Abstract: A multipoint lock including a pivoting lock bolt including a fixed pivot point and a sliding pivot point, a translating lock bolt, a linkage coupled to and configured to pivot the pivoting lock bolt and to translate the translating lock bolt, an actuation mechanism configured to actuate the linkage and to effect pivoting of the pivoting lock bolt and translation of the translating lock bolt, and an input mechanism configured to receive user input and transmit the user input to the actuation mechanism, the user unput including shifting the input mechanism between an unlocked position and a locked position.

Abstract: Devices, systems, and methods related to a fenestration unit are described herein. The fenestration unit may include a horizontal member and a vertical member that intersect at a corner. The fenestration unit may include an end cap coupled within an access opening including a housing including a horizontal housing portion and vertical housing portion, the horizontal housing portion coupled to a seal and the vertical housing portion defining a cover operable to cover the access opening. The fenestration unit may include a corner block operable to couple the horizontal member and the vertical member including a body including a top portion, a first side portion, a second side portion, and a bottom portion, the body defining a plurality of cavities, the plurality of cavities each operable to receive a fastener therethrough.

Abstract: Devices, systems, and methods related to a fenestration unit are described herein. The fenestration unit may include a frame including a plurality of frame members, wherein the plurality of frame members includes an upper rail member, a lower rail member, a first stile member, a second stile member, the lower rail member including two parallel metallic extrusions a space defined therebetween and a thermal break coupled to the lower rail member and located within the space. The thermal break may include a solid body of thermally insulating material defining a first side portion, a second side portion, and an intermediate portion between the first side portion and the second side portion, the solid body of thermally insulating material being asymmetrical about an X-Y plane.

Abstract: A multipoint lock including a pivoting lock bolt including a fixed pivot point and a sliding pivot point, a translating lock bolt, a linkage coupled to and configured to pivot the pivoting lock bolt and to translate the translating lock bolt, an actuation mechanism configured to actuate the linkage and to effect pivoting of the pivoting lock bolt and translation of the translating lock bolt, and an input mechanism configured to receive user input and transmit the user input to the actuation mechanism, the user unput including shifting the input mechanism between an unlocked position and a locked position.

Abstract: Various aspects of the disclosure relate to modular sill systems for sliding panel doors and windows, collectively “sliding fenestration units.” In various examples, modular sill systems include multiple separate and distinct base components that provide tracks on which one or more panels are able to slide.

Abstract: Apparatus (1) for manufacturing a three-dimensional object from a powder, the apparatus comprising: a work surface (170); a build bed (201) having a build area (190), the build area (190) being comprised within the work surface (170), wherein successive layers of said three-dimensional object are formed in the build bed (201); a first powder supply module (2) fixedly arranged on a first side of the work surface (170), outward from a first side of the build bed (201); a second powder supply module (3) fixedly arranged on a second side of the work surface (170), outward from a second side of the build bed (201); a first powder distribution sled (300) operable to distribute powder dosed to the work surface (170) from the first powder supply module (2) while moving in a first direction from the first side of the work surface (170) towards the second side of the work surface (170), and from the second powder supply module (3) while moving in a second direction from the second side of the work surface (170) towards

Abstract: A method for the manufacture of three-dimensional objects is disclosed, utilising an independently operable printing sled (350) for sintering fusible powder and an independently operable powder distribution sled (300) for depositing a layer of fusible powder on the sintered layer. Since the printing sled and the powder distribution sled are independently operable, the time between sintering and deposition can be altered, dependent on the printing conditions and materials, resulting in an enhanced bond between the layers of the three-dimensional object.

Abstract: Various aspects of the disclosure relate to modular sill systems for sliding panel doors and windows, collectively “sliding fenestration units.” In various examples, modular sill systems include multiple separate and distinct base components that provide tracks on which one or more panels are able to slide.

Abstract: According to some embodiments, a multi-panel door system includes a fixed panel and an active panel. Both panels are secured to the astragal of the door frame by securement members driven into and through hinges connected to the active panel, through the astragal, and into the fixed panel. The securement members are driven through a middle portion of the astragal stem in order to align the fixed and active panels in a recessed position with respect to the door frame. The fixed panel and the active panel are coplanar. Hinge support plates are placed between the hinges and the astragal and communicate forces transmitted through the securement members into deeper portions of the astragal.

Abstract: According to some embodiments, a multi-panel door system includes a fixed panel and an active panel. Both panels are secured to the astragal of the door frame by securement members driven into and through hinges connected to the active panel, through the astragal, and into the fixed panel. The securement members are driven through a middle portion of the astragal stem in order to align the fixed and active panels in a recessed position with respect to the door frame. The fixed panel and the active panel are coplanar. Hinge support plates are placed between the hinges and the astragal and communicate forces transmitted through the securement members into deeper portions of the astragal.

Abstract: According to some embodiments, a multi-panel door system includes a fixed panel and an active panel. Both panels are secured to the astragal of the door frame by securement members driven into and through hinges connected to the active panel, through the astragal, and into the fixed panel. The securement members are driven through a middle portion of the astragal stem in order to align the fixed and active panels in a recessed position with respect to the door frame. The fixed panel and the active panel are coplanar. Hinge support plates are placed between the hinges and the astragal and communicate forces transmitted through the securement members into deeper portions of the astragal.

Abstract: According to some embodiments, a multi-panel door system includes a fixed panel and an active panel. Both panels are secured to the astragal of the door frame by securement members driven into and through hinges connected to the active panel, through the astragal, and into the fixed panel. The securement members are driven through a middle portion of the astragal stem in order to align the fixed and active panels in a recessed position with respect to the door frame. The fixed panel and the active panel are coplanar. Hinge support plates are placed between the hinges and the astragal and communicate forces transmitted through the securement members into deeper portions of the astragal.

Abstract: The instant disclosure describes compositions and methods for treating diseases and conditions of the central and peripheral nervous system. The disclosure includes compositions and methods based on use of a 4-acylaminopyridine derivative in combination with one or more other neurogenic agents. One 4-acylaminopyridine derivative is MKC-231.

Abstract: The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of a GABA agent or GABA analog, in combination with one or more other neurogenic agents, to stimulate or activate the formation of new nerve cells.

Abstract: The disclosure provides compositions and methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure provides compositions and methods based on the use of D-cycloserine in combination with the neurogenic agent, which synergistically stimulates or activates the formation of new nerve cells.

Abstract: The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use nootropic agents, optionally in combination with one or more other neurogenic agents, to stimulate or activate the formation of new nerve cells.

Abstract: The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system including by stimulating or increasing neurogenesis, neuroproliferation, and/or neurodifferentiation. The disclosure includes compositions and methods based on use of a peroxisome proliferator-activated receptor (PPAR) agent, optionally in combination with one or more neurogenic agents, to stimulate or increase a neurogenic response and/or to treat a nervous system disease or disorder.

Abstract: The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on muscarinic receptor modulation, such as via inhibition of acetylcholine esterase (AChE) activity, alone or in combination with another neurogenic agent to stimulate or activate the formation of new nerve cells.

Abstract: The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of a 5HTR agent, optionally in combination with one or more other neurogenic agents, to stimulate or activate the formation of new nerve cells.