Abstract: According to various aspects of this disclosure, the present disclosure relates to a fusion protein comprising a truncated complement receptor 1 (CR1) protein or a functional fragment thereof. In some aspects, the fusion protein further comprises a complement receptor 2 (CR2) protein or a functional fragment thereof. Certain aspects of this disclosure relate to an adeno-associated virus (AAV) vector comprising a polynucleotide comprising a promoter operably linked to a nucleic acid encoding a CR2-CRI fusion protein. Other aspects of this disclosure relate to a method of treating a subject suffering from a complement-mediated disorder, the method comprising administering any of the fusion proteins disclosed herein or any of the AAV vectors disclosed herein.

Abstract: The present disclosure relates to molecules capable of binding to both CD20 and PD1, as well as pharmaceutical compositions comprising such molecules and methods of use thereof.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: Provided herein are compositions and methods for retargeting viral particles. e.g. adeno-associated virus (AAV) particles, to muscle cells using muscle-specific surface proteins. AAV adapted accordingly may be a viable gene therapy platform for the treatment of a skeletal muscle related disorder (e.g., X-linked myotubular myopathy (XLMTM). Duchenne muscular dystrophy (DMD), myotonic dystrophy (DM1), Facioscapulohumeral muscular dystrophy Type 1 (FSHD), congenital muscular dystrophy type 1A (MDC1A), Limb girdle muscular dystrophy, dystroglycanopathy, etc.) in a patient in need thereof.

Abstract: This invention relates to a computer implemented method and a computer program product for simulating a 3D object in a browser and sharing that simulation with a plurality of other users on other client devices. There is provided an in-browser simulator comprising: a rendering engine: a physics engine; and an application programming interface (API) mapping the functions of the physics engine to the rendering engine. The API is configured to establish a communication link with the other client devices and to share the simulation data with those devices over the established communication link. In one embodiment, multiple client devices can share their simulations contemporaneously and simulations on one client device can interact with simulations on other devices.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: A respirator has a shell that defines a breathable air zone for a user wearing the respirator. An air flow control system for the respirator has an air delivery conduit within the shell of the respirator, a valve member moveable relative to the air delivery conduit and within the shell to vary the amount of air flow through the air delivery conduit, and a valve actuator outside of the shell of the respirator. The valve actuator is manipulatable by a user of the respirator while wearing the respirator to control movement of the valve member.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).

Abstract: The invention relates generally to genetically modified non-human animals expressing human polypeptides and their methods of use.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: A method of controlling a blower system of a powered air purifying respirator to deliver a substantially uniform volumetric airflow to a user, the system including a fan powered by a variable speed electric motor, the motor controlled by an electronic control unit for delivering a forced flow of air through at least one filter to a user. There is also provided an air purifying respirator blower system using such a method.

Abstract: According to certain embodiments, the present disclosure provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds a target antigen and a second antigen binding domain that binds a complement component. In certain embodiments, the bispecific antigen-binding molecules of the present disclosure are capable of binding to the target antigen with an EC50 of about 10 nM or less, and/or are capable of promoting complement deposition on the target antigen with an EC50 of about 10 nM. In certain embodiments, the bispecific antigen-binding molecules of the disclosure are useful for treating diseases in which inhibition or reduction of the growth of an infectious agent or cancer cell is desired and/or therapeutically beneficial.

Abstract: There is provided a method of controlling a powered air purifying respirator blower system to deliver a substantially uniform volumetric airflow to a user, the system comprising a fan powered by a battery in communication with a variable speed electric motor, the variable speed electric motor is controlled by an electronic control unit for delivering a forced flow of air through at least one filter to a user, comprising the steps of: (a) determining an estimated system run time by summing a battery run time remaining and a system run time; and (b) altering a speed of the variable speed electric motor when the estimated system run time is equal to or less than a desired system run time.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: This invention relates to a computer implemented method and a computer program product for providing a virtual robotics programming competition. The method comprising the steps of on a server, providing access for a remote client device to a physics library, a physics engine, a rendering engine and an application programming interface (API) mapping the functions of the physics engine to the rendering engine; setting a programming challenge for a user operating the remote client device; receiving a simulation computer program code for a virtual robot from the remote client device; miming the simulation computer program code in a challenge environment; and grading the performance of the simulation computer program code. The performance of the simulation computer program code can be judged based on the results of a live multiplayer robot battle. In this way, students may compete against each other in robotics competitions without the expense and other pitfalls of having to travel to remote locations.

Abstract: An automatic, autonomous, and aircraft-centric interference advisory method is executed entirely on a fist aircraft operating on a movement area of a runway, the movement are including ramps, taxiways, and runways. The method includes a processor onboard the first aircraft computing a first movement projection for the first aircraft using first aircraft data received at the first aircraft; the processor computing additional second movement projections for multiple second aircraft operating on the movement area of the airport using second data regarding each of the multiple second aircraft; the processor detecting a threat to the first aircraft on approach to a defined intersection of the movement area from any of the multiple second aircraft based on a corresponding second movement projection within a configurable time limit of entry into the defined intersection by the first aircraft; and providing on the first aircraft, a threat advisory for a detected threat.

Abstract: This invention relates to a computer implemented method and a computer program product for simulating a 3D object in a browser and sharing that simulation with a plurality of other users on other client devices. There is provided an in-browser simulator comprising: a rendering engine; a physics engine; and an application programming interface (API) mapping the functions of the physics engine to the rendering engine. The API is configured to establish a communication link with the other client devices and to share the simulation data with those devices over the established communication link. In one embodiment, multiple client devices can share their simulations contemporaneously and simulations on one client device can interact with simulations on other devices.

Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that bind specifically to a coronavirus spike protein and methods of using such antibodies and fragments for treating or preventing viral infections (e.g., coronavirus infections).