Patents by Inventor Andrew Michael Leach
Andrew Michael Leach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10934519Abstract: The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.Type: GrantFiled: July 29, 2011Date of Patent: March 2, 2021Assignee: Global Life Sciences Solutions USA LLCInventors: Jaydeep Roy, Andrew Michael Leach, Weston Blaine Griffin, Stefan Rakuff, Philip Alexander Shoemaker
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Patent number: 10591557Abstract: Provided is an apparatus and method comprising, an airlock chamber; a cryogenic chamber; an equilibrator positioned between the airlock chamber and the cryogenic chamber that is configured to allow for the passage of a sample along to the cryogenic chamber; and a cooling unit that is thermally coupled to the equilibrator. Collectively, the airlock chamber, equilibrator, and the cryogenic chamber define a travel path. A machine-readable medium, comprising instructions which when executed by a controller causes a sample to be cooled, is also provided.Type: GrantFiled: October 29, 2012Date of Patent: March 17, 2020Assignee: General Electric CompanyInventors: Andrew Michael Leach, James Richard Trigger, John Arthur Urbahn
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Patent number: 10184711Abstract: A cryogen cooling system to cool a superconducting magnet is disclosed herein utilizing embedded vertical tubing with a large heat exchanging surface area. The tubing encompasses the magnet which is further surrounded by a 4 Kelvin thermal shield for extended ride-through. In one embodiment, the system is a hyperpolarizer having an internal high-pressure gas storage for quench gas and to initiate cool-down. Aspects of the invention utilize a minimal volume of pressurized gas, for example, four (4) liters of pressurized gaseous helium in a 150 mL liquid helium system. As such, the prior vent stack has been removed, along with the helium vessel and quench paths/ducts. The method of using the system is further simplified during ramping while the cool-down process utilizing liquids supplied from external dewars has been eliminated. Significant advantages include reducing the helium volume (and cost associated therewith) and allowing for a hermetically sealed vacuum system that is leak-proof.Type: GrantFiled: May 19, 2014Date of Patent: January 22, 2019Assignee: GENERAL ELECTRIC COMPANYInventors: Ernst Wolfgang Stautner, Andrew Michael Leach
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Patent number: 9829474Abstract: The present invention is directed to methods of acetate quantification and acetate complexes useful in the methods of acetate quantification. Such methods and complexes are useful for any application where acetate quantification is desired, including measuring of concentration of 13C hyperpolarized acetate for imaging agent quality control in MRI and NMR spectroscopy. The disclosed acetate complexes may be prepared from acetate, Fe3+, and sulfosalicylic acid and from acetate, Fe3+, and salicylic acid.Type: GrantFiled: October 16, 2015Date of Patent: November 28, 2017Assignee: General Electric CompanyInventors: Rui Chen, Andrew Michael Leach, Manuel Alfred Palacios
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Publication number: 20170108481Abstract: The present invention is directed to methods of acetate quantification and acetate complexes useful in the methods of acetate quantification. Such methods and complexes are useful for any application where acetate quantification is desired, including measuring of concentration of 13C hyperpolarized acetate for imaging agent quality control in MRI and NMR spectroscopy. The disclosed acetate complexes may be prepared from acetate, Fe3+, and sulfosalicylic acid and from acetate, Fe3+, and salicylic acid.Type: ApplicationFiled: October 16, 2015Publication date: April 20, 2017Applicant: GENERAL ELECTRIC COMPANYInventors: Rui CHEN, Andrew Michael LEACH, Manuel Alfred PALACIOS
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Patent number: 9227173Abstract: A method for dynamic filtration of a pharmaceutical product is provided. The method includes using an unconditioned resin configured to selectively retain one or more components from a mixture having the pharmaceutical product and where the unconditioned resin is configured to be activated by a medium of the mixture. The method further includes the use of at least one positioning material disposed adjacent to the unconditioned resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position.Type: GrantFiled: November 9, 2011Date of Patent: January 5, 2016Assignee: General Electric CompanyInventors: Andrew Michael Leach, Peter Miller, Eric John Telfeyan, David Brandon Whitt
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Publication number: 20150332829Abstract: A cryogen cooling system to cool a superconducting magnet is disclosed herein utilizing embedded vertical tubing with a large heat exchanging surface area. The tubing encompasses the magnet which is further surrounded by a 4 Kelvin thermal shield for extended ride-through. In one embodiment, the system is a hyperpolarizer having an internal high-pressure gas storage for quench gas and to initiate cool-down. Aspects of the invention utilize a minimal volume of pressurized gas, for example, four (4) liters of pressurized gaseous helium in a 150 mL liquid helium system. As such, the prior vent stack has been removed, along with the helium vessel and quench paths/ducts. The method of using the system is further simplified during ramping while the cool-down process utilizing liquids supplied from external dewars has been eliminated. Significant advantages include reducing the helium volume (and cost associated therewith) and allowing for a hermetically sealed vacuum system that is leak-proof.Type: ApplicationFiled: May 19, 2014Publication date: November 19, 2015Applicant: GENERAL ELECTRIC COMPANYInventors: Ernst Wolfgang Stautner, Andrew Michael Leach
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Publication number: 20150168079Abstract: A thermal switching device is presented. The thermal switching device includes a plurality of serpentine capillaries having a first end and a second end, where the first end is configured to be operatively coupled to a heating unit and the second end is configured to be operatively coupled to a cooling unit, and where the plurality of serpentine capillaries is configured to transfer heat from the heating unit to the cooling unit by circulating a working fluid in the plurality of serpentine capillaries.Type: ApplicationFiled: December 17, 2013Publication date: June 18, 2015Applicant: General Electric CompanyInventors: Ernst Wolfgang Stautner, Andrew Michael Leach
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Patent number: 8763410Abstract: Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.Type: GrantFiled: April 21, 2008Date of Patent: July 1, 2014Assignee: General Electric CompanyInventors: David Brandon Whitt, Andrew Michael Leach, Peter Miller, Eric Telfeyan
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Patent number: 8731640Abstract: A fluid path system includes a vial containing a pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.Type: GrantFiled: January 13, 2012Date of Patent: May 20, 2014Assignee: General Electric CompanyInventors: John Arthur Urbahn, Jan Henrik Ardenkjaer-Larsen, Andrew Michael Leach, Eric John Telfeyan, David Key Dietrich, David Brandon Whitt, Peter Miller, Ernst Wolfgang Stautner
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Publication number: 20130029411Abstract: The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.Type: ApplicationFiled: July 29, 2011Publication date: January 31, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Jaydeep Roy, Andrew Michael Leach, Weston Blaine Griffin, Stefan Rakuff, Philip Alexander Shoemaker
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Patent number: 8318099Abstract: Embodiments of the invention include a wireless sensor, such as an RFID tag, that includes a substrate, an antenna disposed on the substrate, and an environmentally sensitive sensor material disposed over at least a portion of said substrate. Other embodiments an RFID tag and at least one antibody coupled to the RFID tag. The RFID tag includes a substrate, circuitry disposed on the substrate, and an antenna coupled to the substrate. The at least one antibody is capable of affecting the signals emanating from the RFID tag. Further embodiments include a detection system that includes a reader. Yet other embodiments include a method for detecting specific analytes. The method includes providing an RFID tag which emanates a first signal having a first frequency, and enabling the REID tag to emanate a second signal having a second frequency upon attraction of a specific analyte to the RFID tag.Type: GrantFiled: October 26, 2005Date of Patent: November 27, 2012Assignee: General Electric CompanyInventors: Radislav Alexandrovich Potyrailo, William Guy Morris, Kenneth Brakeley Welles, II, Andrew Michael Leach, Andrew David Pris
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Patent number: 8226907Abstract: A microfluidic channel is provided. The microfluidic channel includes a first substrate having at least one microfluidic channel pattern. Further, the microfluidic channel includes a porous material disposed on the first substrate and occupying the at least one microfluidic channel pattern.Type: GrantFiled: May 25, 2006Date of Patent: July 24, 2012Assignee: General Electric CompanyInventors: Andrew Michael Leach, Thomas Paul Dunton, Christopher David Goewey, Radislav Alexandrovich Potyrailo, Caibin Xiao, Prashant Vishwanath Shrikhande
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Publication number: 20120117985Abstract: A fluid path system includes a vial containing a pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.Type: ApplicationFiled: January 13, 2012Publication date: May 17, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: John Arthur Urbahn, Jan Henrik Ardenkjaer-Larsen, Andrew Michael Leach, Eric John Telfeyan, David Key Dietrich, David Brandon Whitt, Peter Miller, Ernst Wolfgang Stautner
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Patent number: 8147758Abstract: A sensor including a substrate and a sensing element disposed on a substrate is provided. The sensing element includes a sensing matrix in contact with a flow of water, an indicator for one or more chemical species in the flow of water, and a selectivity component that reacts reversibly with the one or more chemical species. The sensor also includes a light source configured to direct light through the substrate and the sensing element. The sensor further includes a light detector configured to receive transmitted light from the substrate and the sensing matrix and to generate a signal representative of selective wavelengths of the light indicative of the one or more chemical species in the flow of water.Type: GrantFiled: June 23, 2006Date of Patent: April 3, 2012Assignee: General Electric CompanyInventor: Andrew Michael Leach
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Publication number: 20120053364Abstract: A method for dynamic filtration of a pharmaceutical product is provided. The method includes using an unconditioned resin configured to selectively retain one or more components from a mixture having the pharmaceutical product and where the unconditioned resin is configured to be activated by a medium of the mixture. The method further includes the use of at least one positioning material disposed adjacent to the unconditioned resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position.Type: ApplicationFiled: November 9, 2011Publication date: March 1, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Andrew Michael Leach, Peter Miller, Eric John Telfeyan, David Brandon Whitt
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Publication number: 20110180482Abstract: A device for dynamic filtration of a pharmaceutical product is provided. The device includes a resin configured to selectively retain one or more components from a mixture having the pharmaceutical product, where the resin is configured to be activated by a medium of the mixture. The device further includes at least one positioning material disposed adjacent to the resin, where the positioning material is configured to provide mechanical support to the resin to at least partially retain the resin in position. In certain embodiments, the device does not require conditioning immediately prior to filtration.Type: ApplicationFiled: April 7, 2011Publication date: July 28, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Andrew Michael Leach, Peter Miller, Eric Telfeyan, David Brandon Whitt
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Patent number: 7977660Abstract: An article includes a substrate assembly for use in a detector system. The substrate assembly includes a substrate; a sample reception structure secured to the substrate; a test window extending through the substrate; and a fluid channel defined by a surface of the substrate and extending from the sample reception structure to the test window.Type: GrantFiled: March 10, 2008Date of Patent: July 12, 2011Assignee: General Electric CompanyInventors: Radislav Alexandrovich Potyrailo, Scott Martell Boyette, Glenn Alfred Johnson, William Guy Morris, Ronald James Wroczynski, Andrew Michael Leach, Peter Miller, Caibin Xiao
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Publication number: 20100251732Abstract: Provided is an apparatus and method for introducing a sample into a cryogenic system comprising, an airlock chamber, a sample path having a first end connected to the airlock chamber and a second end connected to a cryogenic helium bath, an equilibrator, inserted into the sample path and positioned between the airlock and the cryogenic bath and which allows for passage of a sample to the cryogenic helium bath, and a cooling unit to coupled to the equilibration to control the temperature of the equilibrator. A machine-readable medium, comprising instructions which when executed by a controller causes a sample to be positioned within the cryogenic system, is also provided.Type: ApplicationFiled: April 6, 2009Publication date: October 7, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Andrew Michael Leach, James Richard Trigger, John Arthur Urbahn
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Publication number: 20100194574Abstract: A method for detecting an aerosol plume includes emitting a light beam from a light source, the light beam having at least one light pulse, wherein the light pulse having a pulse width of between about 10 picoseconds (ps) and about 75 nanoseconds (ns), detecting backscattered light produced by the at least one light pulse interacting with particles in the aerosol plume, determining a presence of the aerosol plume based on the detected backscattered light, and outputting a signal indicating the presence of the aerosol plume.Type: ApplicationFiled: January 30, 2009Publication date: August 5, 2010Inventors: David James Monk, Michael Joseph O'Brien, Andrew Michael Leach, Juntao Wu, Rui Chen, Boon Kwee Lee, Sergei Dolinsky, Weizhong Yan, Jan Abraham Braam, Jeffery Glenn Van Keuren