Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. Said heterocyclic derivative compounds are complement factor D inhibitors. Such compounds are useful for treating complement related disorders including, but are not limited to, autoimmune, inflammatory, and neurodegenerative diseases.

Abstract: A mold for forming a flange of a wind turbine blade comprising a first flange portion including a plurality of lamina and having a generally planar shape and a second perpendicular flange including a plurality of lamina. A plurality of copper wires are disposed within the lamina for conducting heat delivered from a base portion through the first and second flange portions. The mold is free of fluid conduits with the flange portions moveable relative to the base portion.

Abstract: A mold for forming a wind turbine blade comprising first and second mold surfaces including a flange portion having an opening therein, wherein the first and second mold surfaces are configured for relative movement therebetween from an open position to a closed position. The opening of the first flange portion is aligned with the opening of the second flange portion when in the closed position, and a first magnet is disposed within the opening in the opening of the first mold surface, and a second magnet is disposed within the opening of the second mold surface.

Abstract: A method includes receiving via an audio playback device a first multicast transmission (e.g., an SSDP(HTTP)/Bonjour(DNS) presence announcement) from a computer hosting a digital media server. The first multicast transmission provides an indication of the presence of the digital media server (e.g., DLNA music server) on a network (e.g., a LAN). A request for a unicast connection is transmitted via the audio playback device to the digital media server, and, in the absence of a response to the request for a unicast connection, a second multicast transmission is transmitted via the audio playback device. The second multicast transmission includes information that allows the digital media server to establish a connection with the audio playback device to facilitate transmission of a unicast request for content.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subjuect compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds which are complement factor D inhibitors. Such compounds are useful for treating complement related disorders including, but are not limited to, autoimmune, inflammatory, and neurodegenerative diseases.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: An apparatus and method for operating a staking assembly includes a housing defining a machining passage having a longitudinal axis, an actuator rod disposed for axial movement along the longitudinal axis in the machining passage, having a first end configured to connect to a linear-reciprocating source of movement and a second end having a tool configured to deform a boss, and an air source configured to selectively provide a source of heated air.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: An electronic click wrench comprises a handle for applying torque through a shaft to a working head. The shaft includes torque sensing means for calculating the torque applied to a workpiece by the working head, and a trigger mechanism for sending a haptic feedback to a user by triggering a small movement of the handle relative to the working head when a set point torque is reached. The trigger mechanism comprises a permanent magnet that is normally anchored by magnetic attraction to a pole piece so as to resist separation when a force is applied through the handle, and an electromagnetic means actuable to reduce or cancel that magnetic attraction so as to permit separation of the pole piece and permanent magnet, thus generating the haptic feedback. Operation of the electromagnet may oppose the flux of the permanent magnet through the pole piece. Alternatively operation of the electromagnet may divert the flux of the permanent magnet away from the pole piece.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

Abstract: An electronic click wrench comprises a handle for applying torque through a shaft to a working head. The shaft includes torque sensing means for calculating the torque applied to a workpiece by the working head, and a trigger mechanism for sending a haptic feedback to a user by triggering a small movement of the handle relative to the working head when a set point torque is reached. The trigger mechanism comprises a permanent magnet that is normally anchored by magnetic attraction to a pole piece so as to resist separation when a force is applied through the handle, and an electromagnetic means actuable to reduce or cancel that magnetic attraction so as to permit separation of the pole piece and permanent magnet, thus generating the haptic feedback. Operation of the electromagnet may oppose the flux of the permanent magnet through the pole piece. Alternatively operation of the electromagnet may divert the flux of the permanent magnet away from the pole piece.