lockset from the exterior of the lockset or door and without the use of buttons, keys, or an object inserted into the lockset or door. The operator manipulates a magnetic object, such as a magnet or piece of ferrous metal, on the exterior of the door or lockset to cause an internal magnet attached to a rod to move the rod in and out of a collar, the far end of the rod in turn actuating the lock into a locked and/or unlocked position. Rotational, lateral, and/or thrust forces may be configured to actuate the lock. The invention may apply to rim locks, mortise locks, sliding door locks, cylinder locks, and non-keyed deadbolts.

Abstract: Described herein are devices and methods for generating new, lower-cost chloride solid electrolytes useful for lithium ion batteries. The devices replace higher cost, difficult to acquire elements such as Sc with less expensive, readily available elements such as Mg and Zr to form a highly conductive spinel structure. These materials may have a high ionic conductivity on the order of 0.23 mS/cm.

Abstract: Soles for articles of footwear including a mechanically anisotropic three-dimensional mesh. The mechanically anisotropic three-dimensional mesh can include one or more mechanically anisotropic regions with a first lattice shear modulus measured in a first direction and a second lattice shear modulus measured in a second direction opposite to or orthogonal to the first direction. The first and second lattice shear moduli are different to provide the three-dimensional mesh with mechanically anisotropic properties. The mechanically anisotropic three-dimensional mesh can be three-dimensionally printed.

Abstract: A delivery device for delivering a medical fluid to a patient has a housing configured for receiving a container at least partially filled with the medical fluid. The delivery device further has a drive mechanism associated with the housing configured for delivering the medical fluid from the container to the patient in a dosing procedure. The delivery device further has a module configured for detecting at least one of a property of the dosing procedure and a property of the medical fluid. The module has at least one dose detection sensor configured for detecting an initiation, progression, and completion of the dosing procedure based on a position of a stopper within the container. The module further has at least one temperature sensor configured for measuring a temperature of the medical fluid within the container based on a temperature of the container.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.