Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.

Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.

Abstract: The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.

Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.

Abstract: Aspects of the present disclosure describe systems and methods for generating and presenting providing one or more questions and/or prompts to a customers that enable the customer to identify, diagnose, and/or resolve any technical problems the customer may currently be facing. Administrators may provide input to an interface, such as a graphical user interface (“GUI”), to automatically develop, arrange, group, and/or generate the series of questions/prompts provided to the customer. Other interfaces may be generated to receive input corresponding to the questions from other users and react to the input received from such users with appropriate responses or further questions.

Abstract: The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a high-throughput manner.

Abstract: The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.

Abstract: This invention relates to novel compounds of formula (I). The compounds of the invention are hedgehog pathway antagonists. Specifically, the compounds of the invention are useful as Smoothened (SMO) inhibitors. The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of the Hedgehog pathway and SMO, for example cancer.

Abstract: This invention relates to novel compounds of formula (I). The compounds of the invention are hedgehog pathway antagonists. Specifically, the compounds of the invention are useful as Smoothened (SMO) inhibitors. The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of the Hedgehog pathway and SMO, for example cancer.

Abstract: Aspects of the present disclosure describe systems and methods for generating and presenting providing one or more questions and/or prompts to a customers that enable the customer to identify, diagnose, and/or resolve any technical problems the customer may currently be facing. Administrators may provide input to an interface, such as a graphical user interface (“GUI”), to automatically develop, arrange, group, and/or generate the series of questions/prompts provided to the customer. Other interfaces may be generated to receive input corresponding to the questions from other users and react to the input received from such users with appropriate responses or further questions.