Abstract: Aspects and implementations of the present disclosure address shortcomings of existing technology by enabling autonomous vehicle simulations based on retro-reflection optical data. The subject matter of this specification can be implemented in, among other things, a method that involves initiating a simulation of an environment of an autonomous driving vehicle, the simulation including a plurality of simulated objects, each having an identification of a material type of the respective object. The method can further involve accessing simulated reflection data based on the plurality of simulated objects and retro-reflectivity data for the material types of the simulated objects, and determining, using an autonomous vehicle control system for the autonomous vehicle, a driving path relative to the simulated objects, the driving path based on the simulated reflection data.

Abstract: Systems, devices and methods to measure a haze value of a lens using a light proof box housing a stand, a light source and a camera. The stand has an orientation to position the lens to be flat, adjacent to the light source, and have the lens edge facing the light source. The light source is configured to emit a blue light into a lens edge of the lens. The camera is oriented to face a top surface of the lens, the camera is configured to measure blue light emitted from the top surface of the lens. A computing device coupled with the camera is configured to calculate the haze value of the lens based on the measured blue light.

Abstract: A lubricator assembly for servicing a tubular member includes a mounting base, a lubricant housing movably coupled to the mounting base and configured to receive lubricant from a lubricant source, a guide pin slidably disposed in the lubricant housing, a first seal positioned between the guide pin and the lubricant housing and a second seal positioned between the guide pin and the lubricant housing, and a first chamber extending between the first seal and the second seal, wherein the guide pin is configured to direct lubricant disposed in the first chamber against the tubular member in response to the tubular member engaging the guide pin.

Abstract: Large format polymeric containers formed by injection molding include a main body having internal surfaces of high density and smoothness that define the internal space. The large format containers can include external features such as reinforcement ribs that are formed integrally with the container body, the reinforcement ribs having greater thicknesses than other portions of the walls of the container. The internal surfaces can include rounded corners and sloping towards a center of the container. Methods of manufacturing the large format polymeric containers include forming the polymeric main body using injection molding. The polymeric main body can be formed of multiple injection molded parts that are joined, or formed as a single piece. The injection molding can include applying between approximately 700 bar and approximately 1100 bar of pressure where at least a portion of the internal surface contacts a mold surface.

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

Abstract: A lubricator assembly for servicing a tubular member includes a mounting base, a lubricant housing movably coupled to the mounting base and configured to receive lubricant from a lubricant source, a guide pin slidably disposed in the lubricant housing, a first seal positioned between the guide pin and the lubricant housing and a second seal positioned between the guide pin and the lubricant housing, and a first chamber extending between the first seal and the second seal, wherein the guide pin is configured to direct lubricant disposed in the first chamber against the tubular member in response to the tubular member engaging the guide pin.

Abstract: The present invention provides a method for treating a cancer, comprising (a) identifying a patient with acquired resistance to an EGFR kinase inhibitor; and (b) administering to the patient an anti-cancer agent, and treating the patient with radiation therapy.

Abstract: A method of forming a halftone screen, the method comprising: representing a first tone range by forming a plurality of dots arranged in a grid; representing a second tone range by forming a plurality of substantially cross-shaped dots arranged in a grid, the cross-shaped dots contained within respective dot cells and having four arms, a distal end of at least one of the arms wider than a proximal end, the second tone range darker than the first tone range; and representing a third tone range by forming a plurality of substantially cross-shaped dots arranged in a grid, the cross-shaped dots contained within respective dot cells and having four arms, a proximal end of at least one of the arms wider than the proximal end of at least one arm of the cross-shaped dots representing the second tone range, the third tone range darker than the second tone range.

Abstract: A method of forming a halftone screen comprising representing each of a first, second, third and fourth tone range of increasing darkness by forming a plurality of dots arranged in a grid; the dots representing the second tone range larger than the dots representing the first tone range; the dots representing the third tone range having a body section and at least one extension extending toward a or respective nearest neighbor(s), the extension(s) narrower in width than the body section, the dots representing the third tone range substantially the same size as the dots representing the second tone range; and the dots representing the fourth tone range having a body section and at least one extension extending toward a or respective nearest neighbor(s), the extension(s) greater in width than the extension(s) associated with the dots representing the third tone range. A halftone screen and a printing system are also disclosed.

Abstract: A method of forming a halftone screen, the method comprising: representing a first tone range by forming a plurality of dots arranged in a grid; representing a second tone range by forming a plurality of substantially cross-shaped dots arranged in a grid, the cross-shaped dots contained within respective dot cells and having four arms, a distal end of at least one of the arms wider than a proximal end, the second tone range darker than the first tone range; and representing a third tone range by forming a plurality of substantially cross-shaped dots arranged in a grid, the cross-shaped dots contained within respective dot cells and having four arms, a proximal end of at least one of the arms wider than the proximal end of at least one arm of the cross-shaped dots representing the second tone range, the third tone range darker than the second tone range.

Abstract: The present invention provides a method for treating a cancer, comprising (a) identifying a patient with acquired resistance to an EGFR kinase inhibitor; and (b) administering to the patient an anti-cancer agent, and treating the patient with radiation therapy.

Abstract: A method of forming a halftone screen comprising representing each of a first, second, third and fourth tone range of increasing darkness by forming a plurality of dots arranged in a grid; the dots representing the second tone range larger than the dots representing the first tone range; the dots representing the third tone range having a body section and at least one extension extending toward a or respective nearest neighbour(s), the extension(s) narrower in width than the body section, the dots representing the third tone range substantially the same size as the dots representing the second tone range; and the dots representing the fourth tone range having a body section and at least one extension extending toward a or respective nearest neighbour(s), the extension(s) greater in width than the extension(s) associated with the dots representing the third tone range. A halftone screen and a printing system are also disclosed.

Abstract: A method and apparatus for facilitating the termination of cables to equipment mounted inside equipment racks or cabinets comprising of one or more cable termination equipment such as patch panels, cable termination strips and terminal blocks, and printed circuit boards fitted with cable termination blocks or fibre optic termination equipment. The method and apparatus of this invention make it possible to terminate cables to rack mounted equipment with ease and comfort.

Abstract: The invention provides a prodrug platform technology for improving the therapeutic value of a variety of parent drug compounds by altering and improving drug characteristics such as aqueous solubility, hydrolytic stability, therapeutic index, toxicity profile, pharmacolcinetics and selectivity while allowing the potential for synthetic elaboration. The prodrug platform is particularly well suited for targeting therapeutic drugs, including anti-tumor drugs and antibiotics, to specific receptors on target cells (e.g., cancer cells and bacteria). The platform is a technology for providing an improved, preactivated form of a therapeutic drug, and for optionally targeting such drug to target cells or biological molecules. The invention is broadly applicable to many different therapeutic drugs, as well as to a variety of diseases and conditions, including a variety of forms of cancer and bacterial infections.

Abstract: Nucleic acids encoding human IL-13, and purified IL-13 proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.